scholarly journals The role of point‐of‐care tests in antibiotic stewardship for urinary tract infections in a resource‐limited setting on the Thailand–Myanmar border

2015 ◽  
Vol 20 (10) ◽  
pp. 1281-1289 ◽  
Author(s):  
Lauren Chalmers ◽  
Jessica Cross ◽  
Cindy S. Chu ◽  
Aung Pyae Phyo ◽  
Margreet Trip ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Antibiotic Stewardship ◽  
Point Of Care ◽  
Resource Limited Setting ◽  
Resource Limited ◽  
Tract Infections ◽  
Point Of Care Tests ◽  
Limited Setting

A multifaceted intervention to reduce rates of catheter-associated urinary tract infections in a resource-limited setting

2014 ◽  
Vol 42 (1) ◽  
pp. 12-16 ◽  
Author(s):  
L. Gayani Tillekeratne ◽  
Darren R. Linkin ◽  
Mariah Obino ◽  
Afua Omar ◽  
Mary Wanjiku ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Multifaceted Intervention ◽  
Resource Limited Setting ◽  
Resource Limited ◽  
Tract Infections ◽  
Limited Setting

scholarly journals Sensitivity of C-Reactive Protein and Procalcitonin Measured by Point-of-Care Tests to Diagnose Urinary Tract Infections in Nursing Home Residents: A Cross-Sectional Study

2020 ◽  
Author(s):  
S D Kuil ◽  
S Hidad ◽  
J C Fischer ◽  
J Harting ◽  
C M P M Hertogh ◽  
...  
Keyword(s):  
Nursing Home ◽  
Urinary Tract ◽  
Sample Size ◽  
Urinary Tract Infections ◽  
Point Of Care ◽  
Nursing Home Residents ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Tract Infections ◽  
Point Of Care Tests

Abstract Background Diagnosing urinary tract infections (UTIs) in nursing home residents is complex, as specific urinary symptoms are often absent and asymptomatic bacteriuria (ASB) is prevalent. The aim of this study was to assess the sensitivity of blood C-reactive protein (CRP) and procalcitonin (PCT), measured by point-of-care tests (PoCTs), to diagnose UTIs in this setting. Methods Elderly residents (≥65 years old) with a suspected UTI were recruited from psychogeriatric, somatic, or rehabilitation wards across 13 participating nursing homes. CRP and PCT were tested simultaneously in the same study participants. To assess the tests’ sensitivities, a stringent definition of “true” UTI was used that included the presence of symptoms, urinary leucocytes, a positive urine culture, and symptom resolution during antibiotic treatment covering isolated uropathogen(s). The original sample size was 440 suspected UTI episodes, in order to detect a clinically relevant sensitivity of at least 65% when calculated using the matched analysis approach to compare both PoCTs. Results After enrollment of 302 episodes (68.6% of the planned sample size), an unplanned and funder-mandated interim analysis was done, resulting in premature discontinuation of the study for futility. For 247 of 266 eligible episodes, all mandatory items required for the true UTI definition (92.9%) were available. In total, 49 episodes fulfilled our stringent UTI definition (19.8%). The sensitivities of CRP (cut-off, 6.5 mg/L) and PCT (cut-off, 0.025 ng/mL) were 52.3% (95% confidence interval [CI], 36.7–67.5%) and 37.0% (95% CI, 23.2–52.5%), respectively. Conclusions Our results indicate that CRP and PCT are not suitable tests for distinguishing UTI and ASB in nursing home residents. Clinical Trials Registration Netherlands Trial Registry NL6293.

scholarly journals Point-of-care tests for urinary tract infections: protocol for a systematic review and meta-analysis of diagnostic test accuracy

BMJ Open ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. e033424
Author(s):  
David Fraile Navarro ◽  
Frank Sullivan ◽  
Amaya Azcoaga-Lorenzo ◽  
Virginia Hernandez Santiago
Keyword(s):  
Systematic Review ◽  
Urinary Tract ◽  
Diagnostic Accuracy ◽  
Urinary Tract Infections ◽  
Point Of Care ◽  
Meta Analysis ◽  
Data Availability ◽  
Antibiotic Prescribing ◽  
Tract Infections ◽  
Point Of Care Tests

IntroductionUrinary tract infections (UTIs) are the second most common type of infection worldwide, accounting for a large number of primary care consultations and antibiotic prescribing. Current diagnosis is based on an empirical approach, relying on symptoms and occasional use of urine dipsticks. The diagnostic reference standard is still urine culture, although it is not routinely recommended for uncomplicated UTIs in the community, due to time to diagnosis (48 hours). Faster point-of-care tests have been developed, but their diagnostic accuracy has not been compared. Our objective is to systematically review and meta-analyse the diagnostic accuracy of currently available point-of-care tests for UTIs.Methods and analysisStudies evaluating the diagnostic accuracy of point-of-care tests for UTIs will be included. PubMed, Web of Science, Embase and Cochrane Database of Systematic Reviews were searched from inception to 1 June 2019. Data extraction and risk-of-bias assessment will be assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. Meta-analysis will be performed depending on data availability and heterogeneity.Ethics and disseminationThis is a systematic review protocol and therefore formal ethical approval is not required, as no primary, identifiable, personal data will be collected. Patients or the public were not involved in the design of our research. However, the findings from this review will be shared with key stakeholders, including patient groups, clinicians and guideline developers, and will also be presented and national and international conferences.PROSPERO registration numberCRD42018112019.

scholarly journals The Role of Gut, Vaginal, and Urinary Microbiome in Urinary Tract Infections: From Bench to Bedside

Diagnostics ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 7
Author(s):  
Tomislav Meštrović ◽  
Mario Matijašić ◽  
Mihaela Perić ◽  
Hana Čipčić Paljetak ◽  
Anja Barešić ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Subsequent Development ◽  
Potential Influence ◽  
Urinary Microbiome ◽  
Important Field ◽  
Tract Infections ◽  
The Relationship ◽  
Current Paradigm

The current paradigm of urinary tract infection (UTI) pathogenesis takes into account the contamination of the periurethral space by specific uropathogens residing in the gut, which is followed by urethral colonization and pathogen ascension to the urinary bladder. Consequently, studying the relationship between gut microbiota and the subsequent development of bacteriuria and UTI represents an important field of research. However, the well-established diagnostic and therapeutic paradigm for urinary tract infections (UTIs) has come into question with the discovery of a multifaceted, symbiotic microbiome in the healthy urogenital tract. More specifically, emerging data suggest that vaginal dysbiosis may result in Escherichia coli colonization and prompt recurrent UTIs, while urinary microbiome perturbations may precede the development of UTIs and other pathologic conditions of the urinary system. The question is whether these findings can be exploited for risk reduction and treatment purposes. This review aimed to appraise the three aforementioned specific microbiomes regarding their potential influence on UTI development by focusing on the recent studies in the field and assessing the potential linkages between these different niches, as well as evaluating the state of translational research for novel therapeutic and preventative approaches.

439 THE ROLE OF THE URINE PRODUCTION IN RECURENT URINARY TRACT INFECTIONS IN WOMEN

2009 ◽  
Vol 8 (4) ◽  
pp. 230
Author(s):  
E.P. Van Haarst ◽  
E.B. Cornel ◽  
B.L. Ronkes ◽  
E.A. Heldeweg
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Urine Production ◽  
Tract Infections
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