scholarly journals Multicenter study to evaluate a new enumeration method for hematopoietic stem cell collection management

Transfusion ◽  
2017 ◽  
Vol 57 (8) ◽  
pp. 1949-1955 ◽  
Author(s):  
Monique Grommé ◽  
Henk Russcher ◽  
Eric Braakman ◽  
J. Henriëtte Klinkspoor ◽  
Johan A. Dobber ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Multicenter Study ◽  
Collection Management ◽  
Hematopoietic Stem ◽  
Stem Cell Collection

Vascular access for optimal hematopoietic stem cell collection

2020 ◽  
Author(s):  
Chloé Couzin ◽  
Sandra Manceau ◽  
Jean‐Sébastien Diana ◽  
Laure Joseph ◽  
Alessandra Magnani ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Vascular Access ◽  
Hematopoietic Stem ◽  
Stem Cell Collection

The impact of diabetes mellitus and other comorbidities on hematopoietic stem cell collection and hematologic recovery post-transplantation

2016 ◽  
Vol 58 (1) ◽  
pp. 241-243
Author(s):  
Mark A. Fiala ◽  
Michael Slade ◽  
Stephanie Wang ◽  
Soo Park ◽  
John DiPersio ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Post Transplantation ◽  
Hematopoietic Stem ◽  
The Impact ◽  
Stem Cell Collection

scholarly journals Impact of Oral Side Effects from Conditioning Therapy Before Hematopoietic Stem Cell Transplantation: Protocol for a Multicenter Study (Preprint)

2017 ◽  
Author(s):  
Michael T Brennan ◽  
Bengt Hasséus ◽  
Allan J Hovan ◽  
Judith E Raber-Durlacher ◽  
Nicole MA Blijlevens ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Radiation Therapy ◽  
Stem Cell ◽  
Side Effects ◽  
Hematopoietic Stem Cell ◽  
Multicenter Study ◽  
Burden Of Illness ◽  
Hematopoietic Stem ◽  
Oral Complications

BACKGROUND The oral cavity is a common site of complications related to the cytotoxic effect of high-dose chemotherapy and radiation therapy. Considering our limited understanding of the burden of illness in the oral cavity from various cytotoxic therapies, it is difficult to produce evidence-based, preventive and management protocols. A prospective multicenter study is necessary to collect data on the burden of illness from various cytotoxic regimens. OBJECTIVE The objectives of this prospective international observational multicenter study in hematopoietic stem cell transplant (HSCT) patients are to establish the nature, incidence and temporal relationship of oral complications related to conditioning regimens (chemotherapy with or without total body irradiation), stem cell transplantation and the immunologic reactions (mainly graft-vs-host-disease) that may follow, and to determine what subjective and objective oral complications related to treatment can predict negative clinical and economic outcomes and reduced quality of life. METHODS Adult patients at six study sites receiving full intensity conditioning, reduced intensity conditioning or nonmyeloablative conditioning, followed by autologous or allogeneic hematopoietic stem cell infusion, are included. A pre-treatment assessment includes medical conditions, planned chemo- and radiation therapy regimen, medications, allergies, social history, patient report of oral problems, dental history, subjective oral complaints, objective measures of oral conditions, current laboratory values, dental treatment recommended and untreated dental disease. Starting 1-3 days after hematopoietic stem cell infusion, a bedside assessment is completed 3 days per week until resolution of neutropenia. A patient questionnaire is also completed during hospitalization. Beyond this time, patients with continued oral mucositis or other oral problems are followed 1 day per week in an inpatient or outpatient setting. Additional visits for urgent care for acute oral problems after hospitalization are documented. Autologous transplant patients are being followed up at 100 days (SD 30 days) and at 1 year (SD 30 days) post-transplantation to identify any long-term side effects. Patients treated with allogeneic transplantation are being followed at 100 days (SD 30 days), 6 months (SD 30 days), and 12 months (SD 30 days). The follow-up assessments include cancer response to therapy, current medical conditions, medications, subjective and objective oral findings, quality of life measures and laboratory values. The targeted enrollment is 254 patients who have received HSCT. RESULTS A total of 260 participants have been enrolled, with 233 (91%) who have received HSCT. We anticipate enrollment of 20-30 additional participants to obtain the sample size of 254 enrolled participants who have received HSCT. CONCLUSIONS The results of the ongoing prospective study will provide a unique dataset to understand the impact of oral complications on patients undergoing HSCT and provide needed evidence for guidelines regarding the management of this patient cohort.

Successful hematopoietic stem cell collection in patients who fail initial plerixafor mobilization for autologous stem cell transplant

2014 ◽  
Vol 29 (6) ◽  
pp. 293-298 ◽  
Author(s):  
Muthu Veeraputhiran ◽  
Tania Jain ◽  
Simon Cronin ◽  
Zaid Al-Kadhimi ◽  
Muneer H. Abidi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Stem Cell Transplant ◽  
Autologous Stem Cell Transplant ◽  
Cell Transplant ◽  
Hematopoietic Stem ◽  
Stem Cell Collection

scholarly journals Factors influencing platelet clumping during peripheral blood hematopoietic stem cell collection

Transfusion ◽  
2017 ◽  
Vol 57 (5) ◽  
pp. 1142-1151
Author(s):  
Gagan Mathur ◽  
Sarah L. Mott ◽  
Laura Collins ◽  
Gail A. Nelson ◽  
C. Michael Knudson ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Peripheral Blood ◽  
Hematopoietic Stem ◽  
Factors Influencing ◽  
Stem Cell Collection
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