scholarly journals Total platelet donation count and donation frequency are determinants of plateletpheresis‐associated lymphopenia

Transfusion ◽  
2021 ◽  
Author(s):  
Linda Thuer ◽  
Andreas Brosig ◽  
James A. Hutchinson ◽  
Viola Hähnel ◽  
Robert Offner ◽  
...  
Keyword(s):  
Donation Frequency

P4-346: Beta-amyloid peptide in the plasma of individuals undergoing plasmapheresis: Effect of age and donation frequency

2013 ◽  
Vol 9 ◽  
pp. P858-P859
Author(s):  
Montserrat Costa ◽  
Ana Maria Ortiz ◽  
Marylin Rosa-Bray ◽  
Juan Ignacio Jorquera
Keyword(s):  
Beta Amyloid ◽  
Amyloid Peptide ◽  
Beta Amyloid Peptide ◽  
Donation Frequency ◽  
Effect Of Age

Racial Differences in Motivators and Barriers to Blood Donation Among Blood Donors

2009 ◽  
Vol 133 (9) ◽  
pp. 1444-1447
Author(s):  
Beth H. Shaz ◽  
Derrick G. Demmons ◽  
Krista L. Hillyer ◽  
Robert E. Jones ◽  
Christopher D. Hillyer
Keyword(s):  
African American ◽  
African Americans ◽  
Racial Differences ◽  
Blood Donors ◽  
Blood Donation ◽  
Screening Process ◽  
Center Staff ◽  
Predominately White ◽  
Donation Frequency ◽  
The Right

Abstract Context.—Nationally, African Americans are underrepresented in community blood donation programs. To increase blood donation by African Americans, differences between motivators and barriers to blood donation between races should be investigated. Objective.—To investigate motivators and barriers to blood donation in African American and white blood donors. Design.—An 18-item, anonymous, self-administered questionnaire regarding demographics and motivators and barriers to donation was completed by blood donors at a predominately African American and a predominately white fixed donation site. Results.—A total of 599 participants (20% African American, 75% white, and 5% other) completed the survey. The most commonly reported reasons to donate included: “because it is the right thing to do” (45% African Americans and 62% white) and “because I want to help save a life” (63% African Americans and 47% white). Unpleasant experiences did not differ as a barrier to continue donation between African Americans and whites. African Americans placed more importance on donating blood to someone with sickle cell disease, convenience of blood donation, treatment of donor center staff, and level of privacy during the screening process. Conclusions.—These data suggest that in a large metropolitan area, reasons for donation among African American and white donors differ. To retain and increase donation frequency of African American donors, these factors should be considered in creating an African American donor recruitment and retention program.

The effect of blood donation frequency on iron status

2009 ◽  
Vol 41 (3) ◽  
pp. 165-169 ◽  
Author(s):  
A.S. Røsvik ◽  
R.J. Ulvik ◽  
T. Wentzel-Larsen ◽  
T. Hervig
Keyword(s):  
Blood Donation ◽  
Iron Status ◽  
Donation Frequency

Estimating the incidence of HIV infection in repeat blood donors with low average donation frequency

Transfusion ◽  
2020 ◽  
Author(s):  
Donald J. Brambilla ◽  
Michael P. Busch ◽  
Simone A. Glynn ◽  
Steven H. Kleinman ◽  
Keyword(s):  
Hiv Infection ◽  
Blood Donors ◽  
Donation Frequency

LONG TERM, FREQUENT PLASMA EXCHANGE DONATION OF CRYOPRECIPITATE

1987 ◽  
Author(s):  
B McLeod ◽  
R Sassetti ◽  
E Cole ◽  
P Scott
Keyword(s):  
Factor Viii ◽  
Plasma Exchange ◽  
Good Health ◽  
Complement C3 ◽  
Laboratory Monitoring ◽  
Extensive Experience ◽  
Normal Limits ◽  
Single Donor ◽  
Donation Frequency ◽  
Fresh Plasma

In plasma exchange donation (PED), several liters of fresh plasma are removed fran a donor with a pheresis instrument as a source of cryoprecipitate, and replaced with autologous cryoprecipitate-supernatant from the previous donation. Repetitive PED can produce large quantities of factor VIII from individual donors over time, with a favorable impact on donor exposure for factor VIII recipients. To clarify the implications for donor safety, we report our experience with several donors who have undergone multiple PEDs. Detailed observations are presented for one donor who has undergone PED 101 times between 5/83 and 1/87, and has provided all the factor VIII needed by his son (now age 14) with severe hemophilia A during this period. Exchange volume was gradually increased while donation frequency was gradually decreased. There were 23 exchanges of 2 L, 52 of 2.5 L, and 26 of 3 L for a total of 254 L plasma exchanged. Desmopressin (20 meg tV) was given before 45 more recent donations to augment factor VIII yield. A total of 343,274 IU factor VIII have been collected; the mean (±SD) yield from a 3 L, desmopressin- stimulated PED is 5598 ± 899 IU. The donor has remained in good health; he has noted no adverse effects fran any PED, and none have been found in laboratory monitoring. Prior to the 100th donation the following were within normal limits: CBC,platelet count, urinalysis, SMA-18, protein electrophoresis, IgG, IgA, IgM, hemolytic complement, C3, C4, fibronectin, prothrombin time, partial thromboplastin time, thranbin time, factor VIII:C (140%), factor VIII:Ag (134%), von Willebrand factor (86%) and fibrinogen (215 mg/dL). In another family, the father has donated 40 times since 1981 and the paternal grandmother has donated 31 times since 1984 with no untoward effects detected in clinical or laboratory monitoring. They have supported two moderately affected patients now ages 7 and 9. Extensive experience with these donors suggests that repeated PED is safe, and that a highly motivated donor can sometimes provide single donor support, even for a severe hemophiliac.

Evidence Of Relative Iron Deficiency in Apheresis Platelet Donors Correlates With Donation Frequency

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 1155-1155
Author(s):  
Frances Condon ◽  
Huihui Li ◽  
Debra Kessler ◽  
Vijay Nandi ◽  
Tomas Ganz ◽  
...  
Keyword(s):  
Platelet Count ◽  
Iron Deficiency ◽  
Board Of Directors ◽  
Serum Ferritin ◽  
Whole Blood ◽  
Advisory Committees ◽  
Donor Pool ◽  
Donation Frequency ◽  
Serum Hepcidin ◽  
Equity Ownership

Abstract A minimal hemoglobin (Hb) of 12.5 g/dL is required to protect blood donors from iron-deficiency and anemia and ensure collection of an adequate red cell product. The effects of whole blood or red blood cell (RBC) donation on donor Hb concentration and iron stores have been extensively studied. These changes have not been well characterized in platelet donors. Because platelet donation can occur as frequently as every 72 hours up to 24 times per year, tubes taken for donor testing (approximately 50 mL) at each donation may result in the loss of blood volume equivalent to 2-3 units of whole blood (500 mL each) in frequent donors. We hypothesized that iron deficiency and its associated thrombocytosis is underappreciated in platelet donors. To test this hypothesis, we proposed to 1) analyze the degree of iron deficiency / depletion in platelet donors, 2) assess the correlation between pre-donation platelet count with iron stores, and 3) evaluate the effect of platelet donation frequency on erythropoiesis- and iron-related parameters in white males age 40-65 years, typically representative of the platelet donor pool. Eligible donors were selected from a donor pool who had not donated whole blood / RBCs in the previous 12 months prior to study enrollment. Prospective participants with a history of iron-related pathology (e.g. iron deficiency, hereditary hemochromatosis, anemia, bleeding, or abnormal colonoscopy findings) were excluded from the study. Eligible donors who had not donated any blood products in the prior 12 months were enrolled as controls. Analysis of circulating RBC parameters, serum iron, serum ferritin, serum transferrin concentration and saturation, serum hepcidin, and soluble serum TfR1 were performed and correlations analyzed. The “TfR1 Ferritin Index” (i.e. log(sTfR1/ferritin)) was also evaluated, representing iron restricted erythropoiesis in the absence of frank iron deficiency. Statistical significance was measured using a student t-test; data is presented as mean ± s.e.m. and p<0.05 was considered statistically significant. Fifty eligible platelet donors and eight controls were enrolled in the study. Average age of platelet donors was 56±1 years, no different from that of controls (54±2 years; p=0.6). More donors (22/50 (44%)) were taking multivitamins compared to controls (2/8 (25%)). Only a small number of platelet donors (2/50 (4%)) had previously been deferred for low Hb. Although within the normal range, platelet donors were found to have a lower serum ferritin (54±6 vs.169±60 ng/mL; p<0.0001), transferrin saturation (30±1 vs. 40±7%; p=0.04), and serum hepcidin (35±3 vs. 57±11 mg/mL; p=0.006) relative to controls. In addition, TfR1 ferritin index was suggestive of relatively iron restricted erythropoiesis in platelet donors relative to controls (p=0.005). These results support our premise that platelet donors are relatively more iron deficient. Furthermore, among donors, lower MCV (89±1 vs. 93±1 fL; p=0.03) and CHr (31±0.4 vs. 32±0.4 pg; p=0.03) were observed in those who had donated platelets more than ten times relative to those who had donated once or twice. Lower hepcidin concentration (24±3 vs. 48±6 mg/mL, p=0.005), serum ferritin (38±7 vs. 77±16 ng/mL; p=0.04), and hepcidin/log ferritin (16.0±1.6 vs. 27.0±3.4, p=0.01) were observed in those who had donated platelets more than ten donations relative to those who had donated once or twice. Correlations between hepcidin and donation frequency (r=-0.396), serum ferritin and donation frequency (r=-0.323), and confirmatory hepcidin and log ferritin (r=0.454) were noted in platelet donors. Lastly, pre-donation platelet count correlated with sTfR1 (r=0.418), suggesting that thrombocytopoiesis is stimulated in the setting of relative iron restricted erythropoiesis. Taken together, this pilot study for the first time demonstrates evidence of iron restricted erythropoiesis in frequent apheresis platelet donors. An analysis of iron- and erythropoiesis-related parameters in a broader population of frequent platelet donors (i.e. male and female, white and non-white donors) may demonstrate a potential utility of iron replacement. Disclosures: Ganz: Intrinsic LifeSciences: Equity Ownership, Membership on an entity’s Board of Directors or advisory committees. Nemeth:Intrinsic LifeSciences: Equity Ownership, Membership on an entity’s Board of Directors or advisory committees. Westerman:Intrinsic LifeSciences: Employment, Equity Ownership, Membership on an entity’s Board of Directors or advisory committees.

scholarly journals FinDonor 10 000 study: A cohort to identify iron depletion and factors affecting it in Finnish blood donors

2018 ◽  
Author(s):  
Jukka Partanen ◽  
Pia Niittymäki ◽  
Nina Nikiforow ◽  
Elina Palokangas ◽  
Muriel Lobier ◽  
...  
Keyword(s):  
Whole Blood ◽  
Blood Donors ◽  
Iron Status ◽  
Time Lag ◽  
Time Of Day ◽  
Cool Temperature ◽  
Factors Affecting ◽  
Iron Stores ◽  
Increased Risk ◽  
Donation Frequency

AbstractBackground and ObjectivesThere is increasing evidence that frequent blood donation depletes the iron stores of some blood donors. The FinDonor 10 000 study was set up to study iron status and factors affecting iron stores in Finnish blood donors. In Finland, iron supplementation for at-risk groups has been in place since the 1980’s.Material and Methods2584 blood donors (N= 8003 samples) were recruited into the study alongside the standard donation at three donation sites in the capital region of Finland between 5/2015 and 12/2017. All participants were asked to fill out a questionnaire about their health and lifestyle. Blood samples were collected from the sample pouch of whole blood collection set, kept in cool temperature and processed centrally. Whole blood count, CRP, ferritin and sTFR were measured from the samples and DNA was isolated for GWAS studies.ResultsParticipant demographics, albeit in general similar to the general blood donor population in Finland, indicated some bias toward older and more frequent donors. Participation in the study increased median donation frequency of the donors. Analysis of the effect of time lag from the sampling to the analysis and the time of day when sample was drawn revealed small but significant time-dependent changes.ConclusionThe FinDonor cohort now provides us with tools to identify potential donor groups at increased risk of iron deficiency as factors explaining this risk. The increase in donation frequency during the study suggests that scientific projects can be used to increase the commitment of blood donors.

scholarly journals BLOOD DONATION;

2018 ◽  
Vol 24 (12) ◽  
pp. 1806-1811
Author(s):  
Nazish Saqlain ◽  
Nisar Ahmed ◽  
Aatika Ahmed ◽  
Sidra Hareem
Keyword(s):  
Blood Donation ◽  
Cross Sectional Study ◽  
Kappa Statistics ◽  
Single Session ◽  
Cross Sectional ◽  
Effective Interventions ◽  
Participation Of Women ◽  
Donation Process ◽  
Donation Frequency ◽  
Donated Blood

The participation of women in blood donation process has been scarce equallyin low & high resourced countries. Every year 3.5 million blood donations are collected inPakistan with very little percentage of females donating blood. Objective: The objective of thestudy was to assess the knowledge, attitude and beliefs of female attendants accompanyingthe patients. Study Design: Cross-sectional study. Setting: The Children’s Hospital & Instituteof Child Health, Lahore, regarding blood donation. Period: 1st June to 31st December, 2015.Material & Methods: 306 females of age 16-50 years accompanying a patient in the hospitalwere randomly selected. After taking informed consent, a self-designed questionnaire validatedby Kappa Statistics program was distributed to the participants. Data was analyzed by usingSPSS 22. Results: The mean age of female attendants was 29.57 years. 31.7% had neverreceived any education. Only 12.7% had donated blood before. 93.8% had the idea that ablood transfusion is a lifesaving procedure but only half of them knew the common bloodgroups. 87.3% knew that both males and females can donate blood but 75.5% thought thatmales are better donors than females. There was a lack of knowledge about certain importantfacts including transfusion transmissible infections, donation frequency, duration and volumeof blood collected during a single session. Majority females were of the view that they are toofragile to donate blood and severe and prolonged anemia can develop after donating blood.Conclusion: There is a need to develop effective interventions for the education & motivationof potential female donors towards blood donation in order to increase the donor turnover rate.

A Pilot Trial To Assess College Student’s Willingness To Donate Blood.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4029-4029 ◽  
Author(s):  
Derrick G. Demmons ◽  
Colleen P. Crittenden ◽  
Mark Lee ◽  
Beth H. Shaz ◽  
Miriam Burnett ◽  
...  
Keyword(s):  
College Students ◽  
African American ◽  
African Americans ◽  
Blood Donation ◽  
Pilot Trial ◽  
Recruitment Methods ◽  
School Work ◽  
Knowledge And Beliefs ◽  
Willingness To Donate ◽  
Donation Frequency

Abstract Background: Nationally, African Americans are significantly underrepresented in community blood donation programs. The need to understand the willingness to donate blood among African Americans is essential. In this study, we explore factors that serve as motivators and barriers to blood donation identified by college students at two Historical Black Colleges/Universities (HBCUs). Methods: HBCU students at least 18 years of age were given the opportunity to complete a paper-based or on-line 41-item questionnaire to assess the participant’s demographic background, donation frequency, motivators and barriers toward donation, knowledge and beliefs regarding blood donation, and specific behavioral practices. No personal identifiers were used. Univariate and bivariate analyses were conducted to describe the sample. Results: 409 individuals completed the survey. 95% self-identified as African-American and 45% of college students reported previously donating blood. Student’s felt that incentives, personal requests to donate from blood centers, blood drives sponsored by campus organizations, and the university involvement in promoting blood drives were significant motivating factors for donating blood (p<.05). Significant barriers against blood donation included believing donation was too painful, fear of feeling faint, dizzy, or nauseated, losing valuable time from school or work, too time consuming, and fear of deferral (p<.05). Conclusions: College students are willing to donate blood based on convenience, accessibility, and support from their university. Campus-based recruitment methods geared towards students, specifically those of African American descent, may prove beneficial for increasing the general pool of African American blood donors. Significant relationships between barriers, motivators, and donor status Χ2 Sig. *p<.05 Barriers against blood donation Too painful 60.20 .000 Would feel faint, dizzy, or nauseated 42.15 .000 Will lose valuable time from school/work 16.82 .002 Previously been told not to donate 8.49 .004 Takes too long 37.41 .000 Motivators toward blood donation Incentive for donating 14.56 .006 Personal request to donate from blood center 10.15 .038 Blood drive sponsored by campus organization 26.29 .000 University involvement in promoting blood drives 5.36 .021

scholarly journals Minority and foreign-born representation among US blood donors: demographics and donation frequency for 2006

Transfusion ◽  
2009 ◽  
Vol 49 (10) ◽  
pp. 2221-2228 ◽  
Author(s):  
Edward L. Murphy ◽  
Beth Shaz ◽  
Christopher D. Hillyer ◽  
Patricia Carey ◽  
Brian S. Custer ◽  
...  
Keyword(s):  
Blood Donors ◽  
Foreign Born ◽  
Donation Frequency
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