scholarly journals A systematic review and meta‐analyses of regional perfusion in donation after circulatory death solid organ transplantation

2021 ◽  
Author(s):  
Julie De Beule ◽  
Katrien Vandendriessche ◽  
Liset H. M. Pengel ◽  
Maria Irene Bellini ◽  
John H. Dark ◽  
...  

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
George Skowronski ◽  
Anil Ramnani ◽  
Dianne Walton-Sonda ◽  
Cynthia Forlini ◽  
Michael J. O’Leary ◽  
...  

Abstract Background Socio-cultural perceptions surrounding death have profoundly changed since the 1950s with development of modern intensive care and progress in solid organ transplantation. Despite broad support for organ transplantation, many fundamental concepts and practices including brain death, organ donation after circulatory death, and some antemortem interventions to prepare for transplantation continue to be challenged. Attitudes toward the ethical issues surrounding death and organ donation may influence support for and participation in organ donation but differences between and among diverse populations have not been studied. Objectives In order to clarify attitudes toward brain death, organ donation after circulatory death and antemortem interventions in the context of organ donation, we conducted a scoping review of international English-language quantitative surveys in various populations. Study appraisal A search of literature up to October 2020 was performed, using multiple databases. After screening, 45 studies were found to meet pre-specified inclusion criteria. Results 32 studies examined attitudes to brain death, predominantly in healthcare professionals. In most, around 75% of respondents accepted brain death as equivalent to death of the person. Less common perspectives included equating death with irreversible coma and willingness to undertake organ donation even if it caused death. 14 studies examined attitudes to organ donation following circulatory death. Around half of respondents in most studies accepted that death could be confidently diagnosed after only 5 min of cardiorespiratory arrest. The predominant reason was lack of confidence in doctors or diagnostic procedures. Only 6 studies examined attitudes towards antemortem interventions in prospective organ donors. Most respondents supported minimally invasive procedures and only where specific consent was obtained. Conclusions Our review suggests a considerable proportion of people, including healthcare professionals, have doubts about the medical and ethical validity of modern determinations of death. The prognosis of brain injury was a more common concern in the context of organ donation decision-making than certainty of death.



2021 ◽  
Vol 22 (3) ◽  
pp. e93-e104
Author(s):  
Rosario Mazzola ◽  
Francesco Cuccia ◽  
Alessandro Bertani ◽  
Slavisa Tubin ◽  
Pier Giulio Conaldi ◽  
...  


2011 ◽  
Vol 270 (1) ◽  
pp. 5-12 ◽  
Author(s):  
Juan Shan ◽  
Yinjia Guo ◽  
Lei Luo ◽  
Jun Lu ◽  
Chengwen Li ◽  
...  


2019 ◽  
Vol 75 (11) ◽  
pp. 1471-1480 ◽  
Author(s):  
Maryam Ghadimi ◽  
Zinat Mohammadpour ◽  
Simin Dashti-Khavidaki ◽  
Alireza Milajerdi


2019 ◽  
Vol 23 (6) ◽  
Author(s):  
Samantha J. Anthony ◽  
Hayley Stinson ◽  
Tanya Lazor ◽  
Katarina Young ◽  
Amos Hundert ◽  
...  


PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56974 ◽  
Author(s):  
Isabella Eckerle ◽  
Kerstin Daniela Rosenberger ◽  
Marcel Zwahlen ◽  
Thomas Junghanss


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