An intrinsic link to an extrinsic cause of cardiac xenograft growth after xenotransplantation

2022 ◽  
Author(s):  
Corbin E. Goerlich ◽  
Avneesh Singh ◽  
John A. Treffalls ◽  
Bartley Griffith ◽  
David Ayares ◽  
...  
Keyword(s):  
Xenograft Growth

scholarly journals TMOD-02. PEDIATRIC MEDULLOBLASTOMA XENOGRAFT GROWTH LOCATION TRANSFORMS TRANSCRIPTOMIC BUT NOT PHENOTYPIC PROFILES AND ALTERS SENSITIVITY TO RADIATION

2017 ◽  
Vol 19 (suppl_4) ◽  
pp. iv48-iv49
Author(s):  
Tina Etminan ◽  
Li Nan ◽  
Blake Moore ◽  
Brent Orr ◽  
Anita Hjelmeland ◽  
...  
Keyword(s):  
Xenograft Growth ◽  
Pediatric Medulloblastoma

scholarly journals Anthocyanin Induces Apoptosis of DU-145 CellsIn Vitroand Inhibits Xenograft Growth of Prostate Cancer

2015 ◽  
Vol 56 (1) ◽  
pp. 16 ◽  
Author(s):  
U-Syn Ha ◽  
Woong Jin Bae ◽  
Su Jin Kim ◽  
Byung Il Yoon ◽  
Sung Hoo Hong ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Xenograft Growth

scholarly journals CCR5 antagonism by maraviroc inhibits Hodgkin lymphoma microenvironment interactions and xenograft growth

Haematologica ◽  
2018 ◽  
Vol 104 (3) ◽  
pp. 564-575 ◽  
Author(s):  
Naike Casagrande ◽  
Cinzia Borghese ◽  
Lydia Visser ◽  
Maurizio Mongiat ◽  
Alfonso Colombatti ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Xenograft Growth

scholarly journals Effect of restin gene transfection on human gastric carcinoma xenograft growth in nude mice

2008 ◽  
Vol 16 (33) ◽  
pp. 3713
Author(s):  
Jian-Yong Zhang ◽  
Jin-Yi Li ◽  
Hong-Yu Li ◽  
Cong Dai ◽  
Chun-Lei Ma ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Nude Mice ◽  
Gene Transfection ◽  
Human Gastric Carcinoma ◽  
Xenograft Growth ◽  
Carcinoma Xenograft

scholarly journals Loss of LSR affects epithelial barrier integrity and tumor xenograft growth of CaCo-2 cells

Oncotarget ◽  
2016 ◽  
Vol 8 (23) ◽  
pp. 37009-37022 ◽  
Author(s):  
Bernd A. Czulkies ◽  
Justin Mastroianni ◽  
Lisa Lutz ◽  
Sarah Lang ◽  
Carsten Schwan ◽  
...  
Keyword(s):  
Tumor Xenograft ◽  
Epithelial Barrier ◽  
Barrier Integrity ◽  
Xenograft Growth ◽  
Tumor Xenograft Growth

scholarly journals Dual-mTOR Inhibitor Rapalink-1 Reduces Prostate Cancer Patient-Derived Xenograft Growth and Alters Tumor Heterogeneity

2020 ◽  
Vol 10 ◽  
Author(s):  
Federico La Manna ◽  
Marta De Menna ◽  
Nikhil Patel ◽  
Sofia Karkampouna ◽  
Maria De Filippo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patient ◽  
Tumor Heterogeneity ◽  
Mtor Inhibitor ◽  
Prostate Cancer Patient ◽  
Xenograft Growth ◽  
Patient Derived Xenograft

scholarly journals Circular RNA CDR1as Exerts Oncogenic Properties Partially through Regulating MicroRNA 641 in Cholangiocarcinoma

2020 ◽  
Vol 40 (15) ◽  
Author(s):  
Dingyang Li ◽  
Zhe Tang ◽  
Zhiqiang Gao ◽  
Pengcheng Shen ◽  
Zhaochen Liu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Target Genes ◽  
Circular Rna ◽  
Tumor Xenograft ◽  
Mrna Levels ◽  
Cell Behaviors ◽  
Xenograft Growth ◽  
Tumor Xenograft Growth

ABSTRACT It has been found that the circular RNA (circRNA) CDR1as is upregulated in cholangiocarcinoma (CCA) tissues. In this study, we tried to explore the roles of CDR1as in CCA. CDR1as was overexpressed or knocked down in human CCA cells to assess the effects of CDR1as on cell behaviors and tumor xenograft growth. In vitro, the CDR1as level was significantly increased in CCA cell lines. The results showed that CDR1as promoted the cell proliferation, migration, invasion, and activation of the AKT3/mTOR pathway in CCA cells. Moreover, miR-641, a predicted target microRNA (miRNA) of CDR1as, could partially reverse the effects of CDR1as on cell behaviors in CCA cells. Furthermore, CDR1as improved tumor xenograft growth, and it could be attenuated by miR-641 in vivo. Additionally, CDR1as expression was inversely correlated with miR-641 in CCA cells, and miR-641 could directly bind with CDR1as and its target genes, the AKT3 and mTOR genes. Mechanistically, CDR1as could bind with miR-641 and accelerate miR-641 degradation, which possibly leads to the upregulation of the relative mRNA levels of AKT3 and mTOR in RBE cells. In conclusion, our findings indicated that CDR1as might exert oncogenic properties, at least partially, by regulating miR-641 in CCA. CDR1as and miR-641 could be considered therapeutic targets for CCA.

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