scholarly journals Aerobic exercise training in the treatment of non-alcoholic fatty liver disease related fibrosis

2016 ◽  
Vol 594 (18) ◽  
pp. 5271-5284 ◽  
Author(s):  
Melissa A. Linden ◽  
Ryan D. Sheldon ◽  
Grace M. Meers ◽  
Laura C. Ortinau ◽  
E. Matthew Morris ◽  
...  
Keyword(s):  
Liver Disease ◽  
Exercise Training ◽  
Fatty Liver ◽  
Aerobic Exercise ◽  
Fatty Liver Disease ◽  
Aerobic Exercise Training ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Aerobic exercise training improves mitochondrial biogenesis and oxidative status in obese mice with nonalcoholic fatty liver disease: a non-randomized experimental study

2019 ◽  
Author(s):  
Matheus Santos de Sousa Fernandes ◽  
Lucas de Lucena Simões e Silva ◽  
Márcia Saldanha Kubrusly ◽  
Talitta Ricarlly Lopes de Arruda Lima ◽  
Cynthia Rodrigues Muller ◽  
...  
Keyword(s):  
Liver Disease ◽  
Exercise Training ◽  
Fatty Liver ◽  
Aerobic Exercise ◽  
Oxidative Metabolism ◽  
Fatty Liver Disease ◽  
Citrate Synthase ◽  
Maximum Velocity ◽  
Aerobic Exercise Training ◽  
Alcoholic Fatty Liver

Abstract Non-alcoholic fatty liver disease (NAFLD) is one of the most common forms of liver disease. Lifestyle modifications, such as a reduction in body weight (BW) and aerobic exercise training (AET), are effective treatments for NAFLD. The aim of the present study was to evaluate the effect of AET on hepatic oxidative metabolism in ob/ob mice. Male ob/ob mice were separated into two groups: the sedentary group (S), n=7, and the trained group (T), n=7. The T mice were submitted to an 8-week protocol of AET at 60% of the maximum velocity achieved in the running test. Before AET, no difference was observed in running capacity between the groups (S=10.4 ± 0.7 min vs. T= 13 ± 0.47 min). However, after AET, the running capacity was increased in the T group (12.8 ± 0.87 min) compared to the S group (7.2±0.63 min). Skeletal muscle in the T group (26.91±1.12 U/mg of protein) showed higher citrate synthase activity compared with the S group (19.28±0.88 U/mg of protein) (p =0.004) . BW and food consumption were significantly reduced in the T group compared to the S group (p=0.008 and p=0.001, respectively). The analysis of hepatic gene expression showed an increase in PGC-1a levels (p=0.002) and a reduction in CPT-1a levels (p=0.03). The levels of TBARs and carbonyls, as well as SOD, CAT and GST, were not different between the groups. In the nonenzymatic antioxidant system, we found that the T group had higher sulfhydryl (p = 0.02), GSH (p=0.001) and GSH/GSSG (p=0.02) activity. The activity of the metabolic enzymes citrate synthase (p=0.004) and β-HAD (p=0.01) was also increased in the T group. Besides improve in metabolism, no differences were observed in the histological analyses. In conclusion, our data demonstrate that AET improves BW control, mitochondrial functionality and oxidative metabolism in ob/ob mice.

scholarly journals Aerobic exercise training improves mitochondrial biogenesis and oxidative status in obese mice with nonalcoholic fatty liver disease: a non-randomized experimental study

2019 ◽  
Author(s):  
Matheus Santos de Sousa Fernandes ◽  
Lucas de Lucena Simões e Silva ◽  
Márcia Saldanha Kubrusly ◽  
Talitta Ricarlly Lopes de Arruda Lima ◽  
Cynthia Rodrigues Muller ◽  
...  
Keyword(s):  
Liver Disease ◽  
Exercise Training ◽  
Fatty Liver ◽  
Aerobic Exercise ◽  
Oxidative Metabolism ◽  
Fatty Liver Disease ◽  
Citrate Synthase ◽  
Maximum Velocity ◽  
Aerobic Exercise Training ◽  
Alcoholic Fatty Liver

Abstract Non-alcoholic fatty liver disease (NAFLD) is one of the most common forms of liver disease. Lifestyle modifications, such as a reduction in body weight (BW) and aerobic exercise training (AET), are effective treatments for NAFLD. The aim of the present study was to evaluate the effect of AET on hepatic oxidative metabolism in ob/ob mice. Male ob/ob mice were separated into two groups: the sedentary group (S), n=7, and the trained group (T), n=7. The T mice were submitted to an 8-week protocol of AET at 60% of the maximum velocity achieved in the running test. Before AET, no difference was observed in running capacity between the groups (S=10.4 ± 0.7 min vs. T= 13 ± 0.47 min). However, after AET, the running capacity was increased in the T group (12.8 ± 0.87 min) compared to the S group (7.2±0.63 min). Skeletal muscle in the T group (26.91±1.12 U/mg of protein) showed higher citrate synthase activity compared with the S group (19.28±0.88 U/mg of protein) (p =0.004) . BW and food consumption were significantly reduced in the T group compared to the S group (p=0.008 and p=0.001, respectively). The analysis of hepatic gene expression showed an increase in PGC-1a levels (p=0.002) and a reduction in CPT-1a levels (p=0.03). The levels of TBARs and carbonyls, as well as SOD, CAT and GST, were not different between the groups. In the nonenzymatic antioxidant system, we found that the T group had higher sulfhydryl (p = 0.02), GSH (p=0.001) and GSH/GSSG (p=0.02) activity. The activity of the metabolic enzymes citrate synthase (p=0.004) and β-HAD (p=0.01) was also increased in the T group. Besides improve in metabolism, no differences were observed in the histological analyses. In conclusion, our data demonstrate that AET improves BW control, mitochondrial functionality and oxidative metabolism in ob/ob mice.

scholarly journals Impact of exercise training on the sarcopenia criteria in non-alcoholic fatty liver disease: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Andrea Gonzalez ◽  
Mayalen Valero-Breton ◽  
Camila Huerta-Salgado ◽  
Oscar Achiardi ◽  
Felipe Simon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Resistance Training ◽  
Muscle Strength ◽  
Exercise Training ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Combined Training ◽  
Alcoholic Fatty Liver Disease

Sarcopenia is a highly prevalent complication of non-alcoholic fatty liver disease (NAFLD). We aimed to conduct a systematic review and meta-analyses to elucidate the exercise training (ET)'s efficacy on NAFLD adult patients' sarcopenia criteria. We identified relevant randomized controlled trials (RCT) in electronic databases PubMed, CINAHL, and Scopus. We selected seven RCT from 66 screened studies. The ET programs included endurance or combined (endurance and resistance) training. No study performed resistance training alone. The physical function improved with endurance or combined training (mean differences [MD] 8.26 mL/Kg*min [95% CI 5.27 to 11.24 mL/Kg*min], p < 0.0001); Muscle mass showed no evidence of the beneficial effects of endurance or combined training (MD 1.01 Kg [95% CI -1.78 to 3.80 Kg], p = 0.48). None of the selected studies evaluated muscle strength. Endurance and combined training increase physical function criteria but do not improve muscle mass criteria on sarcopenia in NAFLD patients. These results must be interpreted with caution for the small number of patients included in the RCTs analyzed, the different characteristics of the ET carried out, the non-use of resistance training, which prevents assess its effect on sarcopenia despite the evidence that recommends it and does not assessment muscle strength criteria in RCT include. Future research should include muscle strength assessments and resistance training to evaluate the effects in this condition. Exercise training is beneficial for sarcopenia in NAFLD but is necessary more experimental evidence to define the best type of training that positively affects the three criteria of sarcopenia. PROSPERO reference number CRD42020191471.

scholarly journals Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease

2016 ◽  
Vol 8 (27) ◽  
pp. 1137
Author(s):  
Ilaria Croci ◽  
Nuala M Byrne ◽  
Veronique S Chachay ◽  
Andrew P Hills ◽  
Andrew D Clouston ◽  
...  
Keyword(s):  
Liver Disease ◽  
Exercise Training ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Fat Oxidation ◽  
Alcoholic Fatty Liver ◽  
Diet And Exercise ◽  
Independent Effects ◽  
Alcoholic Fatty Liver Disease
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