scholarly journals Empowering human cardiac progenitor cells by P2Y14 nucleotide receptor overexpression

2017 ◽  
Vol 595 (23) ◽  
pp. 7135-7148
Author(s):  
Farid G. Khalafalla ◽  
Waqas Kayani ◽  
Arwa Kassab ◽  
Kelli Ilves ◽  
Megan M. Monsanto ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Cardiac Progenitor Cells ◽  
Nucleotide Receptor

P2Y 14 nucleotide receptor overexpression: Letting blind cardiac progenitor cells 'see' again

2017 ◽  
Vol 112 ◽  
pp. 139
Author(s):  
Farid Khalafalla ◽  
Waqas Kayani ◽  
Arwa Kassab ◽  
Kelli Ilves ◽  
Roberto Alvarez ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Cardiac Progenitor Cells ◽  
Nucleotide Receptor

Cardiac progenitor cells in terminally failing hearts: Immunohistological observations in human myocardium

2007 ◽  
Vol 55 (S 1) ◽  
Author(s):  
M Arnold ◽  
V Kufer ◽  
A Schütz ◽  
B Reiter ◽  
M Fittkau ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Human Myocardium ◽  
Cardiac Progenitor Cells

Breakthrough Regenerative Cardiopoietic Stem Cells and Related Technologies in the Field of Cardiovascular Medicine – From Bench to Bedside

2012 ◽  
Vol 7 (1) ◽  
pp. 14
Author(s):  
Christian Homsy ◽  
Keyword(s):  
Stem Cells ◽  
Cell Therapy ◽  
Progenitor Cells ◽  
Cardiac Disease ◽  
Cardiac Tissue ◽  
Cardiac Repair ◽  
Cardiac Diseases ◽  
Cardiac Progenitor Cells ◽  
Biotechnology Company ◽  
Cardiovascular Medicine

The scale of cardiac diseases, and in particular heart failure and acute myocardial infarction, emphasises the need for radically new approaches, such as cell therapy, to address the underlying cause of the disease, the loss of functional myocardium. Stem cell-based therapies, whether through transplanted cells or directing innate repair, may provide regenerative approaches to cardiac diseases by halting, or even reversing, the events responsible for progression of organ failure. Cardio3 BioSciences, a leading Belgian biotechnology company focused on the discovery and development of regenerative and protective therapies for the treatment of cardiac disease, was founded in this context in 2004. The company is developing a highly innovative cell therapy approach based on a platform designed to reprogramme the patient’s own stem cells into cardiac progenitor cells. The underlying rationale behind this approach is that, in order to reconstruct cardiac tissue, stem cells need to be specific to cardiac tissue. The key is therefore to provide cardiac-specific progenitor cells to the failing heart to induce cardiac repair.

scholarly journals Diabetes induces dysregulation of microRNAs associated with survival, proliferation and self-renewal in cardiac progenitor cells

Diabetologia ◽  
2021 ◽  
Author(s):  
Nima Purvis ◽  
Sweta Kumari ◽  
Dhananjie Chandrasekera ◽  
Jayanthi Bellae Papannarao ◽  
Sophie Gandhi ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Cardiac Progenitor Cells ◽  
Self Renewal

scholarly journals Novel Identified Circular Transcript of RCAN2, circ-RCAN2, Shows Deviated Expression Pattern in Pig Reperfused Infarcted Myocardium and Hypoxic Porcine Cardiac Progenitor Cells In Vitro

2021 ◽  
Vol 22 (3) ◽  
pp. 1390
Author(s):  
Julia Mester-Tonczar ◽  
Patrick Einzinger ◽  
Johannes Winkler ◽  
Nina Kastner ◽  
Andreas Spannbauer ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Progenitor Cells ◽  
Regulatory Networks ◽  
Circular Rnas ◽  
Cardiac Progenitor Cells ◽  
Tissue Samples ◽  
Healthy Myocardium ◽  
Acute Mi

Circular RNAs (circRNAs) are crucial in gene regulatory networks and disease development, yet circRNA expression in myocardial infarction (MI) is poorly understood. Here, we harvested myocardium samples from domestic pigs 3 days after closed-chest reperfused MI or sham surgery. Cardiac circRNAs were identified by RNA-sequencing of rRNA-depleted RNA from infarcted and healthy myocardium tissue samples. Bioinformatics analysis was performed using the CIRIfull and KNIFE algorithms, and circRNAs identified with both algorithms were subjected to differential expression (DE) analysis and validation by qPCR. Circ-RCAN2 and circ-C12orf29 expressions were significantly downregulated in infarcted tissue compared to healthy pig heart. Sanger sequencing was performed to identify the backsplice junctions of circular transcripts. Finally, we compared the expressions of circ-C12orf29 and circ-RCAN2 between porcine cardiac progenitor cells (pCPCs) that were incubated in a hypoxia chamber for different time periods versus normoxic pCPCs. Circ-C12orf29 did not show significant DE in vitro, whereas circ-RCAN2 exhibited significant ischemia-time-dependent upregulation in hypoxic pCPCs. Overall, our results revealed novel cardiac circRNAs with DE patterns in pCPCs, and in infarcted and healthy myocardium. Circ-RCAN2 exhibited differential regulation by myocardial infarction in vivo and by hypoxia in vitro. These results will improve our understanding of circRNA regulation during acute MI.

scholarly journals GW26-e2263 Protein Reprogramming Fibroblasts Into Cardiac Progenitor Cells for Cardiac Repair

2015 ◽  
Vol 66 (16) ◽  
pp. C10
Author(s):  
Xiaohong Li ◽  
Lin Jiang ◽  
Yongheng Fu ◽  
Mengzhen Zhang ◽  
Honghong Tan ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Cardiac Repair ◽  
Cardiac Progenitor Cells

Cardiac progenitor cells preferentially proliferate in areas of inflammatory injury

2009 ◽  
Vol 209 (3) ◽  
pp. S86
Author(s):  
David R. Stern ◽  
Ricardo Bello ◽  
David D'Alessandro ◽  
Jan Kajstura ◽  
Michael Zembala ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Cardiac Progenitor Cells ◽  
Inflammatory Injury

scholarly journals Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor Cells

2016 ◽  
Vol 291 (26) ◽  
pp. 13634-13648 ◽  
Author(s):  
Joshua K. Salabei ◽  
Pawel K. Lorkiewicz ◽  
Parul Mehra ◽  
Andrew A. Gibb ◽  
Petra Haberzettl ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glucose Metabolism ◽  
Progenitor Cells ◽  
Cardiac Progenitor Cells

scholarly journals Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells

2015 ◽  
Vol 290 (22) ◽  
pp. 13935-13947 ◽  
Author(s):  
Kaitlen Samse ◽  
Jacqueline Emathinger ◽  
Nirmala Hariharan ◽  
Pearl Quijada ◽  
Kelli Ilves ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Intracellular Localization ◽  
Cardiac Progenitor Cells ◽  
Functional Effect
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