scholarly journals Increased intestinal phosphate absorption, an often‐overlooked effect of vitamin D

2020 ◽  
Author(s):  
R. Todd Alexander
Keyword(s):  
Vitamin D ◽  
Phosphate Absorption ◽  
Intestinal Phosphate Absorption

Regulation by Vitamin D of Intestinal Phosphate Absorption

1980 ◽  
Vol 12 (05) ◽  
pp. 216-219 ◽  
Author(s):  
M. Peterlik ◽  
R. Wasserman
Keyword(s):  
Vitamin D ◽  
Phosphate Absorption ◽  
Intestinal Phosphate Absorption

scholarly journals Intestinal phosphate absorption and the effect of vitamin D: a comparison of rats with mice

2006 ◽  
Vol 91 (3) ◽  
pp. 531-537 ◽  
Author(s):  
Joanne Marks ◽  
Surjit K. Srai ◽  
Jürg Biber ◽  
Heini Murer ◽  
Robert J. Unwin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Phosphate Absorption ◽  
Intestinal Phosphate Absorption

scholarly journals Combination treatment with tenapanor and sevelamer synergistically reduces urinary phosphorus excretion in rats

2020 ◽  
Author(s):  
Andrew J. King ◽  
Jill Kohler ◽  
Cyra Fung ◽  
Zhengfeng Jiang ◽  
Allison Quach ◽  
...  
Keyword(s):  
Male Rats ◽  
Phosphate Binders ◽  
Phosphate Absorption ◽  
Phosphorus Excretion ◽  
Sevelamer Carbonate ◽  
Sodium Hydrogen Exchanger ◽  
Intestinal Phosphate Absorption ◽  
Urinary Phosphorus Excretion ◽  
Dose Levels ◽  
Nhe3 Inhibitor

The majority of patients with chronic kidney disease (CKD) receiving dialysis do not reach target serum phosphorus concentrations, despite treatment with phosphate binders. Tenapanor is a non-binder, sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor that reduces paracellular intestinal phosphate absorption. This pre-clinical study evaluated the effect of tenapanor and varying doses of sevelamer carbonate on urinary phosphorus excretion, a direct reflection of intestinal phosphate absorption. We measured 24-hour urinary phosphorus excretion in male rats assigned to groups dosed orally with vehicle or tenapanor (0.3 mg/kg/day) and provided a diet containing varying amounts of sevelamer (0-3% w/w). We also evaluated the effect of the addition of tenapanor or vehicle on 24-hour urinary phosphorus excretion to rats on a stable dose of sevelamer (1.5% w/w). When administered together, tenapanor and sevelamer decreased urinary phosphorus excretion significantly more than either tenapanor or sevelamer alone across all sevelamer dose levels. The Bliss statistical model of independence indicated that the combination was synergistic. A stable sevelamer dose (1.5% w/w) reduced mean (±standard error of the mean) urinary phosphorus excretion by 42±3% compared with vehicle; together, tenapanor and sevelamer reduced residual urinary phosphorus excretion by an additional 37±6% (P < 0.05). While both tenapanor and sevelamer reduce intestinal phosphate absorption individually, administration of tenapanor and sevelamer together results in more pronounced reductions in intestinal phosphate absorption than if either agent is administered alone. Further evaluation of combination tenapanor plus phosphate binder treatment in patients receiving dialysis with hyperphosphatemia is warranted.

Aluminum Hydroxide: Evaluation of Two Dosage forms and Two Dosing Schedules in Reducing Intestinal Phosphate Absorption

1978 ◽  
Vol 35 (1) ◽  
pp. 58-61
Author(s):  
Douglas R. Smith ◽  
Bruce S. Chang ◽  
Cary E. Johnson
Keyword(s):  
Aluminum Hydroxide ◽  
Dosage Forms ◽  
Phosphate Absorption ◽  
Intestinal Phosphate Absorption

scholarly journals Significant Species Differences in Intestinal Phosphate Absorption between Dogs, Rats, and Monkeys

2020 ◽  
Vol 66 (1) ◽  
pp. 60-67 ◽  
Author(s):  
Yasuhiro ICHIDA ◽  
Naoto HOSOKAWA ◽  
Ryushi TAKEMOTO ◽  
Takafumi KOIKE ◽  
Tasuku NAKATOGAWA ◽  
...  
Keyword(s):  
Species Differences ◽  
Phosphate Absorption ◽  
Intestinal Phosphate Absorption

L-thyroxine inhibits intestinal phosphate absorption in developing rabbits

1993 ◽  
Vol 13 (11) ◽  
pp. 1283-1293
Author(s):  
Stephen M. Borowitz ◽  
Garth S. Granrud
Keyword(s):  
Phosphate Absorption ◽  
Intestinal Phosphate Absorption

Absorption of Inorganic Phosphate in the Human Small Intestine

1979 ◽  
Vol 56 (5) ◽  
pp. 407-412 ◽  
Author(s):  
J. Walton ◽  
T. K. Gray
Keyword(s):  
Small Intestine ◽  
Inorganic Phosphate ◽  
Water Movement ◽  
Human Subjects ◽  
Sodium Concentration ◽  
Phosphate Concentration ◽  
Phosphate Absorption ◽  
Human Small Intestine ◽  
Intestinal Phosphate Absorption

1. Intestinal phosphate absorption in human subjects was studied by the technique of triple lumen intestinal perfusion in vivo. 2. Ileal phosphate absorption increased as the intraluminal phosphate concentration was increased. 3. Ileal rates of phosphate absorption were lower at any given intraluminal phosphate concentration than previously described jejunal rates. Acidification of the ileal lumen did not increase phosphate absorption. 4. Phosphate absorption was shown in the jejunum to be dependent on the intraluminal sodium concentration. 5. Phosphate absorption in the human small intestine consists of at least two components, one directly proportional to water movement and the second apparently independent of water movement.

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