Intrauterine growth restriction elevates circulating acylcarnitines and suppresses fatty‐acid metabolism genes in the fetal sheep heart

2021 ◽  
Author(s):  
Rachel R Drake ◽  
Samantha Louey ◽  
Kent L Thornburg
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Intrauterine Growth Restriction ◽  
Acid Metabolism ◽  
Growth Restriction ◽  
Fetal Sheep ◽  
Intrauterine Growth

scholarly journals Intrauterine growth restriction decreases NF-κB signaling in fetal pulmonary artery endothelial cells of fetal sheep

2018 ◽  
Vol 315 (3) ◽  
pp. L348-L359 ◽  
Author(s):  
R. Blair Dodson ◽  
Kyle N. Powers ◽  
Jason Gien ◽  
Paul J. Rozance ◽  
Gregory Seedorf ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Intrauterine Growth Restriction ◽  
Lung Diseases ◽  
Growth Restriction ◽  
Mouse Lung ◽  
Similar Degree ◽  
Fetal Sheep ◽  
Vascular Growth ◽  
Intrauterine Growth ◽  
Pulmonary Artery Endothelial Cell

Intrauterine growth restriction (IUGR) in premature newborns increases the risk for bronchopulmonary dysplasia, a chronic lung disease characterized by disrupted pulmonary angiogenesis and alveolarization. We previously showed that experimental IUGR impairs angiogenesis; however, mechanisms that impair pulmonary artery endothelial cell (PAEC) function are uncertain. The NF-κB pathway promotes vascular growth in the developing mouse lung, and we hypothesized that IUGR disrupts NF-κB-regulated proangiogenic targets in fetal PAEC. PAECs were isolated from the lungs of control fetal sheep and sheep with experimental IUGR from an established model of chronic placental insufficiency. Microarray analysis identified suppression of NF-κB signaling and significant alterations in extracellular matrix (ECM) pathways in IUGR PAEC, including decreases in collagen 4α1 and laminin α4, components of the basement membrane and putative NF-κB targets. In comparison with controls, immunostaining of active NF-κB complexes, NF-κB-DNA binding, baseline expression of NF-κB subunits p65 and p50, and LPS-mediated inducible activation of NF-κB signaling were decreased in IUGR PAEC. Although pharmacological NF-κB inhibition did not affect angiogenic function in IUGR PAEC, angiogenic function of control PAEC was reduced to a similar degree as that observed in IUGR PAEC. These data identify reductions in endothelial NF-κB signaling as central to the disrupted angiogenesis observed in IUGR, likely by impairing both intrinsic PAEC angiogenic function and NF-κB-mediated regulation of ECM components necessary for vascular development. These data further suggest that strategies that preserve endothelial NF-κB activation may be useful in lung diseases marked by disrupted angiogenesis such as IUGR.

scholarly journals Intrauterine Growth Restriction Is Associated with Changes in Polyunsaturated Fatty Acid Fetal-Maternal Relationships

2002 ◽  
Vol 52 (5) ◽  
pp. 750-755 ◽  
Author(s):  
Irene Cetin ◽  
Niccolò Giovannini ◽  
Gioia Alvino ◽  
Carlo Agostoni ◽  
Enrica Riva ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Intrauterine Growth

scholarly journals Glucose Replacement to Euglycemia Causes Hypoxia, Acidosis, and Decreased Insulin Secretion in Fetal Sheep With Intrauterine Growth Restriction

2009 ◽  
Vol 65 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Paul J Rozance ◽  
Sean W Limesand ◽  
James S Barry ◽  
Laura D Brown ◽  
William W Hay
Keyword(s):  
Insulin Secretion ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Fetal Sheep ◽  
Intrauterine Growth

scholarly journals Increased Hepatic Glucose Production in Fetal Sheep With Intrauterine Growth Restriction Is Not Suppressed by Insulin

Diabetes ◽  
2012 ◽  
Vol 62 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Stephanie R. Thorn ◽  
Laura D. Brown ◽  
Paul J. Rozance ◽  
William W. Hay ◽  
Jacob E. Friedman
Keyword(s):  
Intrauterine Growth Restriction ◽  
Hepatic Glucose Production ◽  
Glucose Production ◽  
Growth Restriction ◽  
Fetal Sheep ◽  
Intrauterine Growth ◽  
Hepatic Glucose

Effects of intrauterine growth restriction on lung liquid dynamics and lung development in fetal sheep

2001 ◽  
Vol 184 (2) ◽  
pp. 209-216 ◽  
Author(s):  
Megan L. Cock ◽  
Cheryl A. Albuquerque ◽  
Belinda J. Joyce ◽  
Stuart B. Hooper ◽  
Richard Harding
Keyword(s):  
Intrauterine Growth Restriction ◽  
Lung Development ◽  
Growth Restriction ◽  
Fetal Sheep ◽  
Intrauterine Growth ◽  
Lung Liquid ◽  
Liquid Dynamics

Intrauterine growth restriction leads to changes in sulfur amino acid metabolism in piglets

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Robert F Bertolo ◽  
Julie D Brophy ◽  
Semone B Myrie
Keyword(s):  
Amino Acid ◽  
Intrauterine Growth Restriction ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Growth Restriction ◽  
Sulfur Amino Acid ◽  
Intrauterine Growth

scholarly journals Altered Placental and Fetal Expression of IGFs and IGF-Binding Proteins Associated With Intrauterine Growth Restriction in Fetal Sheep During Early and Mid-Pregnancy

2006 ◽  
Vol 60 (5) ◽  
pp. 507-512 ◽  
Author(s):  
Barbra de Vrijer ◽  
Meredith L Davidsen ◽  
Randall B Wilkening ◽  
Russell V Anthony ◽  
Timothy R H Regnault
Keyword(s):  
Intrauterine Growth Restriction ◽  
Binding Proteins ◽  
Growth Restriction ◽  
Igf Binding Proteins ◽  
Fetal Sheep ◽  
Intrauterine Growth ◽  
Igf Binding

Increased Stiffness of the Abdominal Aorta With Intrauterine Growth Restriction in the Near-Term Fetal Sheep

2012 ◽  
Author(s):  
Reuben Blair Dodson ◽  
Paul J. Rozance ◽  
Kendall S. Hunter ◽  
Virginia L. Ferguson
Keyword(s):  
Abdominal Aorta ◽  
Intrauterine Growth Restriction ◽  
Structural Changes ◽  
Epidemiological Studies ◽  
Growth Restriction ◽  
Fetal Sheep ◽  
Intrauterine Growth ◽  
Systemic Artery ◽  
Artery Stiffness ◽  
Near Term

Fetal intrauterine growth restriction (IUGR) results in increased placental resistance to blood flow, fetal hypertension and increased pulsatility [1]. These hemodynamic changes have been shown to lead to vascular remodeling in adolescents and adults [2, 3] but have received little study of its effect during this critical period of vascular formation. Epidemiological studies link IUGR to cardiovascular disease in adulthood [4], but the reason for this is not clearly understood. Here, we examine a large elastic artery for developmental alterations under hypertensive conditions. We hypothesize that fetal hypertension induces abdominal aorta (AA) stiffening in the fetal ovine model of IUGR and that the increased systemic artery stiffness is due to altered extracellular matrix (ECM) composition and structural changes.

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