Naked mole‐rat brain mitochondria tolerate in vitro ischaemia

2021 ◽  
Author(s):  
Hang Cheng ◽  
Matthew E. Pamenter
Keyword(s):  
Rat Brain ◽  
Brain Mitochondria ◽  
Rat Brain Mitochondria ◽  
Mole Rat ◽  
Naked Mole Rat

scholarly journals Naked mole rat brain mitochondria electron transport system flux and H+leak are reduced during acute hypoxia

2017 ◽  
Vol 221 (4) ◽  
pp. jeb171397 ◽  
Author(s):  
Matthew E. Pamenter ◽  
Gigi Y. Lau ◽  
Jeffrey G. Richards ◽  
William K. Milsom
Keyword(s):  
Electron Transport ◽  
Rat Brain ◽  
Transport System ◽  
Acute Hypoxia ◽  
Brain Mitochondria ◽  
Electron Transport System ◽  
Rat Brain Mitochondria ◽  
Mole Rat ◽  
Naked Mole Rat

Respiratory Activity of Isolated Rat Brain Mitochondria following in vitro Exposure to Oxygen Radicals

1983 ◽  
Vol 3 (2) ◽  
pp. 207-214 ◽  
Author(s):  
Lars Hillered ◽  
Lars Ernster
Keyword(s):  
Xanthine Oxidase ◽  
Rat Brain ◽  
Oxygen Radicals ◽  
Respiratory Activity ◽  
Brain Mitochondria ◽  
Iron Chelate ◽  
Rat Brain Mitochondria ◽  
In Vitro Exposure ◽  
Isolated Rat

Respiratory activity of isolated rat brain mitochondria was measured following in vitro exposure to oxygen radicals. The radicals were generated by hypoxanthine and xanthine oxidase in the presence of a suitable iron chelate and caused a severe inhibition of respiration stimulated by phosphate plus ADP (with malate + glutamate as substrate). The damage could be prevented by catalase or high concentrations of mannitol, but not by superoxide dismutase. A similar effect was observed when hypoxanthine and xanthine oxidase were replaced by glucose and glucose oxidase or by hydrogen peroxide. Most of the findings indicate that the hydroxyl radical is the damaging agent. It is concluded that brain mitochondria exposed to oxygen radicals in vitro show an inhibition of respiratory activity similar to that reported by other investigators as occurring in mitochondria in vivo following transient cerebral ischemia. Therefore, oxygen radicals may contribute to this type of cell damage.

Effects of Aluminium on Rat Brain Mitochondria Bioenergetics: an In vitro and In vivo Study

2016 ◽  
Vol 54 (1) ◽  
pp. 563-570 ◽  
Author(s):  
Javier Iglesias-González ◽  
Sofía Sánchez-Iglesias ◽  
Andrés Beiras-Iglesias ◽  
Estefanía Méndez-Álvarez ◽  
Ramón Soto-Otero
Keyword(s):  
Rat Brain ◽  
Brain Mitochondria ◽  
In Vivo Study ◽  
Rat Brain Mitochondria

scholarly journals Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage in vitro

Aging ◽  
2020 ◽  
Vol 12 (21) ◽  
pp. 22266-22290
Author(s):  
Daniel Frankel ◽  
Matthew Davies ◽  
Bharat Bhushan ◽  
Yavuz Kulaberoglu ◽  
Paulina Urriola-Munoz ◽  
...  
Keyword(s):  
Rat Brain ◽  
Amyloid Beta ◽  
Lipid Membranes ◽  
Brain Lipid ◽  
Mole Rat ◽  
Naked Mole Rat

Effect of phencyclidine on oxygen consumption of rat brain mitochondria in vitro and in vivo

1973 ◽  
Vol 22 (13) ◽  
pp. 1661-1665 ◽  
Author(s):  
S. Millo ◽  
A. Chari-Bitron
Keyword(s):  
Oxygen Consumption ◽  
Rat Brain ◽  
Brain Mitochondria ◽  
Rat Brain Mitochondria

In vitro oxidation of vitamin E, vitamin C, thiols and cholesterol in rat brain mitochondria incubated with free radicals

1995 ◽  
Vol 26 (5) ◽  
pp. 527-535 ◽  
Author(s):  
G.T. Vatassery ◽  
W.E. Smith ◽  
H.T. Quach ◽  
J.C.K. Lai
Keyword(s):  
Free Radicals ◽  
Vitamin E ◽  
Vitamin C ◽  
Rat Brain ◽  
Brain Mitochondria ◽  
Rat Brain Mitochondria

scholarly journals Protein Synthesis by Isolated Rat Brain Mitochondria and Synaptosomes

1968 ◽  
Vol 243 (16) ◽  
pp. 4222-4226
Author(s):  
M W Gordon ◽  
G G Deanin
Keyword(s):  
Protein Synthesis ◽  
Rat Brain ◽  
Brain Mitochondria ◽  
Rat Brain Mitochondria ◽  
Isolated Rat

Distribution of glutathione peroxidases glutathione reductase in rat brain mitochondria

FEBS Letters ◽  
1991 ◽  
Vol 290 (1-2) ◽  
pp. 35-37 ◽  
Author(s):  
Enrico Panfili ◽  
Gabriella Sandri ◽  
Lars Ernster
Keyword(s):  
Glutathione Reductase ◽  
Rat Brain ◽  
Brain Mitochondria ◽  
Rat Brain Mitochondria ◽  
Glutathione Peroxidases
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