scholarly journals Mechanisms of functional recovery and regeneration after spinal cord transection in larval sea lamprey.

1978 ◽  
Vol 277 (1) ◽  
pp. 395-408 ◽  
Author(s):  
M E Selzer
Keyword(s):  
Spinal Cord ◽  
Functional Recovery ◽  
Sea Lamprey ◽  
Spinal Cord Transection

scholarly journals Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0138705 ◽  
Author(s):  
Chu-Hsun Cheng ◽  
Chi-Te Lin ◽  
Meng-Jen Lee ◽  
May-Jywan Tsai ◽  
Wen-Hung Huang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Functional Recovery ◽  
Local Delivery ◽  
Acute Stage ◽  
Spinal Cord Transection ◽  
High Dose ◽  
Axonal Outgrowth ◽  
Chondroitinase Abc

Local Injection of Lentivirus Encoding LINGO-1-shRNA Promotes Functional Recovery in Rats With Complete Spinal Cord Transection

Spine ◽  
2013 ◽  
Vol 38 (19) ◽  
pp. 1632-1639 ◽  
Author(s):  
Jingsheng Cen ◽  
Hongfu Wu ◽  
Jue Wang ◽  
Xianyue Ren ◽  
Hongwu Zhang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Functional Recovery ◽  
Spinal Cord Transection ◽  
Local Injection

Anatomical and functional recovery folloing spinal cord transection in the chick embryo

1990 ◽  
Vol 21 (6) ◽  
pp. 918-937 ◽  
Author(s):  
I. Shimizu ◽  
R. W. Oppenheim ◽  
M. O'Brien ◽  
A. Shneiderman
Keyword(s):  
Spinal Cord ◽  
Chick Embryo ◽  
Functional Recovery ◽  
Spinal Cord Transection

scholarly journals Author response: Spinal microcircuits comprising dI3 interneurons are necessary for motor functional recovery following spinal cord transection

2016 ◽  
Author(s):  
Tuan V Bui ◽  
Nicolas Stifani ◽  
Turgay Akay ◽  
Robert M Brownstone
Keyword(s):  
Spinal Cord ◽  
Functional Recovery ◽  
Spinal Cord Transection ◽  
Author Response

Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection

2022 ◽  
Author(s):  
Joana Nogueira-Rodrigues ◽  
Sérgio C. Leite ◽  
Rita Pinto-Costa ◽  
Sara C. Sousa ◽  
Liliana L. Luz ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Functional Recovery ◽  
Spinal Cord Transection ◽  
Spiny Mice

Modified acellular nerve-delivering PMSCs improve functional recovery in rats after complete spinal cord transection

2017 ◽  
Vol 5 (12) ◽  
pp. 2480-2492 ◽  
Author(s):  
Ting Tian ◽  
Zhenhai Yu ◽  
Naili Zhang ◽  
Yingwei Chang ◽  
Yuqiang Zhang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Spinal Cord Transection ◽  
Regeneration Capacity ◽  
The Poor ◽  
Cord Injury ◽  
Spontaneous Regeneration

Due to the poor regeneration capacity of neurons and the inhibitory microenvironment, spontaneous regeneration in spinal cord injury (SCI) remains challenging.

Expression of the Netrin Receptor UNC-5 in Lamprey Brain: Modulation by Spinal Cord Transection

2000 ◽  
Vol 14 (1) ◽  
pp. 49-58 ◽  
Author(s):  
M.I. Shifman ◽  
M.E. Selzer
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Sea Lamprey ◽  
Spinal Cord Transection ◽  
Reticulospinal Neurons ◽  
Cns Regeneration ◽  
Developmental Guidance ◽  
Guidance Cues

The sea lamprey recovers from spinal cord transection by a process that involves directionally specific regeneration of axons. The mechanisms underlying this speci ficity are not known, but they may involve molecular cues similar to those that guide the growth of spinal cord axons during development, such as netrins and semaphorins. To test the role of guidance cues in regeneration, we cloned netrin and its receptor UNC-5 from lamprey central nervous system (CNS) and studied their expression after spinal cord transection. In situ hybridization showed that (1) mRNA for netrin is ex pressed in the spinal cord, primarily in neurons of the lateral gray matter and in dor sal cells; (2) mRNA for UNC-5 is expressed in lamprey reticulospinal neurons; (3) fol lowing spinal cord transection, UNC-5 message was dramatically downregulated at two weeks, during the period of axon dieback; (4) UNC-5 message was upregulated at three weeks, when many axons are beginning to regenerate; and (5) axotomy-in duced expression of UNC-5 occurred primarily in neurons whose axons regenerate poorly. Because the UNC-5 receptor is thought to mediate the chemorepellent ef fects of netrins, netrin signaling may play a role in limiting or channeling the regen eration of certain neurons. These data strengthen the rationale for studying the role of developmental guidance molecules in CNS regeneration.

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