scholarly journals Kinetic characterization of the voltage-gated currents possessed by Xenopus embryo spinal neurons.

1995 ◽  
Vol 489 (2) ◽  
pp. 473-488 ◽  
Author(s):  
N Dale
Keyword(s):  
Xenopus Embryo ◽  
Kinetic Characterization ◽  
Spinal Neurons ◽  
Voltage Gated

Kinetic Characterization of Anticarsia gemmatalis Digestive Serine- Proteases and the Inhibitory Effect of Synthetic Peptides

2018 ◽  
Vol 24 (11) ◽  
Author(s):  
Adriana M. Patarroyo-Vargas ◽  
Yaremis B. Merino-Cabrera ◽  
Jose C. Zanuncio ◽  
Francelina Rocha ◽  
Wellington G. Campos ◽  
...  
Keyword(s):  
Synthetic Peptides ◽  
Serine Proteases ◽  
Inhibitory Effect ◽  
Anticarsia Gemmatalis ◽  
Kinetic Characterization

scholarly journals Kinetic characterization of yeast alcohol dehydrogenases. Amino acid residue 294 and substrate specificity.

1987 ◽  
Vol 262 (8) ◽  
pp. 3754-3761
Author(s):  
A.J. Ganzhorn ◽  
D.W. Green ◽  
A.D. Hershey ◽  
R.M. Gould ◽  
B.V. Plapp
Keyword(s):  
Amino Acid ◽  
Substrate Specificity ◽  
Amino Acid Residue ◽  
Kinetic Characterization ◽  
Alcohol Dehydrogenases

scholarly journals Characterization of Direct Perturbations on Voltage-Gated Sodium Current by Esaxerenone, a Nonsteroidal Mineralocorticoid Receptor Blocker

Biomedicines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 549
Author(s):  
Wei-Ting Chang ◽  
Sheng-Nan Wu
Keyword(s):  
Mineralocorticoid Receptor ◽  
Sodium Current ◽  
Ionic Currents ◽  
Antagonistic Effect ◽  
Gh3 Cells ◽  
Excitable Cells ◽  
Voltage Gated ◽  
Ic50 Value ◽  
Low Threshold

Esaxerenone (ESAX; CS-3150, Minnebro®) is known to be a newly non-steroidal mineralocorticoid receptor (MR) antagonist. However, its modulatory actions on different types of ionic currents in electrically excitable cells remain largely unanswered. The present investigations were undertaken to explore the possible perturbations of ESAX on the transient, late and persistent components of voltage-gated Na+ current (INa) identified from pituitary GH3 or MMQ cells. GH3-cell exposure to ESAX depressed the transient and late components of INa with varying potencies. The IC50 value of ESAX required for its differential reduction in peak or late INa in GH3 cells was estimated to be 13.2 or 3.2 μM, respectively. The steady-state activation curve of peak INa remained unchanged during exposure to ESAX; however, recovery of peak INa block was prolonged in the presence 3 μM ESAX. In continued presence of aldosterone (10 μM), further addition of 3 μM ESAX remained effective at inhibiting INa. ESAX (3 μM) potently reversed Tef-induced augmentation of INa. By using isosceles-triangular ramp pulse with varying durations, the amplitude of persistent INa measured at high or low threshold was enhanced by the presence of tefluthrin (Tef), in combination with the appearance of the figure-of-eight hysteretic loop; moreover, hysteretic strength of the current was attenuated by subsequent addition of ESAX. Likewise, in MMQ lactotrophs, the addition of ESAX also effectively decreased the peak amplitude of INa along with the increased current inactivation rate. Taken together, the present results provide a noticeable yet unidentified finding disclosing that, apart from its antagonistic effect on MR receptor, ESAX may directly and concertedly modify the amplitude, gating properties and hysteresis of INa in electrically excitable cells.

Kinetic characterization of a slow-binding inhibitor of Bla2: thiomaltol

2012 ◽  
Vol 28 (1) ◽  
pp. 137-142 ◽  
Author(s):  
Sara R. Schlesinger ◽  
Britain Bruner ◽  
Patrick J. Farmer ◽  
Sung-Kun Kim
Keyword(s):  
Kinetic Characterization ◽  
Slow Binding Inhibitor

Preparation and kinetic characterization of copolymers of acrylamide and poly(ethylene glycol) (meth)acrylate macromonomers

Polymer ◽  
1996 ◽  
Vol 37 (7) ◽  
pp. 1201-1209 ◽  
Author(s):  
Huining Xiao ◽  
Robert Pelton ◽  
Archie Hamielec
Keyword(s):  
Ethylene Glycol ◽  
Kinetic Characterization ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Molecular characterization of a two-domain form of the neuronal voltage-gated P/Q-type calcium channel α1 2.1 subunit

FEBS Letters ◽  
2002 ◽  
Vol 532 (3) ◽  
pp. 300-308 ◽  
Author(s):  
Jyothi Arikkath ◽  
Ricardo Felix ◽  
Christopher Ahern ◽  
Chien-Chang Chen ◽  
Yasuo Mori ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Molecular Characterization ◽  
Voltage Gated

scholarly journals Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats

2011 ◽  
Vol 165 (2) ◽  
pp. 168-177 ◽  
Author(s):  
Marie Louise M. Ghorbani ◽  
Chao Qin ◽  
Mingyuan Wu ◽  
Jay P. Farber ◽  
Majid Sheykhzade ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Spinal Neurons ◽  
Thoracic Spinal ◽  
Upper Thoracic
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