scholarly journals Human blood-derived macrophages enhance barrier function of cultured primary bovine and human brain capillary endothelial cells

2003 ◽  
Vol 551 (3) ◽  
pp. 1023-1032 ◽  
Author(s):  
D. Zenker ◽  
D. Begley ◽  
H. Bratzke ◽  
H. Rubsamen-Waigmann ◽  
H. von Briesen
Keyword(s):  
Endothelial Cells ◽  
Human Brain ◽  
Human Blood ◽  
Barrier Function ◽  
Brain Capillary ◽  
Brain Capillary Endothelial Cells ◽  
Capillary Endothelial Cells

Studies of Plasmodium falciparum cytoadherence using immortalized human brain capillary endothelial cells

1996 ◽  
Vol 26 (6) ◽  
pp. 647-655 ◽  
Author(s):  
Jacques G. Prudhomme ◽  
Irwin W. Sherman ◽  
Kirkwood M. Land ◽  
Ashlee V. Moses ◽  
Stephan Stenglein ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Plasmodium Falciparum ◽  
Human Brain ◽  
Brain Capillary ◽  
Brain Capillary Endothelial Cells ◽  
Capillary Endothelial Cells

scholarly journals Major involvement of Na+ -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells

2015 ◽  
Vol 134 (1) ◽  
pp. 97-112 ◽  
Author(s):  
Yasuo Uchida ◽  
Katsuaki Ito ◽  
Sumio Ohtsuki ◽  
Yoshiyuki Kubo ◽  
Takashi Suzuki ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Human Brain ◽  
Pantothenic Acid ◽  
Brain Capillary ◽  
Brain Capillary Endothelial Cells ◽  
Capillary Endothelial Cells

scholarly journals Drug-Induced Trafficking of P-Glycoprotein in Human Brain Capillary Endothelial Cells as Demonstrated by Exposure to Mitomycin C

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88154 ◽  
Author(s):  
Andreas Noack ◽  
Sandra Noack ◽  
Andrea Hoffmann ◽  
Katia Maalouf ◽  
Manuela Buettner ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Human Brain ◽  
Mitomycin C ◽  
Drug Induced ◽  
Brain Capillary ◽  
Brain Capillary Endothelial Cells ◽  
P Glycoprotein ◽  
Capillary Endothelial Cells

Cultured human brain capillary endothelial cells are permissive for infection by human cytomegalovirus

Virology ◽  
1990 ◽  
Vol 176 (1) ◽  
pp. 266-273 ◽  
Author(s):  
Janet L. Lathey ◽  
Clayton A. Wiley ◽  
M.Anthony Verity ◽  
Jay A. Nelson
Keyword(s):  
Endothelial Cells ◽  
Human Brain ◽  
Human Cytomegalovirus ◽  
Brain Capillary ◽  
Brain Capillary Endothelial Cells ◽  
Capillary Endothelial Cells

scholarly journals Pericytes Regulate Fibrinolytic Function of Brain Capillary Endothelial Cells

Stroke ◽  
2001 ◽  
Vol 32 (suppl_1) ◽  
pp. 359-359
Author(s):  
Jeong A Kim ◽  
Nam D Tran ◽  
Shur-Jen Wang ◽  
Mark Fisher
Keyword(s):  
Endothelial Cells ◽  
Human Brain ◽  
Plasminogen Activator ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Regulatory Role ◽  
Brain Capillary ◽  
Brain Capillary Endothelial Cells ◽  
Brain Pericytes ◽  
Capillary Endothelial Cells

P110 Our prior work has shown that astrocytes inhibit fibrinolysis of brain capillary endothelial cells (eg, Stroke 1999:30;1671–1677). The complex cellular microenvironment at the blood-brain barrier includes pericytes, which are adjacent to and share basement membrane with brain capillary endothelial cells. We analyzed the hemostatic regulatory role of pericytes in a blood-brain barrier model consisting of human brain pericytes cultured on transwell membrane inserts with human brain capillary endothelial cells. We measured fibrinolysis proteins and function in media conditioned by 48 hour co-culture of human brain capillary endothelial cells and human brain pericytes, as well as brain capillary endothelial mono-cultures. Compared to endothelial mono-cultures, pericyte-endothelial co-cultures exhibited levels of tissue plasminogen activator (tPA) protein reduced by 50±15% (p<.05). Co-culture preparations showed 32±13% (p<.05) increase in levels of plasminogen activator inhibitor-1 (PAI-1) protein, the primary inhibitor of tPA. tPA activity of co-culture preparations was 54±17% (p<.05) of endothelial mono-culture preparations. These data demonstrate that human brain pericytes have an important hemostatic regulatory role for endothelial-dependent fibrinolysis in vitro. These findings provide further support for brain-specific hemostasis, with pericytes as well as astrocytes playing key regulatory roles.

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