scholarly journals Neuromuscular blockade of slow twitch muscle fibres elevates muscle oxygen uptake and energy turnover during submaximal exercise in humans

2008 ◽  
Vol 586 (24) ◽  
pp. 6037-6048 ◽  
Author(s):  
Peter Krustrup ◽  
Niels H. Secher ◽  
Mihai U. Relu ◽  
Ylva Hellsten ◽  
Karin Söderlund ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Neuromuscular Blockade ◽  
Submaximal Exercise ◽  
Muscle Fibres ◽  
Energy Turnover ◽  
Muscle Oxygen ◽  
Slow Twitch Muscle ◽  
Slow Twitch ◽  
Exercise In Humans ◽  
Muscle Oxygen Uptake

scholarly journals Muscle oxygen uptake and energy turnover during dynamic exercise at different contraction frequencies in humans

2001 ◽  
Vol 536 (1) ◽  
pp. 261-271 ◽  
Author(s):  
Richard A. Ferguson ◽  
Derek Ball ◽  
Peter Krustrup ◽  
Per Aagaard ◽  
Michael Kjær ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Dynamic Exercise ◽  
Energy Turnover ◽  
Muscle Oxygen ◽  
Muscle Oxygen Uptake

A model for studying the distortion of muscle oxygen uptake patterns by circulation parameters

1991 ◽  
Vol 62 (2) ◽  
pp. 83-90 ◽  
Author(s):  
D. Eβfeld ◽  
U. Hoffmann ◽  
J. Stegemann
Keyword(s):  
Oxygen Uptake ◽  
Muscle Oxygen ◽  
Circulation Parameters ◽  
Muscle Oxygen Uptake

Involvement of fast and slow twitch muscle fibres in avian muscular dystrophy

1983 ◽  
Vol 61 (2) ◽  
pp. 217-233 ◽  
Author(s):  
John A. Pizzey ◽  
Eric A. Barnard ◽  
Penelope J. Barnard
Keyword(s):  
Muscular Dystrophy ◽  
Muscle Fibres ◽  
Slow Twitch Muscle ◽  
Slow Twitch

Model of oxygen transport and metabolism predicts effect of hyperoxia on canine muscle oxygen uptake dynamics

2007 ◽  
Vol 103 (4) ◽  
pp. 1366-1378 ◽  
Author(s):  
Nicola Lai ◽  
Gerald M. Saidel ◽  
Bruno Grassi ◽  
L. Bruce Gladden ◽  
Marco E. Cabrera
Keyword(s):  
Experimental Data ◽  
Oxygen Uptake ◽  
Oxygen Content ◽  
Oxygen Transport ◽  
Mechanistic Model ◽  
Arterial Oxygen ◽  
Cellular Respiration ◽  
Arterial Oxygen Content ◽  
Muscle Oxygen ◽  
Muscle Oxygen Uptake

Previous studies have shown that increased oxygen delivery, via increased convection or arterial oxygen content, does not speed the dynamics of oxygen uptake, V̇o2m, in dog muscle electrically stimulated at a submaximal metabolic rate. However, the dynamics of transport and metabolic processes that occur within working muscle in situ is typically unavailable in this experimental setting. To investigate factors affecting V̇o2m dynamics at contraction onset, we combined dynamic experimental data across working muscle with a mechanistic model of oxygen transport and metabolism in muscle. The model is based on dynamic mass balances for O2, ATP, and PCr. Model equations account for changes in cellular ATPase, oxidative phosphorylation, and creatine kinase fluxes in skeletal muscle during exercise, and cellular respiration depends on [ADP] and [O2]. Model simulations were conducted at different levels of arterial oxygen content and blood flow to quantify the effects of convection and diffusion of oxygen on the regulation of cellular respiration during step transitions from rest to isometric contraction in dog gastrocnemius muscle. Simulations of arteriovenous O2 differences and V̇o2m dynamics were successfully compared with experimental data (Grassi B, Gladden LB, Samaja M, Stary CM, Hogan MC. J Appl Physiol 85: 1394–1403, 1998; and Grassi B, Gladden LB, Stary CM, Wagner PD, Hogan MC. J Appl Physiol 85: 1404–1412, 1998), thus demonstrating the validity of the model, as well as its predictive capability. The main findings of this study are: 1) the estimated dynamic response of oxygen utilization at contraction onset in muscle is faster than that of oxygen uptake; and 2) hyperoxia does not accelerate the dynamics of diffusion and consequently muscle oxygen uptake at contraction onset due to the hyperoxia-induced increase in oxygen stores. These in silico derived results cannot be obtained from experimental observations alone.

Non-invasive estimation of muscle oxygen uptake kinetics with pseudorandom binary sequence and step exercise responses

2017 ◽  
Vol 118 (2) ◽  
pp. 429-438 ◽  
Author(s):  
Uwe Drescher ◽  
R. Schmale ◽  
J. Koschate ◽  
L. Thieschäfer ◽  
T. Schiffer ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Binary Sequence ◽  
Oxygen Uptake Kinetics ◽  
Uptake Kinetics ◽  
Pseudorandom Binary Sequence ◽  
Muscle Oxygen ◽  
Non Invasive ◽  
Muscle Oxygen Uptake

scholarly journals Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activity

Development ◽  
2008 ◽  
Vol 135 (12) ◽  
pp. 2115-2126 ◽  
Author(s):  
S. Elworthy ◽  
M. Hargrave ◽  
R. Knight ◽  
K. Mebus ◽  
P. W. Ingham
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Muscle Fibres ◽  
Slow Myosin ◽  
Slow Myosin Heavy Chain ◽  
Slow Twitch Muscle ◽  
Myosin Heavy Chain Genes ◽  
Slow Twitch

Nutritional status affects branched-chain oxoacid dehydrogenase activity during exercise in humans

1997 ◽  
Vol 272 (2) ◽  
pp. E233-E238 ◽  
Author(s):  
M. L. Jackman ◽  
M. J. Gibala ◽  
E. Hultman ◽  
T. E. Graham
Keyword(s):  
Amino Acid ◽  
Oxygen Uptake ◽  
Muscle Glycogen ◽  
Random Order ◽  
Submaximal Exercise ◽  
The Other ◽  
Branched Chain Amino Acid ◽  
Low Carbohydrate ◽  
Branched Chain ◽  
Exercise In Humans

We examined the effect of glycogen availability and branched-chain amino acid (BCAA) supplementation on branched-chain oxoacid dehydrogenase (BCOAD) activity during exercise. Six subjects cycled at approximately 75% of their maximal oxygen uptake to exhaustion on three occasions under different preexercise conditions: 1) low muscle glycogen (LOW), 2) low muscle glycogen plus BCAA supplementation (LOW+BCAA), and 3) high muscle glycogen (CON). The LOW trial was performed first, followed by the other two conditions in random order, and biopsies for all trials were obtained at rest, after 15 min of exercise (15 min), and at the point of exhaustion during the LOW trial (49 min). BCOAD activity was not different among the three conditions at rest; however, at 15 min BCOAD activity was higher (P < or = 0.05) for the LOW (31 +/- 5%) and LOW+BCAA (43 +/- 11%) conditions compared with CON (12 +/- 1%). BCOAD activity at 49 min was not different from respective values at 15 min for any condition. These data indicate that BCOAD is rapidly activated during submaximal exercise under conditions associated with low carbohydrate availability. However, there was no relationship between BCOAD activity and glycogen concentration or net glycogenolysis, which suggests that factors other than glycogen availability are important for BCOAD regulation during exercise in humans.

scholarly journals Skeletal Muscle Oxygen Uptake Dynamics during the Exercise Off‐Transient

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Brad J Behnke ◽  
Leonardo F Ferreira ◽  
Timothy I Musch ◽  
David C Poole
Keyword(s):  
Skeletal Muscle ◽  
Oxygen Uptake ◽  
Muscle Oxygen ◽  
Muscle Oxygen Uptake

MUSCLE OXYGEN UPTAKE IN CHRONIC HEART FAILURE 1006

1997 ◽  
Vol 29 (Supplement) ◽  
pp. 176
Author(s):  
Akiko Hanada ◽  
Kouichi Okita ◽  
Kazuya Yonezawa ◽  
Mitsunori Ohtsubo ◽  
Akira Kitabatake ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Oxygen Uptake ◽  
Muscle Oxygen ◽  
Muscle Oxygen Uptake
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