Preliminary Evaluation of Hydraulic Needle Delivery System for MRI Guided Prostate Biopsy Procedures

2021 ◽  
Author(s):  
Davut Ibrahim Mahcicek ◽  
Dursun Korel Yildirim ◽  
Gokce Kasaci ◽  
Ozgur Kocaturk
Keyword(s):  
Delivery System ◽  
Prostate Biopsy ◽  
Transrectal Ultrasound ◽  
Preliminary Evaluation ◽  
Biopsy Needle ◽  
Biopsy Procedure ◽  
Mri Guidance ◽  
Diagnose Prostate Cancer ◽  
Mri Guided

Abstract In clinical routine, the prostate biopsy procedure is performed with the guidance of transrectal ultrasound (TRUS) imaging to diagnose prostate cancer. However, the TRUS-guided prostate biopsy brings reliability concerns due to the lack of contrast difference between prostate tissue and lesions. In this study, a novel hydraulic needle delivery system that is designed for performing MRI-guided prostate biopsy procedure with transperineal approach is introduced. The feasibility of the overall system was evaluated through in-vitro phantom experiments under an MRI guidance. The in vitro experiments performed using a certified prostate phantom (incorporating MRI visible lesions). MRI experiments showed that overall hydraulic biopsy needle delivery system has excellent MRI compatibility (SNR Loss < 3%), provides acceptable targeting accuracy (average 2.05±0.46 mm) and procedure time (average 40 minutes).

In vitro validation of a 3-dimensional transrectal ultrasound system for prostate biopsiess

2007 ◽  
Vol 30 (4) ◽  
pp. 77
Author(s):  
Derek Cool ◽  
Shi Sherebrin ◽  
Jonathan Izawa ◽  
Joseph Chin ◽  
Aaron Fenster
Keyword(s):  
Prostate Biopsy ◽  
3D Model ◽  
Transrectal Ultrasound ◽  
Surface Topology ◽  
Sufficient Information ◽  
Needle Guidance ◽  
3 Dimensional ◽  
High Incidence ◽  
3D Information

Introduction: Transrectal ultrasound (TRUS) prostate biopsy (Bx) is currently confined to 2D information to both target and record 3D Bx locations. Accurate placement of Bx needles cannot be verified without 3D information, and recording Bx sites in 2D does not provide sufficient information to accurately guide the high incidence of repeat Bx. We have designed a 3D TRUS prostate Bx system that augments the current 2D TRUS system and provides tools for biopsy-planning, needle guidance, and recording of the biopsy core locations entirely in 3D. Methods: Our Bx system displays a 3D model of the patient’s prostate, which is generated intra-procedure from a collection of 2D TRUS images, representative of the particular prostate shape. Bx targets are selected, needle guidance is facilitated, and 3D Bx sites are recorded within the 3D context of the prostate model. The complete 3D Bx system was validated, in vitro, by performing standard ten-core Bx on anatomical phantoms of two patient’s prostates. The accuracy of the needle-guidance, Bx location recording, and 3D model volume and surface topology were validated against a CT gold standard. Results: The Bx system successfully reconstructed the 3D patient prostate models with a mean volume error of 3.2 ± 7.6%. Using the 3D system, needles were accurately guided to the pre-determined targets with a mean error of 2.26 ± 1.03 mm and the 3D locations of the Bx cores were accurately recorded with a mean distance error of 1.47 ± 0.79 mm. Conclusion: We have successfully developed a 3D TRUS prostate biopsy system and validated the system in vitro. A pilot study has been initiated to apply the system clinically.

First Place: Sustained-Release Antibacterial Varnish-Coated Biopsy Needle for Reduction of Infection Rates Following Prostate Biopsy—In Vitro Model

2013 ◽  
Vol 27 (3) ◽  
pp. 277-283 ◽  
Author(s):  
Gideon Lorber ◽  
Mordechai Duvdevani ◽  
Michael Friedman ◽  
Eran Lavy ◽  
Ezekiel H. Landau ◽  
...  
Keyword(s):  
Sustained Release ◽  
Prostate Biopsy ◽  
In Vitro Model ◽  
Infection Rates ◽  
Biopsy Needle ◽  
Vitro Model

Disinfection of a Probe Used in Ultrasound-Guided Prostate Biopsy

2007 ◽  
Vol 28 (8) ◽  
pp. 916-919 ◽  
Author(s):  
William A. Rutala ◽  
Maria F. Gergen ◽  
David J. Weber
Keyword(s):  
Prostate Biopsy ◽  
Bacterial Load ◽  
Transrectal Ultrasound ◽  
Diagnostic Procedures ◽  
Ultrasound Probe ◽  
Ultrasound Guided ◽  
Biopsy Needle ◽  
Prostate Biopsies ◽  
Colony Forming Units ◽  
High Level

Background.Transrectal ultrasound (TRUS)-guided prostate biopsies are among the most common outpatient diagnostic procedures in urology clinics and carry the risk of introducing pathogens that may lead to infection.Objective.To investigate the effectiveness of procedures for disinfecting a probe used in ultrasound-guided prostate biopsy.Method.The effectiveness of disinfection was determined by inoculating 107 colony forming units (cfu) of Pseudomonas aeruginosa at the following 3 sites on the probe: the interior lumen of the biopsy needle guide, the outside surface of the biopsy needle guide, and the interior lumen of the ultrasound probe where the needle guide passes through the transducer. Each site was investigated separately. After inoculation, the probe was immersed in 2% glutaraldehyde for 20 minutes and then assessed for the level of microbial contamination.Results.The results demonstrated that disinfection (ie, a reduction in bacterial load of greater than 7 log10 cfu) could be achieved if the needle guide was removed from the probe. However, if the needle guide was left in the probe channel during immersion in 2% glutaraldehyde, disinfection was not achieved (ie, the reduction was approximately 1 log10 cfu).Conclusions.Recommendations for probe disinfection are provided and include disassembling the device and immersing the probe and the needle guide separately in a high-level disinfectant.

scholarly journals Evaluation of robot-assisted MRI-guided prostate biopsy: needle path analysis during clinical trials

2018 ◽  
Vol 63 (20) ◽  
pp. 20NT02 ◽  
Author(s):  
Pedro Moreira ◽  
Niravkumar Patel ◽  
Marek Wartenberg ◽  
Gang Li ◽  
Kemal Tuncali ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Path Analysis ◽  
Prostate Biopsy ◽  
Robot Assisted ◽  
Biopsy Needle ◽  
Needle Path ◽  
Mri Guided

Preliminary evaluation of a novel oral delivery system for rhPTH1-34: In vitro and in vivo

2011 ◽  
Vol 420 (1) ◽  
pp. 172-179 ◽  
Author(s):  
Liting Guo ◽  
Erli Ma ◽  
Haiwei Zhao ◽  
Yingfang Long ◽  
Changxue Zheng ◽  
...  
Keyword(s):  
Delivery System ◽  
Oral Delivery ◽  
Preliminary Evaluation ◽  
Oral Delivery System

scholarly journals Prostate biopsy: a survey of practice among Nigerian urologists

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Taofiq O. Mohammed ◽  
Abdulwahab A. Ajape ◽  
Suleiman A. Kuranga ◽  
Hamid B. Olanipekun ◽  
Tolulope T. Ogunfowora
Keyword(s):  
Bowel Preparation ◽  
Prostate Biopsy ◽  
Transrectal Ultrasound ◽  
Prophylactic Antibiotic ◽  
General Meeting ◽  
Scientific Conference ◽  
Prostate Needle Biopsy ◽  
Transrectal Biopsy ◽  
Left Lateral Decubitus Position ◽  
Mri Guided

Abstract Background Prostate biopsy is a commonly performed outpatient procedure in urology. It is a rapidly changing field with wide variation in practice pattern. The aim of this study is to document the current practice of prostate biopsy among Nigerian urologists. Methods A prospectively designed, self-administered, 16-item survey questionnaire was distributed among urologists and trainees at the 24th Annual General Meeting and Scientific Conference of the Nigerian Association of Urological Surgeons (NAUS). The survey covers various aspect of prostate biopsy including indications for biopsy, prophylactic antibiotic regimen use, methods of bowel preparation, number of biopsy cores taken, complications among others. Results Fifty-one completed questionnaires were returned, out of 76 distributed, giving a response rate of 67%. Majority of the respondents were Consultant urologist 47 (92%), most of them practice in the public health system 46 (90.2%), and performed more than 5 prostate needle biopsy per month 37 (72.5%). All respondents administer prophylactic antibiotics prior to biopsy, with intravenous Gentamycin being the most commonly administered prophylactics 14 (27.5%), only a few perform bowel preparations prior to biopsy 8 (15.7%) with Dulcolax suppository being the most commonly employed agents 5 (63%). Most of the biopsy were done under transrectal ultrasound guidance 29 (56.9%). None of the respondents performed MRI-guided transrectal biopsy. Most respondents take 8–12 core biopsy 20 (39.2%), using 18G trucut biopsy needle 31 (60.8%), with the patient in left lateral decubitus position 26 (51%), under 2% intrarectal xylocaine instillation 28 (54.9%). The commonest complication after the procedure was bleeding per rectum 20 (39.2%), followed by haematuria 9 (17.6%), and infection 8 (15.7%). Conclusion There is universal use of prophylactic antibiotic prior to biopsy. However, bowel preparation prior to biopsy is not common among Nigerian urologist, and MRI-guided biopsy is very rarely done for prostate biopsy. There is need for a prostate biopsy guideline among Nigerian urologists to ensure uniformity of practice, and enhance standardized service delivery.

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