Biomedical Devices Using Shape Memory Polymer Foams for Treatment of Intracranial Aneurysms

2018 ◽  
Author(s):  
Jingyu Wang ◽  
Jishan Luo ◽  
Robert Kunkel ◽  
Yingtao Liu ◽  
Bradley Bohnstedt ◽  
...  
Keyword(s):  
Shape Memory ◽  
Intracranial Aneurysms ◽  
Shape Recovery ◽  
Shape Memory Polymer ◽  
Endovascular Embolization ◽  
Polymer Foams ◽  
Biomedical Devices ◽  
Successful Completion ◽  
Triggering Mechanism ◽  
Solid Foundation

This paper presents a novel medical device developed using shape memory polymer (SMP) foams for the endovascular treatment of intracranial aneurysms (ICAs). The SMP foam is fabricated, characterized, and experimentally investigated to better understand their potential for endovascular embolization of ICAs. Polyurethane-based SMP is successfully synthesized and characterized. The SMP foam is manufactured using cast molding, and characterized using an electro-thermal triggering mechanism to fully understand their shape recovery capability. The successful completion of this work will serve as a solid foundation for the development of new biomedical devices to treat intracranial aneurysms and develop an optimal releasing procedure for future animal study.

Highly Porous Shape Memory Nanocomposites for Applications in Biomedical Devices

2019 ◽  
Author(s):  
Jishan Luo ◽  
Robert Kunkel ◽  
Jingyu Wang ◽  
Bradley N. Bohnstedt ◽  
Mrinal Saha ◽  
...  
Keyword(s):  
Shape Memory ◽  
Coil Embolization ◽  
Intracranial Aneurysms ◽  
Endovascular Embolization ◽  
Biomedical Devices ◽  
Risk Of Rupture ◽  
Endovascular Coil Embolization ◽  
Brain Artery ◽  
Porous Nanocomposites ◽  
Highly Porous

Abstract This paper presents the novel development of highly porous carbon nanotube (CNT)/shape memory polymer (SMP) nanocomposites for potential endovascular treatment of intracranial aneurysms (ICAs). Intracranial aneurysm is a cerebrovascular disorder that can significantly weaken the wall of a brain artery, resulting in a localized dilation of the blood vessel with risk of rupture and subarachnoid bleeding. Current therapeutic options include surgical clipping and endovascular coil embolization. Clipping of intracranial aneurysms is invasive, and, therefore, it has gradually been replaced by non-invasive endovascular embolization. Recent studies have shown that aneurysmal recanalization and incomplete occlusion are still emerging clinical challenges in endovascular coil embolization. Therefore, there is an urgent need to develop new medical devices and surgical procedure to treat intracranial aneurysms with improved long-term outcomes. CNT/SMP nanocomposites are fabricated by directly coating CNTs on sugar particles before fabricating the sugar template for porous nanocomposites. Pristine SMP prepolymer is infiltrated into the pores of sugar template. All the sugar is dissolved in water after the fully curing of PDMS, resulting in SMP based nanocomposites with well dispersed CNTs. The porous nanocomposites are characterized to identify key parameters, such as electrical resistivity and shape memory capability. A resistive-heating mechanism is developed to trigger shape recovery of the nanocomposites. The results of this work will lay a solid foundation for our subsequent development of new personalized biomedical devices to treat ICAs using a catheter-based endovascular embolization procedure.

Out-of-Autoclave Repair of Composite Laminates by Using Shape Memory Polymer Foams

2019 ◽  
Author(s):  
D. Bellisario ◽  
F. Quadrini ◽  
L. Santo ◽  
L. Iorio ◽  
N. Gallo ◽  
...  
Keyword(s):  
Shape Memory ◽  
Composite Laminates ◽  
Shape Recovery ◽  
Shape Memory Polymer ◽  
Production Equipment ◽  
Polymer Foams ◽  
The Poor ◽  
Compression Strain ◽  
Out Of Autoclave ◽  
The Cost

Abstract Composite repairing is an issue because of the size of the parts, the cost of the production equipment and the poor consolidation between the parent part and the repairing patches. In this study an out-of-autoclave procedure is proposed where the agglomeration pressure is provided by shape memory foams. These foams can be shaped in the desired form by means of a thermos-mechanical cycle, and provide additional pressure if constrained during recovery. Shape recovery is achieved by using the same thermal cycle which is necessary for the cure of the patches. In this study, thermoplastic shape memory foams have been characterized to evaluate the agglomeration pressure they can provide as a function of the compression strain. In order to show the feasibility of their application, the cure of a composite laminate has been performed by using pre-shaped shape memory foams. Results show that a good consolidation is achieved despite of the absence of a vacuum bag.

Investigate of Electrical Conductivity of Shape-Memory Polymer Filled with Carbon Black

2008 ◽  
Vol 47-50 ◽  
pp. 714-717 ◽  
Author(s):  
Xin Lan ◽  
Jin Song Leng ◽  
Yan Ju Liu ◽  
Shan Yi Du
Keyword(s):  
Electrical Conductivity ◽  
Carbon Black ◽  
Shape Memory ◽  
Shape Recovery ◽  
Volume Fraction ◽  
Shape Memory Polymer ◽  
Recovery Process ◽  
Thermomechanical Properties ◽  
Electrically Conductive ◽  
New System

A new system of thermoset styrene-based shape-memory polymer (SMP) filled with carbon black (CB) is investigated. To realize the electroactive stimuli of SMP, the electrical conductivity of SMP filled with various amounts of CB is characterized. The percolation threshold of electrically conductive SMP filled with CB is about 3% (volume fraction of CB), which is much lower than many other electrically conductive polymers. When applying a voltage of 30V, the shape recovery process of SMP/CB(10 vol%) can be realized in about 100s. In addition, the thermomechanical properties are also characterized by differential scanning calorimetery (DSC).

scholarly journals Cover Feature: Multifunctional Shape-Memory Polymer Foams with Bio-inspired Antimicrobials (ChemPhysChem 16/2018)

ChemPhysChem ◽  
2018 ◽  
Vol 19 (16) ◽  
pp. 1936-1936
Author(s):  
Mary Beth Browning Monroe ◽  
Alexandra D. Easley ◽  
Katie Grant ◽  
Grace K. Fletcher ◽  
Calla Boyer ◽  
...  
Keyword(s):  
Shape Memory ◽  
Shape Memory Polymer ◽  
Polymer Foams

scholarly journals Electrical actuation and shape recovery control of shape-memory polymer nanocomposites

2013 ◽  
Vol 4 (3) ◽  
pp. 167-178 ◽  
Author(s):  
Fei Liang ◽  
Robert Sivilli ◽  
Jihua Gou ◽  
Yunjun Xu ◽  
Bob Mabbott
Keyword(s):  
Shape Memory ◽  
Polymer Nanocomposites ◽  
Shape Recovery ◽  
Shape Memory Polymer ◽  
Electrical Actuation
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