Influence of Hydrophobic Surface Modification of Chitosan Based Methotrexate (MTX) Micro Implants to Treat Intraocular Lymphoma

2013 ◽  
Author(s):  
Soumyarwit Manna ◽  
James J. Augsburger ◽  
Zelia M. Correa ◽  
Julio A. Landero ◽  
Rupak K. Banerjee
Keyword(s):  
Surface Modification ◽  
Sustained Release ◽  
Hydrophobic Surface ◽  
Intraocular Lymphoma ◽  
Therapeutic Dosage ◽  
Primary Intraocular Lymphoma ◽  
Rare Form ◽  
Chemotherapeutic Effect ◽  
Oncology Practice ◽  
Micro Implants

Primary intraocular lymphoma (PIOL) is a rare form of lymphoma which is encountered in ocular oncology practice. Most preferred treatment has been intravitreal MTX injections which do not have a long lasting chemotherapeutic effect due to rapid elimination of the drug. In this study, chitosan (CS) and polylactic acid (PLA) based intraocular implants are fabricated for different MTX loadings (10%, 25% and 40% w/w). The implants administer a therapeutic dosage of 0.2–2.0 μg/day of MTX over a period of a month. PLA coated CS-MTX implants can be used for sustained release of MTX, thereby improving the treatment of PIOL.

Development of Chitosan and Polylactic Acid Based Methotrexate Intravitreal Micro-Implants to Treat Primary Intraocular Lymphoma: An In Vitro Study

2014 ◽  
Vol 136 (2) ◽  
Author(s):  
Soumyarwit Manna ◽  
James J. Augsburger ◽  
Zelia M. Correa ◽  
Julio A. Landero ◽  
Rupak K. Banerjee
Keyword(s):  
Drug Release ◽  
Polylactic Acid ◽  
Model Fit ◽  
External Beam Radiation ◽  
Intraocular Lymphoma ◽  
Therapeutic Window ◽  
Burst Release ◽  
Primary Intraocular Lymphoma ◽  
Beam Radiation ◽  
Micro Implants

Primary intraocular lymphoma (PIOL) is an uncommon but clinically and pathologically distinct form of non-Hodgkin's lymphoma. It provides a therapeutic challenge because of its diverse clinical presentations and variable clinical course. Currently available treatments for PIOL include intravenous multiple drug chemotherapy, external beam radiation therapy, and intravitreal methotrexate (MTX) injection. Each intravitreal injection of MTX is associated with potentially toxic peaks and subtherapeutic troughs of intraocular MTX concentration. Repetitive injections are required to maintain therapeutic levels of MTX in the eye. A sustained release drug delivery system is desired for optimized therapeutic release (0.2–2.0 μg/day) of MTX for over a period of 1 month to achieve effective treatment of PIOL. This study reports development of a unique intravitreal micro-implant, which administers therapeutic release of MTX over a period of 1 month. Chitosan (CS) and polylactic acid (PLA) based micro-implants are fabricated for different MTX loadings (10%, 25%, and 40% w/w). First, CS and MTX mixtures are prepared for different drug loadings, and lyophilized in Tygon® tubing to obtain CS-MTX fibers. The fibers are then cut into desired micro-implant lengths and dip coated in PLA for a hydrophobic surface coating. The micro-implant is characterized using optical microscopy, scanning electron microscopy (SEM), time of flight-secondary ion mass spectroscopy (ToF-SIMS), and differential scanning calorimetry (DSC) techniques. The release rate studies are carried out using a UV-visible spectrophotometer. The total release durations for 10%, 25%, and 40% w/w uncoated CS-MTX micro-implants are only 19, 29, and 32 h, respectively. However, the therapeutic release durations for 10%, 25%, and 40% w/w PLA coated CS-MTX micro-implants significantly improved to 58, 74, and 66 days, respectively. Thus, the PLA coated CS-MTX micro-implants are able to administer therapeutic release of MTX for more than 50 days. The release kinetics of MTX from the coated micro-implants is explained by (a) the Korsmeyer–Peppas and zero order model fit (R2 ∼ 0.9) of the first 60% of the drug release, which indicates the swelling of polymer and initial burst release of the drug; and (b) the first order and Higuchi model fit (R2 ∼ 0.9) from the tenth day to the end of drug release, implying MTX release in the therapeutic window depends on its concentration and follows diffusion kinetics. The PLA coated CS-MTX micro-implants are able to administer therapeutic release of MTX for a period of more than 1 month. The proposed methodology could be used for improved treatment of PIOL.

Immobilization of tannery industrial sludge in ceramic membrane preparation and hydrophobic surface modification for application in atrazine remediation from water

2019 ◽  
Vol 39 (10) ◽  
pp. 3235-3246 ◽  
Author(s):  
Debarati Mukherjee ◽  
Susmita Kar ◽  
Arkaprava Mandal ◽  
Sourja Ghosh ◽  
Swachchha Majumdar
Keyword(s):  
Surface Modification ◽  
Ceramic Membrane ◽  
Hydrophobic Surface ◽  
Membrane Preparation ◽  
Industrial Sludge

Iris Involvement in Primary Intraocular Lymphoma

2000 ◽  
Vol 44 (6) ◽  
pp. 518-526 ◽  
Author(s):  
Gisela Velez ◽  
Marc D de Smet ◽  
Scott M Whitcup ◽  
Michael Robinson ◽  
Robert B Nussenblatt ◽  
...  
Keyword(s):  
Intraocular Lymphoma ◽  
Primary Intraocular Lymphoma

OCULAR SARCOIDOSIS MISDIAGNOSED AS PRIMARY INTRAOCULAR LYMPHOMA

Retina ◽  
2010 ◽  
Vol 30 (2) ◽  
pp. 310-316 ◽  
Author(s):  
ANDREA D. BIRNBAUM ◽  
WENDY HUANG ◽  
OZLEM SAHIN ◽  
HOWARD H. TESSLER ◽  
DEBRA A. GOLDSTEIN
Keyword(s):  
Intraocular Lymphoma ◽  
Primary Intraocular Lymphoma ◽  
Ocular Sarcoidosis

Hydrophobic surface modification of FMSS and its application as effective sorbents for oil spill clean‐ups and recovery

AIChE Journal ◽  
2017 ◽  
Vol 63 (9) ◽  
pp. 4090-4102 ◽  
Author(s):  
Oluwasola Oribayo ◽  
Qinmin Pan ◽  
Xianshe Feng ◽  
Garry L. Rempel
Keyword(s):  
Surface Modification ◽  
Oil Spill ◽  
Hydrophobic Surface

Use of silicone quaternary ammonium salt for hydrophobic surface modification to inhibit shale hydration and mechanism study

2021 ◽  
Vol 341 ◽  
pp. 117369
Author(s):  
Xianbin Huang ◽  
Jinsheng Sun ◽  
Jiafeng Jin ◽  
Kaihe Lv ◽  
Haichao Li ◽  
...  
Keyword(s):  
Surface Modification ◽  
Ammonium Salt ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salt ◽  
Hydrophobic Surface ◽  
Mechanism Study

Hydrophilic/hydrophobic surface modification impact on colloid lithography: Schottky-like defects, dislocation, and ideal distribution

2018 ◽  
Vol 433 ◽  
pp. 443-448 ◽  
Author(s):  
Vasilii Burtsev ◽  
Valentina Marchuk ◽  
Artem Kugaevskiy ◽  
Olga Guselnikova ◽  
Roman Elashnikov ◽  
...  
Keyword(s):  
Surface Modification ◽  
Hydrophobic Surface

Su.127. Eradication of Tumor Colonization and Invasion By a B-Cell Specific Immunotoxin in a Murine Model for Human Primary Intraocular Lymphoma (Piol)

2006 ◽  
Vol 119 ◽  
pp. S203
Author(s):  
Zhuqing Li ◽  
Mahesh Sankaranarayana ◽  
Baoying Liu ◽  
Chi-Chao Chan ◽  
DeFeng Shen ◽  
...  
Keyword(s):  
B Cell ◽  
Murine Model ◽  
Intraocular Lymphoma ◽  
Primary Intraocular Lymphoma

One-step bonding and hydrophobic surface modification method for rapid fabrication of polycarbonate-based droplet microfluidic chips

2019 ◽  
Vol 282 ◽  
pp. 60-68 ◽  
Author(s):  
Shisheng Su ◽  
Gaoshan Jing ◽  
Miaoqi Zhang ◽  
Baoxia Liu ◽  
Xiurui Zhu ◽  
...  
Keyword(s):  
Surface Modification ◽  
Hydrophobic Surface ◽  
Microfluidic Chips ◽  
Rapid Fabrication ◽  
Modification Method ◽  
One Step
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