Breast cancer mitosis detection in histopathological images with spatial feature extraction

2013 ◽  
Author(s):  
Abdülkadir Albayrak ◽  
Gökhan Bilgin
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Anabia Sohail ◽  
Asifullah Khan ◽  
Noorul Wahab ◽  
Aneela Zameer ◽  
Saranjam Khan

AbstractThe mitotic activity index is a key prognostic measure in tumour grading. Microscopy based detection of mitotic nuclei is a significant overhead and necessitates automation. This work proposes deep CNN based multi-phase mitosis detection framework “MP-MitDet” for mitotic nuclei identification in breast cancer histopathological images. The workflow constitutes: (1) label-refiner, (2) tissue-level mitotic region selection, (3) blob analysis, and (4) cell-level refinement. We developed an automatic label-refiner to represent weak labels with semi-sematic information for training of deep CNNs. A deep instance-based detection and segmentation model is used to explore probable mitotic regions on tissue patches. More probable regions are screened based on blob area and then analysed at cell-level by developing a custom CNN classifier “MitosRes-CNN” to filter false mitoses. The performance of the proposed “MitosRes-CNN” is compared with the state-of-the-art CNNs that are adapted to cell-level discrimination through cross-domain transfer learning and by adding task-specific layers. The performance of the proposed framework shows good discrimination ability in terms of F-score (0.75), recall (0.76), precision (0.71) and area under the precision-recall curve (0.78) on challenging TUPAC16 dataset. Promising results suggest good generalization of the proposed framework that can learn characteristic features from heterogenous mitotic nuclei.


Author(s):  
Inzamam Mashood Nasir ◽  
Muhammad Rashid ◽  
Jamal Hussain Shah ◽  
Muhammad Sharif ◽  
Muhammad Yahiya Haider Awan ◽  
...  

Background: Breast cancer is considered as the most perilous sickness among females worldwide and the ratio of new cases is expanding yearly. Many researchers have proposed efficient algorithms to diagnose breast cancer at early stages, which have increased the efficiency and performance by utilizing the learned features of gold standard histopathological images. Objective: Most of these systems have either used traditional handcrafted features or deep features which had a lot of noise and redundancy, which ultimately decrease the performance of the system. Methods: A hybrid approach is proposed by fusing and optimizing the properties of handcrafted and deep features to classify the breast cancer images. HOG and LBP features are serially fused with pretrained models VGG19 and InceptionV3. PCR and ICR are used to evaluate the classification performance of proposed method. Results: The method concentrates on histopathological images to classify the breast cancer. The performance is compared with state-of-the-art techniques, where an overall patient-level accuracy of 97.2% and image-level accuracy of 96.7% is recorded. Conclusion: The proposed hybrid method achieves the best performance as compared to previous methods and it can be used for the intelligent healthcare systems and early breast cancer detection.


2020 ◽  
Vol 14 ◽  
Author(s):  
Lahari Tipirneni ◽  
Rizwan Patan

Abstract:: Millions of deaths all over the world are caused by breast cancer every year. It has become the most common type of cancer in women. Early detection will help in better prognosis and increases the chance of survival. Automating the classification using Computer-Aided Diagnosis (CAD) systems can make the diagnosis less prone to errors. Multi class classification and Binary classification of breast cancer is a challenging problem. Convolutional neural network architectures extract specific feature descriptors from images, which cannot represent different types of breast cancer. This leads to false positives in classification, which is undesirable in disease diagnosis. The current paper presents an ensemble Convolutional neural network for multi class classification and Binary classification of breast cancer. The feature descriptors from each network are combined to produce the final classification. In this paper, histopathological images are taken from publicly available BreakHis dataset and classified between 8 classes. The proposed ensemble model can perform better when compared to the methods proposed in the literature. The results showed that the proposed model could be a viable approach for breast cancer classification.


2021 ◽  
pp. 0309524X2199826
Author(s):  
Guowei Cai ◽  
Yuqing Yang ◽  
Chao Pan ◽  
Dian Wang ◽  
Fengjiao Yu ◽  
...  

Multi-step real-time prediction based on the spatial correlation of wind speed is a research hotspot for large-scale wind power grid integration, and this paper proposes a multi-location multi-step wind speed combination prediction method based on the spatial correlation of wind speed. The correlation coefficients were determined by gray relational analysis for each turbine in the wind farm. Based on this, timing-control spatial association optimization is used for optimization and scheduling, obtaining spatial information on the typical turbine and its neighborhood information. This spatial information is reconstructed to improve the efficiency of spatial feature extraction. The reconstructed spatio-temporal information is input into a convolutional neural network with memory cells. Spatial feature extraction and multi-step real-time prediction are carried out, avoiding the problem of missing information affecting prediction accuracy. The method is innovative in terms of both efficiency and accuracy, and the prediction accuracy and generalization ability of the proposed method is verified by predicting wind speed and wind power for different wind farms.


2020 ◽  
Vol 13 (1) ◽  
pp. 9
Author(s):  
Fanqiang Kong ◽  
Kedi Hu ◽  
Yunsong Li ◽  
Dan Li ◽  
Shunmin Zhao

Recently, the rapid development of multispectral imaging technology has received great attention from many fields, which inevitably involves the image transmission and storage problem. To solve this issue, a novel end-to-end multispectral image compression method based on spectral–spatial feature partitioned extraction is proposed. The whole multispectral image compression framework is based on a convolutional neural network (CNN), whose innovation lies in the feature extraction module that is divided into two parallel parts, one is for spectral and the other is for spatial. Firstly, the spectral feature extraction module is used to extract spectral features independently, and the spatial feature extraction module is operated to obtain the separated spatial features. After feature extraction, the spectral and spatial features are fused element-by-element, followed by downsampling, which can reduce the size of the feature maps. Then, the data are converted to bit-stream through quantization and lossless entropy encoding. To make the data more compact, a rate-distortion optimizer is added to the network. The decoder is a relatively inverse process of the encoder. For comparison, the proposed method is tested along with JPEG2000, 3D-SPIHT and ResConv, another CNN-based algorithm on datasets from Landsat-8 and WorldView-3 satellites. The result shows the proposed algorithm outperforms other methods at the same bit rate.


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