Research on fast and accurate acquisition method of decay time constant

2021 ◽  
Author(s):  
yucheng ouyang ◽  
bin zhang ◽  
yuchuan quan ◽  
zhongqi tan
Keyword(s):  
Time Constant ◽  
Decay Time ◽  
Decay Time Constant ◽  
Acquisition Method

scholarly journals Measurement of Decay Time Constant of Shielding Current in ITER-TF Joint Samples

2021 ◽  
Vol 1857 (1) ◽  
pp. 012013
Author(s):  
S Imagawa ◽  
H Kajitani ◽  
T Obana ◽  
S Takada ◽  
S Hamaguchi ◽  
...  
Keyword(s):  
Time Constant ◽  
Decay Time ◽  
Decay Time Constant

scholarly journals Fast, Slow, and Steady-State Effects of Contralateral Acoustic Activation of the Medial Olivocochlear Efferent System in Awake Guinea Pigs: Action of Gentamicin

1997 ◽  
Vol 78 (4) ◽  
pp. 1826-1836 ◽  
Author(s):  
Deise Lima da Costa ◽  
Anne Chibois ◽  
Jean-Paul Erre ◽  
Christophe Blanchet ◽  
RENAUD CHARLET de Sauvage ◽  
...  
Keyword(s):  
Steady State ◽  
Time Constant ◽  
Decay Time ◽  
Guinea Pigs ◽  
Round Window ◽  
Broadband Noise ◽  
Decay Time Constant ◽  
Efferent System ◽  
Medial Olivocochlear ◽  
Medial Olivocochlear Efferent System

Lima da Costa, Deise, Anne Chibois, Jean-Paul Erre, Christophe Blanchet, Renaud Charlet de Sauvage, and Jean-Marie Aran. Fast, slow, and steady-state effects of contralateral acoustic activation of the medial olivocochlear efferent system in awake guinea pigs: action of gentamicin. J. Neurophysiol. 78: 1826–1836, 1997. The function of the medial olivocochlear efferent system was observed in awake guinea pigs by recording, in the absence of ipsilateral external acoustic stimulation, the ensemble background activity (EBA) of the VIIIth nerve from an electrode chronically implanted on the round window of one ear. The EBA was measured by calculating the power value of the round window signal in the 0.5- to 2.5-kHz band after digital or analog (active) filtering. This EBA was compared with and without the addition of a low-level broadband noise to the opposite ear. The contralateral broadband noise (CLBN, 55 dB SPL) induced, via the efferent system, a decrease (suppression) of this EBA. With the use of noise bursts of different durations, two components in this suppression could be observed. After the onset of a 1-s CLBN, the power value of the EBA decreased rapidly by 38.0 ± 4.2% (mean ± SD, n = 3), with a latency of <10 ms and a decay time constant of 13.1 ± 1.0 ms (fast effect). At the offset of the 1-s CLBN, EBA came back to prestimulation values with a similar latency and a time constant of 15.5 ± 2.9 ms. During longer CLBN stimulation (≥1 min), EBA presented, after the fast decrease, an additional, slower decrease of 15.6 ± 3.1%, with a delay of 9.8 ± 1.3 s and a decay time constant of 16.1 ± 5.0 s ( n = 12, slow effect), and then remained remarkably constant for as long as observed, i.e., >2 h (steady state). The average global suppression was thus up to 47.8 ± 5.8% of the basal, pre-CLBN-stimulation EBA value. At the offset of the CLBN, EBA returned to pre-CLBN level with fast and slow phases, with, for the slow phase, no delay and a time constant of 32.1 ± 8.1 s. Fast and slow changes in EBA power values were observed after a single injection of gentamicin (GM) at different doses (150, 200, and 250 mg/kg). At 150 and 200 mg/kg, GM progressively and reversibly blocked the rapid effect, but the slow component of the efferent medial suppression remained remarkably unchanged. However, at higher doses both the fast and slow suppressions were totally yet still reversibly blocked. These observations indicate that the medial olivocochlear efferent system exerts sustained influences on outer hair cells and that this effect develops in two different steps that may have different basic cellular mechanisms.

Properties of spontaneous inhibitory synaptic currents in cultured rat spinal cord and medullary neurons

1996 ◽  
Vol 76 (1) ◽  
pp. 448-460 ◽  
Author(s):  
C. A. Lewis ◽  
D. S. Faber
Keyword(s):  
Spinal Cord ◽  
Time Constant ◽  
Decay Time ◽  
Cultured Cells ◽  
Decay Time Constant ◽  
Inhibitory Synapses ◽  
Gamma Aminobutyric Acid ◽  
Postsynaptic Receptor ◽  
Decay Times ◽  
Medullary Neurons

1. To identify the type(s) and properties of inhibitory postsynaptic receptor(s) involved in synaptic transmission in cultured rat embryonic spinal cord and medullary neurons, we have used whole cell patch-clamp techniques to record miniature inhibitory postsynaptic currents (mIPSCs) in the presence of tetrodotoxin, DL-2-amino-5-phosphonovaleric acid, and 6-cyano-7-nitroquinoxaline-2,3-dione. 2. The mIPSCs recorded from both spinal cord and medullary neurons had skewed amplitude distributions. 3. The glycinergic antagonist strychnine and the GABAergic antagonist bicuculline each decreased both the frequency and mean peak amplitudes of mIPSCs. We conclude that both glycine and gamma-aminobutyric acid (GABA) are neurotransmitters at inhibitory synapses in our cultured cells. 4. Most (approximately 96-97%) mIPSCs decay with single-exponential time constants, and decay time distributions were consistently best fitted by the sum of four Gaussians with decay constants as follows: D1 = 5.8 +/- 0.1 (SE) ms (n = 63), D2 = 12.2 +/- 0.2 ms (n = 61), D3 = 23.2 +/- 0.4 ms (n = 54), and D4 = 44.7 +/- 1.0 ms (n = 57). We conclude that the four classes of decay times represent kinetically different inhibitory postsynaptic receptor populations. 5. Strychnine and bicuculline usually had one of two different effects on the mIPSC decay time constant distributions; either selective decreases in the frequency of mIPSCs with decay times in certain classes (i.e., the D1 class was reduced by bicuculline, the D2 class by strychnine, and the D3 and D4 classes by both antagonists) or a nonselective depression in the frequency of mIPSCs with decay times in all four classes. The particular effect observed in a given neuron was correlated with the presence or absence of ATP and guanosine 5'-triphosphate (GTP) in the patch pipette. Namely, in 71% of the antagonist applications where the pipette contained ATP and GTP, the result was a nonselective decrease in mIPSCs in all decay time constant classes. Conversely, in 54% of the antagonist applications in their absence, the result was a selective decrease in the frequency of mIPSCs in specific decay time constant classes. 6. In some experiments, mIPSCs reappeared in antagonist solution after an essentially complete block. Recovery from block in the continued presence of antagonist was never observed in the absence of ATP and GTP (8 neurons), and, at the same time, 5 of 9 neurons patched with ATP and GTP in the pipette did show recovery (56%).

Effects of the GABA uptake inhibitor tiagabine on inhibitory synaptic potentials in rat hippocampal slice cultures

1992 ◽  
Vol 67 (6) ◽  
pp. 1698-1701 ◽  
Author(s):  
S. M. Thompson ◽  
B. H. Gahwiler
Keyword(s):  
Time Constant ◽  
Decay Time ◽  
Time Course ◽  
Hippocampal Slice ◽  
Decay Time Constant ◽  
Gabab Receptors ◽  
Gaba Uptake ◽  
Whole Cell ◽  
Synaptic Potentials ◽  
Hippocampal Slice Cultures

1. The effects of the gamma-aminobutyric acid (GABA) uptake blocker tiagabine on inhibitory synaptic potentials (IPSPs) were examined with microelectrode and whole-cell recording from CA3 pyramidal cells in rat hippocampal slice cultures. 2. Tiagabine (10-25 microM) greatly prolonged the duration of monosynaptic IPSPs elicited in the presence of excitatory amino acid antagonists but had no effect on their amplitude. Part of the prolonged time course resulted from a GABAB receptor-mediated component that was not detectable under control conditions. 3. The mean decay time constant of the underlying GABAA receptor-mediated synaptic current was increased from 16 to 250 ms. Spontaneous miniature IPSPs recorded with whole-cell clamp were unaffected by tiagabine. Pentobarbital sodium, in contrast, increased the decay time constant of both evoked and spontaneous GABAA-mediated currents. 4. Tiagabine (25 microM) inhibited spontaneous and evoked epileptiform bursting induced by increasing the extracellular potassium concentration to 8 mM. 5. We conclude that GABA uptake plays a significant role in determining the time course of evoked IPSPs and also limits the likelihood that GABAB receptors are activated.

scholarly journals Enhanced Temporal Stability of Cholinergic Hippocampal Gamma Oscillations Following Respiratory Alkalosis In Vitro

2001 ◽  
Vol 85 (5) ◽  
pp. 2063-2069 ◽  
Author(s):  
Kerstin Stenkamp ◽  
J. Matias Palva ◽  
Marylka Uusisaari ◽  
Sebastian Schuchmann ◽  
Dietmar Schmitz ◽  
...  
Keyword(s):  
Time Constant ◽  
Decay Time ◽  
Oscillation Frequency ◽  
Hippocampal Slices ◽  
Temporal Stability ◽  
Field Potential ◽  
Gamma Oscillations ◽  
Decay Time Constant ◽  
The Mean

The decrease in brain CO2 partial pressure (pCO2) that takes place both during voluntary and during pathological hyperventilation is known to induce gross alterations in cortical functions that lead to subjective sensations and altered states of consciousness. The mechanisms that mediate the effects of the decrease in pCO2 at the neuronal network level are largely unexplored. In the present work, the modulation of gamma oscillations by hypocapnia was studied in rat hippocampal slices. Field potential oscillations were induced by the cholinergic agonist carbachol under an N-methyl-D-aspartate (NMDA)-receptor blockade and were recorded in the dendritic layer of the CA3 region with parallel measurements of changes in interstitial and intraneuronal pH (pHo and pHi, respectively). Hypocapnia from 5 to 1% CO2 led to a stable monophasic increase of 0.5 and 0.2 units in pHo and pHi, respectively. The mean oscillation frequency increased slightly but significantly from 32 to 34 Hz and the mean gamma-band amplitude (20 to 80 Hz) decreased by 20%. Hypocapnia induced a dramatic enhancement of the temporal stability of the oscillations, as was indicated by a two-fold increase in the exponential decay time constant fitted to the autocorrelogram. A rise in pHi evoked by the weak base trimethylamine (TriMA) was associated with a slight increase in oscillation frequency (37 to 39 Hz) and a decrease in amplitude (30%). Temporal stability, on the other hand, was decreased by TriMA, which suggests that its enhancement in 1% CO2 was related to the rise in pHo. In 1% CO2, the decay-time constant of the evoked monosynaptic pyramidal inhibitory postsynaptic current (IPSC) was unaltered but its amplitude was enhanced. This increase in IPSC amplitude seems to significantly contribute to the enhancement of temporal stability because the enhancement was almost fully reversed by a low concentration of bicuculline. These results suggest that changes in brain pCO2 can have a strong influence on the temporal modulation of gamma rhythms.

Reduction of Zolpidem Sensitivity in a Freeze Lesion Model of Neocortical Dysgenesis

1999 ◽  
Vol 81 (1) ◽  
pp. 404-407 ◽  
Author(s):  
R. Anthony Defazio ◽  
John J. Hablitz
Keyword(s):  
Time Constant ◽  
Decay Time ◽  
Brain Slices ◽  
Pyramidal Cells ◽  
Benzodiazepine Receptor ◽  
Decay Time Constant ◽  
Α Subunit ◽  
Rat Neocortex

DeFazio, R. Anthony and John J. Hablitz. Reduction of zolpidem sensitivity in a freeze lesion model of neocortical dysgenesis. J. Neurophysiol. 81: 404–407, 1999. Early postnatal freeze lesions in rat neocortex produce anatomic abnormalities resembling those observed in human patients with seizure disorders. Although in vitro brain slices containing the lesion are hyperexcitable, the mechanisms of this alteration have yet to be elucidated. To test the hypothesis that changes in postsynaptic inhibitory receptors may underlie this hyperexcitability, we examined properties of γ-aminobutyric acid type A receptor (GABAAR)–mediated miniature inhibitory postsynaptic currents (mIPSCs). Recordings were obtained in layer II/III pyramidal cells located 1–2 mm lateral to the lesion. mIPSC peak amplitude and rate of rise were increased relative to nonlesioned animals, whereas decay time constant and interevent interval were unaltered. Bath application of zolpidem at a concentration (20 nM) specific for activation of the type 1 benzodiazepine receptor had no significant effect on decay time constant in six of nine cells. Exposure to higher concentrations (100 nM) enhanced the decay time constant of all cells tested ( n = 7). Because mIPSCs from unlesioned animals were sensitive to both concentrations of zolpidem, these results suggest that freeze lesions may decrease the affinity of pyramidal cell GABAARs for zolpidem. This could be mediated via a change in α-subunit composition of the GABAAR, which eliminates the type 1 benzodiazepine receptor.

scholarly journals Multimodal Non-Contact Luminescence Thermometry with Cr-Doped Oxides

Sensors ◽  
2020 ◽  
Vol 20 (18) ◽  
pp. 5259
Author(s):  
Vitaliy Mykhaylyk ◽  
Hans Kraus ◽  
Yaroslav Zhydachevskyy ◽  
Volodymyr Tsiumra ◽  
Andriy Luchechko ◽  
...  
Keyword(s):  
Time Constant ◽  
Decay Time ◽  
Intensity Ratio ◽  
Decay Time Constant ◽  
Wavelength Shift ◽  
Thermally Induced ◽  
Multimodal Sensing ◽  
Scintillation Decay Time ◽  
Induced Changes ◽  
Contact Measurements

Luminescence methods for non-contact temperature monitoring have evolved through improvements of hardware and sensor materials. Future advances in this field rely on the development of multimodal sensing capabilities of temperature probes and extend the temperature range across which they operate. The family of Cr-doped oxides appears particularly promising and we review their luminescence characteristics in light of their application in non-contact measurements of temperature over the 5–300 K range. Multimodal sensing utilizes the intensity ratio of emission lines, their wavelength shift, and the scintillation decay time constant. We carried out systematic studies of the temperature-induced changes in the luminescence of the Cr3+-doped oxides Al2O3, Ga2O3, Y3Al5O12, and YAlO3. The mechanism responsible for the temperature-dependent luminescence characteristic is discussed in terms of relevant models. It is shown that the thermally-induced processes of particle exchange, governing the dynamics of Cr3+ ion excited state populations, require low activation energy. This then translates into tangible changes of a luminescence parameter with temperature. We compare different schemes of temperature sensing and demonstrate that Ga2O3-Cr is a promising material for non-contact measurements at cryogenic temperatures. A temperature resolution better than ±1 K can be achieved by monitoring the luminescence intensity ratio (40–140 K) and decay time constant (80–300 K range).

The Thermal Neutron Decay Time Log

1970 ◽  
Vol 10 (04) ◽  
pp. 365-379 ◽  
Author(s):  
J.S. Wahl ◽  
W.B. Nelligan ◽  
A.H. Frentrop ◽  
C.W. Johnstone ◽  
R.J. Schwartz
Keyword(s):  
Thermal Neutron ◽  
Time Constant ◽  
Decay Time ◽  
High Energy ◽  
Decay Time Constant ◽  
Neutron Decay ◽  
Fast Neutrons ◽  
Neutron Density ◽  
Thermal Neutrons ◽  
Open Hole

Abstract Thermal Neutron Decay Time (TDT) logging tools in 3-3/8 and 1-11/16-in. diameters have been developed for detection and evaluation of water saturation in cased holes. These tools utilize a system of movable and expandable detection time-gates which are automatically adjusted as the log is being run. The two principal detection gates are positioned in time after the neutron burst according to an optimization criterion. An additional gate, delayed until most of the decay has taken place, permits correction for background. This place, permits correction for background. This Scale Factor gating method provides, in each bed, a thermal-decay-time measurement of maximum statistical precision consistent with removal of borehole effects present in the early part of the decay period Increased reliability is afforded by use of digital techniques. Thermal neutron decay time tools employ capture-gamma-ray detection. This choice was based on an extensive series of experiments made to compare gamma-ray detection and direct detection of thermal neutrons. Measurements of thermal neutron decay time constant are affected by local changes in neutron density in the vicinity of the sonde, caused by flow of neutrons by diffusion from one medium to another. The measured decay time constant (T meas) of neutron density at any point may differ, therefore, from the intrinsic decay time constant (T int) produced by absorption alone. The basic physics of neutron diffusion and absorption is reviewed. When the borehole and the formation have different decay time constants and diffusion coefficients, diffusion couples the two regions. Consideration of such effects sheds light on the conditions required for reduction of borehole effects on measured values of the decay time constant. The choice of source-detector spacing is affected. and, for accurate quantitative interpretation, departure curves are required. Departure curves are presented showing the effects of varying cement thickness, casing diameter. and casing fluids Illustrative log examples are shown. Introduction The Thermal Neutron Decay Time (TDT) log provides a determination of the time constant for provides a determination of the time constant for the decay of thermal neutrons in the formation. Hence, it reflects primarily the neutron absorptive properties of the formation. These properties are properties of the formation. These properties are useful in formation evaluation. The most important area of application is in logging cased hole. Because chlorine is by far the strongest thermal neutron absorber of the common earth elements, the TDT log responds largely to the amount of NaCl present in the formation water. As a result, this present in the formation water. As a result, this log resembles the usual open-hole resistivity logs and is easily correlatable with them. When information on lithology and porosity is known or is provided by open-hole logs, a log of neutron provided by open-hole logs, a log of neutron absorption properties permits the solution of a wide variety of problems: saturation determination, oil-water contact location, detection of gas behind casing, etc. Measurements of the thermal neutron decay time constant are made by first irradiating the formation with a pulse of high-energy neutrons from a neutron generator in the sonde, and then, a short time after the neutron source is turned off, determining the rate at which the thermal neutron population decreases. After each neutron burst, the high-energy neutrons are quickly slowed down to thermal velocities by successive collisions with the nuclei of elements in the formation and borehole. The relative number of thermal neutrons remaining in the formation is measured during detection intervals which follow each burst. Between each burst and the beginning of the first detection interval is a delay time which permits the originally fast neutrons to reach thermal permits the originally fast neutrons to reach thermal energy and allows "early" borehole effects to subside. SPEJ p. 365

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