Merging microsecond mixing and time-correlated single-photon counting: using time-resolved FRET and time-resolved anisotropy to probe early events in protein folding

2007 ◽  
Author(s):  
Osman Bilsel ◽  
Ying Wu ◽  
Can Kayatekin ◽  
C. Robert Matthews
Keyword(s):  
Protein Folding ◽  
Single Photon ◽  
Photon Counting ◽  
Time Resolved ◽  
Single Photon Counting

Single Point PICA Probing with an Avalanche Photo-Diode

2001 ◽  
Author(s):  
Mike Bruce ◽  
Rama R. Goruganthu ◽  
Shawn McBride ◽  
David Bethke ◽  
J.M. Chin
Keyword(s):  
Single Photon ◽  
Single Point ◽  
Photon Counting ◽  
Ring Oscillator ◽  
Time Resolved ◽  
Single Photon Counting ◽  
Photo Diode ◽  
Avalanche Photo Diode ◽  
Photo Multiplier Tube ◽  
Channel Plate

Abstract For time resolved hot carrier emission from the backside, an alternate approach is demonstrated termed single point PICA. The single point approach records time resolved emission from an individual transistor using time-correlated-single-photon counting and an avalanche photo-diode. The avalanche photo-diode has a much higher quantum efficiency than micro-channel plate photo-multiplier tube based imaging cameras typically used in earlier approaches. The basic system is described and demonstrated from the backside on a ring oscillator circuit.

Compact, Low-Power and Fully Reconfigurable 10 ps Resolution, 160 Range, Time-Resolved Single-Photon Counting System

2016 ◽  
Vol 16 (10) ◽  
pp. 3827-3833 ◽  
Author(s):  
Davide Tamborini ◽  
Mauro Buttafava ◽  
Alessandro Ruggeri ◽  
Franco Zappa
Keyword(s):  
Low Power ◽  
Single Photon ◽  
Photon Counting ◽  
Counting System ◽  
Time Resolved ◽  
Single Photon Counting

scholarly journals A space- and time-resolved single photon counting detector for fluorescence microscopy and spectroscopy

2006 ◽  
Author(s):  
X. Michalet ◽  
O.H.W. Siegmund ◽  
J. V. Vallerga ◽  
P. Jelinsky ◽  
J. E. Millaud ◽  
...  
Keyword(s):  
Fluorescence Microscopy ◽  
Single Photon ◽  
Photon Counting ◽  
Time Resolved ◽  
Single Photon Counting ◽  
Photon Counting Detector ◽  
Space And Time

scholarly journals Pseudo-random single photon counting for time-resolved optical measurement

2008 ◽  
Vol 16 (17) ◽  
pp. 13233 ◽  
Author(s):  
Qiang Zhang ◽  
Hock Wei Soon ◽  
Haiting Tian ◽  
Shakith Fernando ◽  
Yajun Ha ◽  
...  
Keyword(s):  
Optical Measurement ◽  
Single Photon ◽  
Photon Counting ◽  
Time Resolved ◽  
Single Photon Counting

scholarly journals A pilot study of the dynamics of tissue oxygenation in vivo using time-resolved phosphorescence imaging

2021 ◽  
pp. 2142001
Author(s):  
Natalia Kazachkina ◽  
Julia Lymar ◽  
Vladislav Shcheslavskiy ◽  
Alexander Savitsky
Keyword(s):  
Solid Tumor ◽  
Single Photon ◽  
Photon Counting ◽  
Time Resolved ◽  
Phosphorescence Lifetime ◽  
Phosphorescence Quenching ◽  
Single Photon Counting ◽  
Normal Tissues ◽  
Phosphorescence Lifetime Imaging

Oxygenation of tissues plays an important role in the development and progression of tumor to treatment effects. Method of metalloporphyrines phosphorescence quenching by oxygen is one of the ways to measure dynamics of the oxygen concentration in the tissues by phosphorescence lifetime imaging of meso-tetra(sulfopheny1)tetrabenzoporphyrin Pd (II) (TBP) using the time-correlated single photon counting (TCSPC) method. It has been shown that phosphorescence lifetime of the sensor in S37 tumor in vivo varied in the range of 130 to 290 [Formula: see text]s after both topical and intravenous administration of TBP. It indicates that oxygen level in tumors was lower compared to normal tissues where TBP phosphorescence has not been detected. Phosphorescence lifetimes of TBP increased in the solid tumor and in the muscle after photodynamic therapy of solid tumor that demonstrates oxygen consumption during treatment and possibly stopping the blood flow and hence the oxygen supply to the tissues.

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