Distinction of gastric cancer tissue based on surface-enhanced Raman spectroscopy

2012 ◽  
Author(s):  
Jun Ma ◽  
Hanjing Zhou ◽  
Longjing Gong ◽  
Shu Liu ◽  
Zhenghua Zhou ◽  
...  
2016 ◽  
Author(s):  
Xiaosong Ge ◽  
Xueliang Lin ◽  
Zhihong Xu ◽  
Guoqiang Wei ◽  
Wei Huang ◽  
...  

2018 ◽  
Vol 26 (18) ◽  
pp. 1102-1110
Author(s):  
Yan-Ling Liu ◽  
Li-Yun Huang ◽  
Hui-Qing Zhong ◽  
Min Lu ◽  
Yu-Qing Hou ◽  
...  

2017 ◽  
Author(s):  
Caitlin S. DeJong ◽  
David I. Wang ◽  
Aleksandr Polyakov ◽  
Anita Rogacs ◽  
Steven J. Simske ◽  
...  

Through the direct detection of bacterial volatile organic compounds (VOCs), via surface enhanced Raman spectroscopy (SERS), we report here a reconfigurable assay for the identification and monitoring of bacteria. We demonstrate differentiation between highly clinically relevant organisms: <i>Escherichia coli</i>, <i>Enterobacter cloacae</i>, and <i>Serratia marcescens</i>. This is the first differentiation of bacteria via SERS of bacterial VOC signatures. The assay also detected as few as 10 CFU/ml of <i>E. coli</i> in under 12 hrs, and detected <i>E. coli</i> from whole human blood and human urine in 16 hrs at clinically relevant concentrations of 10<sup>3</sup> CFU/ml and 10<sup>4</sup> CFU/ml, respectively. In addition, the recent emergence of portable Raman spectrometers uniquely allows SERS to bring VOC detection to point-of-care settings for diagnosing bacterial infections.


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