SU-FF-T-458: Complementing Targeted Radionuclide Therapy with External Beam Radiotherapy: Planning Study

2009 ◽  
Vol 36 (6Part16) ◽  
pp. 2628-2628
Author(s):  
J Grudzinski ◽  
S Bowen ◽  
W Tome ◽  
J Weichert ◽  
R Jeraj
Keyword(s):  
Radionuclide Therapy ◽  
External Beam Radiotherapy ◽  
Radiotherapy Planning ◽  
External Beam ◽  
Targeted Radionuclide Therapy ◽  
Planning Study

scholarly journals Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy

Theranostics ◽  
2021 ◽  
Vol 11 (13) ◽  
pp. 6120-6137
Author(s):  
Justin C. Jagodinsky ◽  
Won Jong Jin ◽  
Amber M. Bates ◽  
Reinier Hernandez ◽  
Joseph J. Grudzinski ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Radionuclide Therapy ◽  
External Beam Radiotherapy ◽  
Temporal Analysis ◽  
External Beam ◽  
Targeted Radionuclide Therapy ◽  
Type 1 Interferon

scholarly journals Safety and feasibility of an in situ vaccination and immunomodulatory targeted radionuclide combination immuno-radiotherapy approach in a comparative (companion dog) setting

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255798
Author(s):  
Kara Magee ◽  
Ian R. Marsh ◽  
Michelle M. Turek ◽  
Joseph Grudzinski ◽  
Eduardo Aluicio-Sarduy ◽  
...  
Keyword(s):  
Radionuclide Therapy ◽  
External Beam Radiotherapy ◽  
Low Grade ◽  
External Beam ◽  
Advanced Stage ◽  
Targeted Radionuclide Therapy ◽  
Safe Delivery ◽  
Companion Dogs ◽  
Subject Specific

Rationale Murine syngeneic tumor models have revealed efficacious systemic antitumor responses following primary tumor in situ vaccination combined with targeted radionuclide therapy to secondary or metastatic tumors. Here we present studies on the safety and feasibility of this approach in a relevant translational companion dog model (n = 17 dogs) with advanced cancer. Methods The three component of the combination immuno-radiotherapy approach were employed either separately or in combination in companion dogs with advanced stage cancer. In situ vaccination was achieved through the administration of hypofractionated external beam radiotherapy and intratumoral hu14.18-IL2 fusion immunocytokine injections to the index tumor. In situ vaccination was subsequently combined with targeted radionuclide therapy using a theranostic pairing of IV 86Y-NM600 (for PET imaging and subject-specific dosimetry) and IV 90Y-NM600 (therapeutic radionuclide) prescribed to deliver an immunomodulatory 2 Gy dose to all metastatic sites in companion dogs with metastatic melanoma or osteosarcoma. In a subset of dogs, immunologic parameters preliminarily assessed. Results The components of the immuno-radiotherapy combination were well tolerated either alone or in combination, resulting in only transient low grade (1 or 2) adverse events with no dose-limiting events observed. In subject-specific dosimetry analyses, we observed 86Y-NM600 tumor:bone marrow absorbed-dose differential uptakes ≥2 in 4 of 5 dogs receiving the combination, which allowed subsequent safe delivery of at least 2 Gy 90Y-NM600 TRT to tumors. NanoString gene expression profiling and immunohistochemistry from pre- and post-treatment biopsy specimens provide evidence of tumor microenvironment immunomodulation by 90Y-NM600 TRT. Conclusions The combination of external beam radiotherapy, intratumoral immunocytokine, and targeted radionuclide immuno-radiotherapy known to have activity against syngeneic melanoma in murine models is feasible and well tolerated in companion dogs with advanced stage, spontaneously arising melanoma or osteosarcoma and has immunomodulatory potential. Further studies evaluating the dose-dependent immunomodulatory effects of this immuno-radiotherapy combination are currently ongoing.

SU-GG-T-585: The Impact of Free Breathing versus Average 4D CT Image Data on External Beam Radiotherapy Planning for Liver Tumors

2010 ◽  
Vol 37 (6Part25) ◽  
pp. 3322-3322
Author(s):  
H Li ◽  
M Delclos ◽  
T Briere ◽  
S Beddar ◽  
P Das ◽  
...  
Keyword(s):  
Liver Tumors ◽  
External Beam Radiotherapy ◽  
Image Data ◽  
Free Breathing ◽  
Radiotherapy Planning ◽  
External Beam ◽  
Ct Image ◽  
4D Ct ◽  
The Impact

scholarly journals A study to evaluate the adequacy of pelvic lymph node coverage in carcinoma cervix patients in Indian population by conventional four field box technique using computerized tomography simulation based pelvic lymph node contouring

2020 ◽  
Vol 8 (4) ◽  
pp. 1491
Author(s):  
Tanmoy Ghosh ◽  
Joydeep Basu
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
External Beam Radiotherapy ◽  
Pelvic Lymph Node ◽  
Radiotherapy Planning ◽  
External Beam ◽  
Bony Landmark ◽  
Carcinoma Cervix ◽  
Simulation Based ◽  
Ct Simulation

Background: Traditionally pelvic External Beam Radiotherapy is delivered with four field box technique in carcinoma cervix patients. The primary aim of this prospective observational study is to determine the adequacy of pelvic lymph nodal coverage by conventional Four Field Box Technique with the help of pelvic lymph node contouring by CT simulation.Methods: Between January 2013 and August 2015 sixty patients with biopsy proven Carcinoma Cervix were enrolled in this study. Of these fifty-three patients were available for final analysis. CT simulation based Pelvic lymph node contouring was done for each patient. Then two External Beam Radiotherapy plans were generated, one contoured based and the other based on bony landmark based Four Field Box Technique. The number of patients whose contoured lymph nodes lies partly outside the field borders of the bony landmark-based plan and also its extent was determined. D90 of various groups of pelvic lymph nodes obtained from both the plans were compared using ‘paired sample t - test’.Results: It was seen that with Four Field Box Technique there is inadequate coverage of common iliac lymph nodes in 34/53 patients. The difference between the mean D90 of common iliac lymph nodes in two sets of plans was found to be statistically significant.Conclusions: Pelvic field planning should be individualized. CT simulation-based radiotherapy planning should be done for each individual patient to adequately cover the nodal microscopic disease.

scholarly journals EANM/SNMMI practice guideline for [18F]FDG PET/CT external beam radiotherapy treatment planning in uterine cervical cancer v1.0

2020 ◽  
Author(s):  
Judit A. Adam ◽  
Annika Loft ◽  
Cyrus Chargari ◽  
Roberto C. Delgado Bolton ◽  
Elisabeth Kidd ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Practice Guideline ◽  
Fdg Pet ◽  
External Beam Radiotherapy ◽  
Relevant Literature ◽  
Uterine Cervical Cancer ◽  
Radiotherapy Planning ◽  
External Beam ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract Purpose The aim of this EANM / SNMMI Practice Guideline with ESTRO endorsement is to provide general information and specific considerations about [18F]FDG PET/CT in advanced uterine cervical cancer for external beam radiotherapy planning with emphasis on staging and target definition, mostly in FIGO stages IB3-IVA and IVB, treated with curative intention. Methods Guidelines from related fields, relevant literature and leading experts have been consulted during the development of this guideline. As this field is rapidly evolving, this guideline cannot be seen as definitive, nor is it a summary of all existing protocols. Local variations should be taken into consideration when applying this guideline. Conclusion The background, common clinical indications, qualifications and responsibilities of personnel, procedure / specifications of the examination, documentation / reporting and equipment specifications, quality control and radiation safety in imaging is discussed with an emphasis on the multidisciplinary approach.

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