scholarly journals An improved internal mammary irradiation technique in radiation treatment of locally advanced breast cancers

2005 ◽  
Vol 6 (1) ◽  
pp. 84-93 ◽  
Author(s):  
Jian-Yue Jin ◽  
Eric E. Klein ◽  
Feng-Ming Kong ◽  
Zuofeng Li
Keyword(s):  
Radiation Treatment ◽  
Locally Advanced ◽  
Advanced Breast ◽  
Breast Cancers ◽  
Internal Mammary

Continuous Arterial Infusion of 5-Fluorouracile in Patients with Advanced Breast Cancer

1967 ◽  
Vol 53 (5) ◽  
pp. 503-514
Author(s):  
Bruno Salvadori ◽  
Leandro Gennari ◽  
Sergio Di Pietro ◽  
Umberto Veronesi
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Subclavian Artery ◽  
Brachial Artery ◽  
Internal Mammary Artery ◽  
Locally Advanced ◽  
Advanced Breast ◽  
Arterial Infusion ◽  
Internal Mammary ◽  
Anatomic Region

Fifteen women with advanced breast cancer underwent chemotherapeutical treatment with continuous arterial infusion of 5-Fluorouracile. The age of the patients ranged from 36 to 68 years; the patient of 36 had been previously ovariectomized. For cancer of internal or central quadrants of the breast, internal mammary artery was incannulated, while for those of the external ones, the tip of the catheter was led into subclavian artery through an arterotomy of brachial artery. In the cases in which the tumor was extended to the whole breast two vessels were incannulated, namely internal mammary and brachial artery. The drug was administered in a dose of 1 g a day, for a period of time ranging from 2 to 8 days, in 1000 ml of dextrose solution. The results of the treatment are the following: regression of more than 50% in 4 cases; regression of less than 50% in 5 cases; in 5 cases poor or no result was obtained. One woman died after one day of treatment from coma cerebralis. In 7 cases complications were observed, mainly spasm and thrombosis of the arteries and flittenular dermatitis; in 2 cases a decrease of WBC down to 3000/cmm was observed. In our experience, this method of chemotherapy seems to be indicated in a limited number of cases in which the tumor, though locally advanced, is still contained within the limits of the anatomic region. It is also indicated in case of local recurrences of tumors previously operated and expecially in carcinomatous mastitis.

scholarly journals Changes in allelic imbalances in locally advanced breast cancers after chemotherapy

2007 ◽  
Vol 97 (8) ◽  
pp. 1157-1164 ◽  
Author(s):  
M Varna ◽  
H Soliman ◽  
J-P Feugeas ◽  
E Turpin ◽  
D Chapelin ◽  
...  
Keyword(s):  
Locally Advanced ◽  
Advanced Breast ◽  
Breast Cancers

scholarly journals Incidence of internal mammary node in locally advanced breast cancer and its correlation with metastatic disease: a retrospective observational study

2019 ◽  
Vol 92 (1103) ◽  
pp. 20190098
Author(s):  
Somesh Singh ◽  
Subhash K Ramani ◽  
Ashita Rastogi ◽  
Meenakshi H Thakur
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Metastatic Disease ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Distant Metastases ◽  
Advanced Breast ◽  
Internal Mammary Nodes ◽  
Imaging Results ◽  
Internal Mammary

Objective: To determine incidence of internal mammary nodes (IMN) at baseline CT of locally advanced breast cancer (LABC) and ascertain prognostic implication. Methods and materials: Retrospective review of all LABC patients from 1 January 2012 through 31 December 2014 was performed after approval from institutional review board. CTs of 182 patients enrolled were reviewed by two radiologists independently, and IMNs were documented based on size, location and relation with location of breast primary. 3-year follow-up was analysed and incidence of metastases was calculated as overall incidence, incidence in patients with and without discernible IMN at baseline imaging. Results are presented as numbers and percentages. Differences in metastases of two groups were compared using χ2 test. 95% CI was calculated and p < 0.05 was considered significant. Results: 77 of 182 had identifiable IMN (42.3% incidence). Majority of identifiable nodes were on ipsilateral side of primary (incidence 90.90%) with higher incidence in patients with upper-outer quadrant tumours (55.9%). Majority were seen in second intercostal space (44.4%). 36 (19.7%) developed distant metastases within 3 years of therapy. Of these, 21 (27.3%) had IMN as compared with 15 (14.3 %) without IMN on baseline imaging. Patients with identifiable IMN on baseline CT had significantly higher incidence of distant metastases (p = 0.0321). Conclusion: Significant number LABC patients have identifiable IMN on baseline imaging with patients showing IMN on baseline CT showing significantly higher rate of metastatic disease following therapy. Advances in knowledge: Many LABC patients have identifiable IMNs on baseline imaging which show higher incidence of subsequent metastatic disease.

Treatment and Outcomes of Women With Large Locally Advanced Breast Cancer

2020 ◽  
pp. 000313482095633
Author(s):  
Christopher W. Mangieri ◽  
Julia Ruffo ◽  
Akiko Chiba ◽  
Marissa Howard-McNatt
Keyword(s):  
Breast Cancer ◽  
Metastatic Cancer ◽  
Locally Advanced Breast Cancer ◽  
Multidisciplinary Treatment ◽  
Locally Advanced ◽  
Radical Mastectomy ◽  
Advanced Breast ◽  
Breast Cancers ◽  
Social Challenges ◽  
Radiation Treatments

Advances in breast cancer research have made breast cancer a treatable disease. However, there is a population of women who present with large, advanced, or sometimes neglected breast cancers who can prove difficult to treat. These women often require multiple modality treatment including chemotherapy, surgery, and radiation. The purpose of our study is to examine the treatment and outcomes on women with large, locally advanced breast cancers (LABCs). We identified 8 individuals who presented with LABCs requiring extensive treatment. Patients with inflammatory or metastatic cancer at the time of presentation were excluded. These patients’ charts were reviewed and analyzed. Patient demographics, hormone receptor status, stage, types of treatment, presence of metastasis, survival, and presence of barriers for seeking treatment sooner were identified. The median age at presentation was 65 years old. The patients were equally African American and Caucasian. All patients presented with T4 or stage 3 tumors involving the skin and/or pectoralis muscle. Half of the patients were found to have triple-negative (estrogen receptor, progesterone receptor, Her-2/neu negative) tumors. 87% of the patients received chemotherapy; 1 refused. All 8 patients, either neoadjuvantly or adjuvantly, underwent a modified radical or radical mastectomy. Skin graft or flap coverage was necessary in half of the patients. Postmastectomy radiation was received in 87% of the patients; 1 patient refused the treatment. Half of the patients developed metastatic disease. Thirty-seven percent of the patients have since died with a median survival of 44 months. Reasons for delay in seeking care were monetary or social barriers. Many of the patients finally sought care via the emergency room due to symptoms they could no longer ignore. Women who present with LABC require complex multidisciplinary treatment consisting of chemotherapy, surgery, and radiation treatments. Many of these patients faced economic and social challenges to accessing care. Better access to care and more prompt connection to breast surgeons are required to assist this patient population.

Hypermethylation analysis of mismatch repair genes (hmlh1 and hmsh2) in locally advanced breast cancers in Indian women

2008 ◽  
Vol 39 (5) ◽  
pp. 672-680 ◽  
Author(s):  
Raza Ali Naqvi ◽  
Arif Hussain ◽  
Suryanarayan S.V. Deo ◽  
Himani Kukreti ◽  
Madhur Chauhan ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Locally Advanced ◽  
Advanced Breast ◽  
Mismatch Repair Genes ◽  
Breast Cancers ◽  
Indian Women ◽  
Repair Genes

Value and indications of surgery in locally advanced breast cancers

1997 ◽  
Vol 33 ◽  
pp. S216
Author(s):  
C. Nos ◽  
A. Fourquet ◽  
J.M. Cosset ◽  
B. Asselain ◽  
T. Palangie ◽  
...  
Keyword(s):  
Locally Advanced ◽  
Advanced Breast ◽  
Breast Cancers

Disease-free survival pattern in breast cancer patients in India treated in a single institution.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e12030-e12030 ◽  
Author(s):  
Basavalinga S. Ajaikumar ◽  
Kodaganur Srinivasachar Gopinath ◽  
B S Srinath ◽  
Ramesh Bilimagga S ◽  
Nalini K Rao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Locally Advanced ◽  
Disease Free Survival ◽  
Advanced Breast ◽  
Breast Cancers ◽  
Breast Cancer Patients ◽  
Free Survival ◽  
Distant Failure ◽  
Her 2 ◽  
Disease Free

e12030 Background: This study elucidates data from a 5 year retrospective study evaluating survival rates and prognostic factors in breast carcinoma patients in a private cancer set up in south India. Methods: 1046 patients who were treated between years 2003 to 2008 were analyzed. Clinical data including stage, histopathology type, age, node positivity, treatment plan, chemotherapy regimen, ER/ PR and Her2 Neu status, type of surgery etc were abstracted in a database. Five year disease free survival, local failure free survival and distant failure free survival was calculated using Kaplan Meier survival curves. Log rank mantel hazel tests were used to compare two survival curves. Results: Local recurrence was seen in 4% and distant metastases in 22% of the study sample. 62% of patients presented with early breast cancer (AJCC Stage I, II and IIIA). 85.6% of early and 73.1% of locally advanced breast cancers were disease free at 5 years (p<0.001).90.6% of early and 82.4% of locally advanced breast cancers had distant failure free survival at 5 years (p=0.001). Local failure free survival was 96.1% in both early and locally advanced breast disease at 5 years.94.9% of her 2 negative and 83.5% Her 2 positive were disease free at 5 years (p=0.001). 5 years progression free survival was 91.5% for breast conservation surgery vs 84.1% for mastectomy with axillary clearance (p=0.01). 75.4% with triple negative status and 80.8% non triple negative receptor status had 5 years DFS. Conclusion: This is a first report of survival patterns of breast cancer patients treated in a single centre in India. High early stage patient numbers and high median disease free survival times could be because of improvement in screening and treatment of breast cancer in a developing country like India.

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