Effects of inner hair cell damage on temporal coding

2013 ◽  
Author(s):  
David Axe ◽  
Michael Heinz
Keyword(s):  
Hair Cell ◽  
Cell Damage ◽  
Temporal Coding ◽  
Inner Hair Cell ◽  
Hair Cell Damage

Effects of inner hair cell damage on temporal coding

2013 ◽  
Vol 133 (5) ◽  
pp. 3425-3425
Author(s):  
David R. Axe ◽  
Michael G. Heinz
Keyword(s):  
Hair Cell ◽  
Cell Damage ◽  
Temporal Coding ◽  
Inner Hair Cell ◽  
Hair Cell Damage

scholarly journals Unmyelinated type II afferent neurons report cochlear damage

2015 ◽  
Vol 112 (47) ◽  
pp. 14723-14727 ◽  
Author(s):  
Chang Liu ◽  
Elisabeth Glowatzki ◽  
Paul Albert Fuchs
Keyword(s):  
Hair Cell ◽  
Hair Cells ◽  
Outer Hair Cell ◽  
Cell Damage ◽  
Large Diameter ◽  
Outer Hair Cells ◽  
Type I ◽  
Type Ii ◽  
Inner Hair Cell ◽  
Hair Cell Damage

In the mammalian cochlea, acoustic information is carried to the brain by the predominant (95%) large-diameter, myelinated type I afferents, each of which is postsynaptic to a single inner hair cell. The remaining thin, unmyelinated type II afferents extend hundreds of microns along the cochlear duct to contact many outer hair cells. Despite this extensive arbor, type II afferents are weakly activated by outer hair cell transmitter release and are insensitive to sound. Intriguingly, type II afferents remain intact in damaged regions of the cochlea. Here, we show that type II afferents are activated when outer hair cells are damaged. This response depends on both ionotropic (P2X) and metabotropic (P2Y) purinergic receptors, binding ATP released from nearby supporting cells in response to hair cell damage. Selective activation of P2Y receptors increased type II afferent excitability by the closure of KCNQ-type potassium channels, a potential mechanism for the painful hypersensitivity (that we term “noxacusis” to distinguish from hyperacusis without pain) that can accompany hearing loss. Exposure to the KCNQ channel activator retigabine suppressed the type II fiber’s response to hair cell damage. Type II afferents may be the cochlea’s nociceptors, prompting avoidance of further damage to the irreparable inner ear.

Recording from the Inferior Colliculus Following Cochlear Inner Hair Cell Damage

1996 ◽  
Vol 116 (5) ◽  
pp. 714-720 ◽  
Author(s):  
Mark Wake ◽  
Sachio Takeno ◽  
Richard J. Mount ◽  
Robert V. Harrison
Keyword(s):  
Hair Cell ◽  
Inferior Colliculus ◽  
Cell Damage ◽  
Inner Hair Cell ◽  
Hair Cell Damage

Otoacoustic Emission Amplification After Inner Hair Cell Damage

1996 ◽  
Vol 116 (3) ◽  
pp. 374-381 ◽  
Author(s):  
Mark Wake ◽  
Jenifer Anderson ◽  
Sachio Takeno ◽  
Richard J. Mount ◽  
Robert V. Harrison
Keyword(s):  
Hair Cell ◽  
Cell Damage ◽  
Otoacoustic Emission ◽  
Inner Hair Cell ◽  
Hair Cell Damage

Hair Cell Damage in the Inner Ear of the Guinea Pig Due to Noise in a Workshop

1987 ◽  
Vol 103 (5) ◽  
pp. 204-211 ◽  
Author(s):  
B. Erlandsson ◽  
H. Hakanson ◽  
A. Ivarsson ◽  
P. Nilsson ◽  
J. Wersall
Keyword(s):  
Guinea Pig ◽  
Hair Cell ◽  
Inner Ear ◽  
Cell Damage ◽  
Hair Cell Damage

XIAP inhibits gentamicin-induced hair cell damage and ototoxicity through the caspase-3/9 pathway

2021 ◽  
pp. 114513
Author(s):  
Dekun Gao ◽  
Hui Wu ◽  
Huiqun Jie ◽  
Min Liang ◽  
Dongzhen Yu ◽  
...  
Keyword(s):  
Hair Cell ◽  
Caspase 3 ◽  
Cell Damage ◽  
Hair Cell Damage

Zebrafish swimming behavior as a biomarker for ototoxicity-induced hair cell damage: a high-throughput drug development platform targeting hearing loss

2015 ◽  
Vol 166 (5) ◽  
pp. 440-450 ◽  
Author(s):  
Maki Niihori ◽  
Terry Platto ◽  
Suzu Igarashi ◽  
Audriana Hurbon ◽  
Allison M. Dunn ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Drug Development ◽  
Hair Cell ◽  
High Throughput ◽  
Cell Damage ◽  
Swimming Behavior ◽  
Development Platform ◽  
Hair Cell Damage
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