The effect of confinement on dynamics and rheology of dilute deoxyribose nucleic acid solutions. II. Effective rheology and single chain dynamics

2004 ◽  
Vol 48 (2) ◽  
pp. 299-318 ◽  
Author(s):  
Nathanael J. Woo ◽  
Eric S. G. Shaqfeh ◽  
Bamin Khomami
Keyword(s):  
Nucleic Acid ◽  
Acid Solutions ◽  
Single Chain ◽  
Chain Dynamics ◽  
Deoxyribose Nucleic Acid

Single chain dynamics in polymer networks: A Monte Carlo study

2009 ◽  
Vol 130 (20) ◽  
pp. 204902 ◽  
Author(s):  
S. Nedelcu ◽  
J.-U. Sommer
Keyword(s):  
Monte Carlo ◽  
Polymer Networks ◽  
Monte Carlo Study ◽  
Single Chain ◽  
Chain Dynamics

scholarly journals A structure for deoxyribose nucleic acid

2003 ◽  
Vol 42 (2) ◽  
pp. 373-374 ◽  
Author(s):  
Anthony N. DeMaria
Keyword(s):  
Nucleic Acid ◽  
Deoxyribose Nucleic Acid

scholarly journals Functional stability of 3D8 scFv, a nucleic acid-hydrolyzing single chain antibody, under different biochemical and physical conditions

2015 ◽  
Vol 496 (2) ◽  
pp. 561-570 ◽  
Author(s):  
Joungmin Lee ◽  
Hyunjoon Park ◽  
Minjae Kim ◽  
Youngsil Seo ◽  
Yeonjin Lee ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Functional Stability ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Physical Conditions ◽  
3D8 Scfv

scholarly journals Broad-Spectrum Antiviral Activity of 3D8, a Nucleic Acid-Hydrolyzing Single-Chain Variable Fragment (scFv), Targeting SARS-CoV-2 and Multiple Coronaviruses In Vitro

Viruses ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 650
Author(s):  
Gunsup Lee ◽  
Shailesh Budhathoki ◽  
Geum-Young Lee ◽  
Kwang-ji Oh ◽  
Yeon Kyoung Ham ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Antiviral Activity ◽  
Broad Spectrum ◽  
Recombinant Antibody ◽  
Therapeutic Effects ◽  
Single Chain Variable Fragment ◽  
Single Chain ◽  
Diarrhea Virus ◽  
3D8 Scfv

The virus behind the current pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the etiology of novel coronavirus disease (COVID-19) and poses a critical public health threat worldwide. Effective therapeutics and vaccines against multiple coronaviruses remain unavailable. Single-chain variable fragment (scFv), a recombinant antibody, exhibits broad-spectrum antiviral activity against DNA and RNA viruses owing to its nucleic acid-hydrolyzing property. The antiviral activity of 3D8 scFv against SARS-CoV-2 and other coronaviruses was evaluated in Vero E6 cell cultures. Viral growth was quantified with quantitative RT-qPCR and plaque assay. The nucleic acid-hydrolyzing activity of 3D8 was assessed through abzyme assays of in vitro viral transcripts and cell viability was determined by MTT assay. We found that 3D8 inhibited the replication of SARS-CoV-2, human coronavirus OC43 (HCoV-OC43), and porcine epidemic diarrhea virus (PEDV). Our results revealed the prophylactic and therapeutic effects of 3D8 scFv against SARS-CoV-2 in Vero E6 cells. Immunoblot and plaque assays showed the reduction of coronavirus nucleoproteins and infectious particles, respectively, in 3D8 scFv-treated cells. These data demonstrate the broad-spectrum antiviral activity of 3D8 against SARS-CoV-2 and other coronaviruses. Thus, it could be considered a potential antiviral countermeasure against SARS-CoV-2 and zoonotic coronaviruses.

A partially incoherent rate theory of long-range charge transfer in deoxyribose nucleic acid

2002 ◽  
Vol 117 (9) ◽  
pp. 4578-4584 ◽  
Author(s):  
HouYu Zhang ◽  
Xin-Qi Li ◽  
Ping Han ◽  
Xiang Yang Yu ◽  
YiJing Yan
Keyword(s):  
Charge Transfer ◽  
Nucleic Acid ◽  
Long Range ◽  
Rate Theory ◽  
Deoxyribose Nucleic Acid

scholarly journals Assessment of sperm deoxyribose nucleic acid fragmentation using sperm chromatin dispersion assay

2017 ◽  
Vol 8 (2) ◽  
pp. 45 ◽  
Author(s):  
SumaYekappa Hottigoudar ◽  
Harsha Pratap ◽  
KuberaSiddappa Nichanahalli ◽  
Parkash Chand
Keyword(s):  
Nucleic Acid ◽  
Sperm Chromatin ◽  
Deoxyribose Nucleic Acid

Synthesis, crystal structure, deoxyribose nucleic acid interaction and antitumor activity of some thiosemicarbazonatomolybdenum(VI)

2014 ◽  
Vol 421 ◽  
pp. 270-283 ◽  
Author(s):  
Mouayed A. Hussein ◽  
Teoh S. Guan ◽  
Rosenani A. Haque ◽  
Mohamed B. Khadeer Ahamed ◽  
Amin M.S. Abdul Majid
Keyword(s):  
Crystal Structure ◽  
Nucleic Acid ◽  
Antitumor Activity ◽  
Acid Interaction ◽  
Deoxyribose Nucleic Acid
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