Association of Exercise-Induced Bronchospasm with Obesity

Exercise-induced bronchospasm (EIB) is present in many patients with asthma or with a family history of atopy. A review was made of exercise provocation testing performed on 37 children ages 5 to 17 years. Maximal forced expiratory maneuvers were performed before and serially every 3 minutes after a 7-min run/walk. A positive result was defined as a fall of at least 15% in FEV, or PEFR or 25% in FEF25-75 at some point within 20 min postexercise. A total of 27 out of 37 patients in this select group had positive tests (73%), with a mean fall in FEF25-75 of 31.9%. Of these 27 children with EIB, 16 had a history of atopy, 23 had clinical symptoms of EIB, and 21 were overweight. Of the 12 nonatopic children with EIB, 9 were overweight, with a mean fall in FEF25-75 of 32.1%. These 9 came from a total pool of 10 overweight, nonatopic children (90%). Being overweight was associated with a high incidence of EIB independent of a history of atopic disease.

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Incidence of Mitral Valve Prolapse in Adolescent Scoliosis and Thoracic Hypokyphosis

PEDIATRICS ◽

10.1542/peds.70.3.451 ◽

1982 ◽

Vol 70 (3) ◽

pp. 451-454

Author(s):

Stephen S. Hirschfeld ◽

Charles Rudner ◽

Clyde L. Nash ◽

Eliezer Nussbaum ◽

Eleanor M. Brower

Keyword(s):

Family History ◽

Mitral Valve ◽

Mitral Valve Prolapse ◽

Soft Tissue Defect ◽

Skeletal Abnormality ◽

Degree Relative ◽

Familial History ◽

High Incidence ◽

History Of ◽

Echocardiographic Evidence

Seventy-four patients with adolescent scoliosis underwent cardiac examination and M-mode echocardiography to detect the presence of mitral valve prolapse (MVP). Twenty-one (28%) had echocardiographic evidence of MVP, whereas 18 had auscultatory findings of a nonejection click or late systolic murmur. A subset of 41 patients had a family history of scoliosis and 37% had MVP. The incidence of MVP increased to 41% when a first degree relative, such as a sibling, parent, or offspring, had scoliosis. Thirty-six patients with scoliosis had additional thoracic hypokyphosis (straight back) and 13 (36%) had MVP. The incidence of MVP was 48% when the scoliosis and hypokyphosis were hereditary and increased to 53% when a familial history of skeletal abnormality was present. This study indicates a high incidence of MVP in patients with scoliosis and hypokyphosis, especially when the skeletal abnormality is familial. It suggests that the cardiac and skeletal systems may be affected by a generalized soft-tissue defect.

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Differences in exercise induced metabolic changes in normotensive patients with and without a family history of hypertension.

American Journal of Hypertension ◽

10.1016/0895-7061(95)97926-i ◽

1995 ◽

Vol 8 (4) ◽

pp. 151A

Author(s):

J NEUTEL

Keyword(s):

Family History ◽

Metabolic Changes ◽

History Of ◽

Family History Of Hypertension ◽

Exercise Induced

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Variant acute intermittent porphyria in a child

Clinical Chemistry ◽

10.1093/clinchem/36.5.812 ◽

1990 ◽

Vol 36 (5) ◽

pp. 812-814 ◽

Cited By ~ 2

Author(s):

N R Badcock ◽

G D Zoanetti ◽

D A O'Reilly ◽

E F Robertson

Keyword(s):

Family History ◽

Parenteral Nutrition ◽

Enzyme Activities ◽

Clinical Symptoms ◽

Acute Intermittent Porphyria ◽

Normal Activity ◽

Porphobilinogen Deaminase ◽

Acute Porphyria ◽

Protoporphyrinogen Oxidase ◽

History Of

Abstract A child who was grossly malnourished and who showed increased excretion of porphyrin and porphyrin precursor had normal activity of erythrocyte porphobilinogen deaminase (EC 4.3.1.8) and leukocyte protoporphyrinogen oxidase (EC 1.3.3.4). Clinical symptoms, coincident with the excretion of rose-colored urine, were consistent with the diagnosis of an acute porphyria. The disease resolved spontaneously after the withdrawal of carbamazepine and sodium valproate and the commencement of parenteral nutrition with subsequent carbohydrate loading. In addition to normal concentrations of enzyme activities, the patient is unusual in presenting before puberty and in having no family history of porphyria.

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Prevalence of allergen sensitization, most important allergens and factors associated with atopy in children

Sao Paulo Medical Journal ◽

10.1590/1516-3180.2013.1315502 ◽

2013 ◽

Vol 131 (5) ◽

pp. 301-308 ◽

Cited By ~ 7

Author(s):

Raquel Prudente de Carvalho Baldacara ◽

Maria de Fatima Marcelos Fernandes ◽

Leonardo Baldacara ◽

Wilson Tartuce Aun ◽

Joao Ferreira de Mello ◽

...

Keyword(s):

Family History ◽

Skin Prick Test ◽

Cesarean Delivery ◽

Atopic Disease ◽

Dermatophagoides Pteronyssinus ◽

Outpatient Clinics ◽

Positive Skin Prick Test ◽

Positive Skin ◽

Prick Test ◽

History Of

CONTEXT AND OBJECTIVE: Knowledge of the profile of allergen sensitization among children is important for planning preventive measures. The objective of this study was to assess the prevalence and profile of sensitization to inhaled allergens and food among children and adolescents in an outpatient population in the city of Palmas. DESIGN AND SETTING: Cross-sectional study at outpatient clinics in Palmas, Tocantins, Brazil. METHODS: Ninety-four patients aged 1-15 years who were attending two pediatric outpatient clinics were selected between September and November 2008. All of the subjects underwent clinical interviews and skin prick tests. RESULTS: A positive skin prick test was observed in 76.6% of the participants (72.3% for inhalants and 28.9% for food allergens). The most frequent allergens were Dermatophagoides pteronyssinus (34%), cat epithelium (28.7%), dog epithelium (21.3%), Dermatophagoides farinae (19.1%), Blomia tropicalis (18.1%), cow's milk (9.6%) and grasses (9.6%). A positive skin prick test correlated with a history of atopic disease (odds ratio, OR = 5.833; P = 0.002), a family history of atopic disease (OR = 8.400; P < 0.001), maternal asthma (OR = 8.077; P = 0.048), pet exposure (OR = 3.600; P = 0.012) and cesarean delivery (OR = 3.367; P = 0.019). CONCLUSION: Dermatophagoides pteronyssinus was the most frequent aeroallergen and cow’s milk was the most prevalent food allergen. There was a positive correlation between a positive skin prick test and several factors, such as a family history of atopic disease, maternal asthma, pet exposure and cesarean delivery.

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The Effect of Organophosphorus Compounds on Serum Pseudocholinesterase Levels in a Group of Industrial Workers

Human & Experimental Toxicology ◽

10.1177/096032719101000406 ◽

1991 ◽

Vol 10 (4) ◽

pp. 275-278 ◽

Cited By ~ 8

Author(s):

Jacob Peedicayil ◽

Kalpana Ernest ◽

Molly Thomas ◽

A.S. Kanagasabapathy ◽

P.M. Stephen

Keyword(s):

Clinical Symptoms ◽

Organophosphorus Compounds ◽

Industrial Workers ◽

Normal Range ◽

High Incidence ◽

Exposed Workers ◽

History Of ◽

The Mean ◽

Symptoms And Signs ◽

Low Serum

This paper presents the findings of a study of serum pseudocholinesterase activity in a group of 36 industrial workers chronically exposed to organophosphorus (OP) compounds. The mean pseudocholinesterase level of the workers was significantly lower than that of 36 other workers without a history of similar exposure. Although there was a high incidence of clinical features suggestive of OP compound toxicity in the exposed workers, no significant correlation between serum pseudocholinesterase levels and clinical symptoms and signs was found. Six exposed workers, found to have low serum pseudocholinesterase levels, were transferred for 6 months to work areas which did not involve OP exposure, whereupon their levels rose significantly back to the normal range.

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Influence of Family History of Neurodegenerative Diseases on Outcome Following Pediatric Concussion

Neurology ◽

10.1212/01.wnl.0000580896.02091.91 ◽

2019 ◽

Vol 93 (14 Supplement 1) ◽

pp. S7.2-S8

Author(s):

Colt Coffman ◽

Jacob Kay ◽

Adam Harrison ◽

Jeffery Holloway ◽

Robert Davis Moore

Keyword(s):

Family History ◽

Neurodegenerative Disease ◽

Clinical Symptoms ◽

Cognitive Outcomes ◽

Group Differences ◽

Post Injury ◽

Pediatric Concussion ◽

History Of ◽

Concussion History ◽

Data Group

ObjectiveTo longitudinally evaluate the relation between family history of neurodegenerative disease and clinical symptoms, as well as vestibular-ocular and cognitive outcomes following concussion in children.BackgroundResearch indicates that pediatric concussion may lead to chronic alterations in neuropsychological health that can adversely affect neurodevelopment. Therefore, it is critical to identify risk factors that may moderate recovery to improve concussion outcomes in children. Evidence suggests that one such moderator may be a family history of neurodegenerative disease (FHND).Design/MethodsData were collected from a local pediatric concussion clinic. Patients were examined at 2- and 5-weeks post-injury. Clinical symptoms were measured using the Rivermead Post-Concussion Symptoms Questionnaire (RPQ). Vestibular-ocular function was assessed using the Vestibular/Ocular Motor Screening (VOMS) tool. Cognition was measured using a modified CogState Brain Injury Test Battery. Log-transformations were applied to normalize data. Group differences between those with (n = 13) and without (n = 26) a family history of neurodegenerative disease (Alzheimer’s, Non-Alzheimer’s Dementias, Parkinson’s, and/or Multiple Sclerosis) were analyzed. Children without FHND were double-matched based on sex, age, and concussion history.ResultsAcross timepoints, children with FHND reported more severe clinical symptoms on the RPQ (p’s < 0.05). Additionally, those with FHND showed higher VOMS saccades scores across timepoints compared to those without FHND (p’s < 0.05). Further, children with FHND reported greater dizziness following VOMS saccades and convergence tests at 5-weeks post-injury (p’s < 0.01). No group differences at any timepoint were observed for any measure of cognition.ConclusionsOur findings indicate that a family history of neurodegenerative disease is associated with more severe clinical symptoms and greater vestibular-ocular dysfunction following pediatric concussion.

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Family History of Diabetes Does Not Affect Exercise-Induced Improvements in Insulin Sensitivity and Metabolic Flexibility

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000535811.38272.40 ◽

2018 ◽

Vol 50 (5S) ◽

pp. 220

Author(s):

Manuel Amador ◽

Cesar Meza ◽

Mario Garcia ◽

Christopher Figueroa ◽

George King ◽

...

Keyword(s):

Insulin Sensitivity ◽

Family History ◽

Metabolic Flexibility ◽

Family History Of Diabetes ◽

History Of ◽

Exercise Induced

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The Psychopathology of the Gilles de la Tourette Syndrome

The British Journal of Psychiatry ◽

10.1192/bjp.152.3.383 ◽

1988 ◽

Vol 152 (3) ◽

pp. 383-390 ◽

Cited By ~ 183

Author(s):

Mary M. Robertson ◽

Michael R. Trimble ◽

A. J. Lees

Keyword(s):

Family History ◽

Tourette Syndrome ◽

High Incidence ◽

History Of

Ninety patients with the Gilles de la Tourette syndrome were studied. A high incidence of depression, hostility, and obsessionality was found. Depression was not related to administered medication, while aggression, hostility, and obsessionality were significantly associated with some important features of the syndrome, namely copro- and echo-phenomena and a family history of tics or the Gilles de la Tourette syndrome. Links between psychopathology and neurological and electroencephalographic abnormalities were minimal.

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