Glycemic Control and Chronic Dosing of Rhesus Monkeys with a Fusion Protein of Iduronidase and a Monoclonal Antibody Against the Human Insulin Receptor

Drug Metabolism and Disposition ◽

10.1124/dmd.112.046375 ◽

2012 ◽

Vol 40 (10) ◽

pp. 2021-2025 ◽

Author(s):

Ruben J. Boado ◽

Eric Ka-Wai Hui ◽

Jeff Zhiqiang Lu ◽

William M. Pardridge

Keyword(s):

Monoclonal Antibody ◽

Glycemic Control ◽

Fusion Protein ◽

Insulin Receptor ◽

Human Insulin ◽

Rhesus Monkeys ◽

Human Insulin Receptor

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Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor

Biotechnology and Bioengineering ◽

10.1002/bit.24795 ◽

2012 ◽

Vol 110 (5) ◽

pp. 1456-1465 ◽

Author(s):

Ruben J. Boado ◽

Jeff Zhiqiang Lu ◽

Eric K.-W. Hui ◽

Rachita K. Sumbria ◽

William M. Pardridge

Keyword(s):

Monoclonal Antibody ◽

Rhesus Monkey ◽

Fusion Protein ◽

Insulin Receptor ◽

Human Insulin ◽

Brain Uptake ◽

Arylsulfatase A ◽

Human Insulin Receptor

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Anti-drug antibody response in mucopolysaccharidosis type I patients treated with AGT-181, a brain penetrating human insulin receptor antibody-iduronidase fusion protein

Molecular Genetics and Metabolism ◽

10.1016/j.ymgme.2017.12.343 ◽

2018 ◽

Vol 123 (2) ◽

pp. S126 ◽

Author(s):

Mathias Schmidt ◽

Ruben J. Boado ◽

Roberto Giugliani ◽

William M. Pardridge

Keyword(s):

Antibody Response ◽

Fusion Protein ◽

Insulin Receptor ◽

Human Insulin ◽

Type I ◽

Mucopolysaccharidosis Type ◽

Mucopolysaccharidosis Type I ◽

Receptor Antibody ◽

Human Insulin Receptor

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Safety and clinical efficacy of AGT-181, a brain penetrating human insulin receptor antibody-iduronidase fusion protein, in a 26-week study with pediatric patients with mucopolysaccharidosis type I

Molecular Genetics and Metabolism ◽

10.1016/j.ymgme.2017.12.128 ◽

2018 ◽

Vol 123 (2) ◽

pp. S54 ◽

Author(s):

Roberto Giugliani ◽

Luciana Giugliani ◽

Amauri Dalla Corte ◽

Fabiano Poswar ◽

Karina Donis ◽

...

Keyword(s):

Fusion Protein ◽

Insulin Receptor ◽

Human Insulin ◽

Clinical Efficacy ◽

Pediatric Patients ◽

Type I ◽

Mucopolysaccharidosis Type ◽

Mucopolysaccharidosis Type I ◽

Receptor Antibody ◽

Human Insulin Receptor

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Functional activation of mutant human insulin receptor by monoclonal antibody

10.1016/s0140-6736(96)91076-4 ◽

1996 ◽

Vol 347 (9015) ◽

pp. 1586-1590 ◽

Author(s):

A Krook ◽

M.A Soos ◽

S O'Rahilly ◽

A Krook ◽

M.A Soos ◽

...

Keyword(s):

Monoclonal Antibody ◽

Insulin Receptor ◽

Human Insulin ◽

Human Insulin Receptor

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Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor.

Journal of Clinical Investigation ◽

10.1172/jci119708 ◽

1997 ◽

Vol 100 (7) ◽

pp. 1804-1812 ◽

Author(s):

D Wu ◽

J Yang ◽

W M Pardridge

Keyword(s):

Monoclonal Antibody ◽

Insulin Receptor ◽

Blood Brain Barrier ◽

Human Insulin ◽

Drug Targeting ◽

Brain Barrier ◽

Blood Brain ◽

Human Insulin Receptor

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Monoclonal antibody to the human insulin receptor, but not insulin, stimulates S6 kinase via human insulin receptors mutated at three major tyrosine autophosphorylation sites

Journal of Cellular Biochemistry ◽

10.1002/jcb.240480313 ◽

1992 ◽

Vol 48 (3) ◽

pp. 324-335 ◽

Author(s):

Chin K. Sung

Keyword(s):

Monoclonal Antibody ◽

Insulin Receptor ◽

Human Insulin ◽

Insulin Receptors ◽

S6 Kinase ◽

Human Insulin Receptor ◽

Tyrosine Autophosphorylation

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Very High Plasma Concentrations of a Monoclonal Antibody against the Human Insulin Receptor Are Produced by Subcutaneous Injection in the Rhesus Monkey

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.6b00456 ◽

2016 ◽

Vol 13 (9) ◽

pp. 3241-3246 ◽

Author(s):

Ruben J. Boado ◽

Eric Ka-Wai Hui ◽

Jeff Zhiqiang Lu ◽

William M. Pardridge

Keyword(s):

Monoclonal Antibody ◽

Rhesus Monkey ◽

Insulin Receptor ◽

Human Insulin ◽

Subcutaneous Injection ◽

Plasma Concentrations ◽

High Plasma ◽

Human Insulin Receptor ◽

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Plasma Pharmacokinetics of Valanafusp Alpha, a Human Insulin Receptor Antibody-Iduronidase Fusion Protein, in Patients with Mucopolysaccharidosis Type I

BioDrugs ◽

10.1007/s40259-018-0264-7 ◽

2018 ◽

Vol 32 (2) ◽

pp. 169-176 ◽

Author(s):

William M. Pardridge ◽

Ruben J. Boado ◽

Roberto Giugliani ◽

Mathias Schmidt

Keyword(s):

Fusion Protein ◽

Insulin Receptor ◽

Human Insulin ◽

Type I ◽

Mucopolysaccharidosis Type ◽

Mucopolysaccharidosis Type I ◽

Receptor Antibody ◽

Human Insulin Receptor ◽

Plasma Pharmacokinetics

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Plasma pharmacokinetics of a human insulin receptor antibody-iduronidase fusion protein in patients with mucopolysaccharidosis type I

Molecular Genetics and Metabolism ◽

10.1016/j.ymgme.2017.12.303 ◽

2018 ◽

Vol 123 (2) ◽

pp. S113

Author(s):

William M. Pardridge ◽

Ruben J. Boado ◽

Roberto Giugliani ◽

Mathias Schmidt

Keyword(s):

Fusion Protein ◽

Insulin Receptor ◽

Human Insulin ◽

Type I ◽

Mucopolysaccharidosis Type ◽

Mucopolysaccharidosis Type I ◽

Receptor Antibody ◽

Human Insulin Receptor ◽

Plasma Pharmacokinetics

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A monoclonal antibody to human insulin receptor

Biochemical and Biophysical Research Communications ◽

10.1016/0006-291x(82)91813-7 ◽

1982 ◽

Vol 106 (3) ◽

pp. 1019-1026 ◽

Author(s):

Frederick C. Kull ◽

Steven Jacobs ◽

Ying-Fu Su ◽

Pedro Cuatrecasas

Keyword(s):

Monoclonal Antibody ◽

Insulin Receptor ◽

Human Insulin ◽

Human Insulin Receptor

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