Safety and clinical efficacy of AGT-181, a brain penetrating human insulin receptor antibody-iduronidase fusion protein, in a 26-week study with pediatric patients with mucopolysaccharidosis type I

Receptor Antibody ◽

Anti-drug antibody response in mucopolysaccharidosis type I patients treated with AGT-181, a brain penetrating human insulin receptor antibody-iduronidase fusion protein

Molecular Genetics and Metabolism ◽

10.1016/j.ymgme.2017.12.343 ◽

2018 ◽

Vol 123 (2) ◽

pp. S126 ◽

Cited By ~ 3

Author(s):

Mathias Schmidt ◽

Ruben J. Boado ◽

Roberto Giugliani ◽

William M. Pardridge

Keyword(s):

Antibody Response ◽

Fusion Protein ◽

Insulin Receptor ◽

Human Insulin ◽

Type I ◽

Receptor Antibody ◽

Plasma Pharmacokinetics of Valanafusp Alpha, a Human Insulin Receptor Antibody-Iduronidase Fusion Protein, in Patients with Mucopolysaccharidosis Type I

BioDrugs ◽

10.1007/s40259-018-0264-7 ◽

2018 ◽

Vol 32 (2) ◽

pp. 169-176 ◽

Cited By ~ 13

Author(s):

William M. Pardridge ◽

Ruben J. Boado ◽

Roberto Giugliani ◽

Mathias Schmidt

Keyword(s):

Fusion Protein ◽

Insulin Receptor ◽

Human Insulin ◽

Type I ◽

Receptor Antibody ◽

Human Insulin Receptor ◽

Plasma Pharmacokinetics

Plasma pharmacokinetics of a human insulin receptor antibody-iduronidase fusion protein in patients with mucopolysaccharidosis type I

Molecular Genetics and Metabolism ◽

10.1016/j.ymgme.2017.12.303 ◽

2018 ◽

Vol 123 (2) ◽

pp. S113

Author(s):

William M. Pardridge ◽

Ruben J. Boado ◽

Roberto Giugliani ◽

Mathias Schmidt

Keyword(s):

Fusion Protein ◽

Insulin Receptor ◽

Human Insulin ◽

Type I ◽

Receptor Antibody ◽

Human Insulin Receptor ◽

Plasma Pharmacokinetics

Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (valanafusp alpha): an open label phase 1-2 trial

Orphanet Journal of Rare Diseases ◽

10.1186/s13023-018-0849-8 ◽

2018 ◽

Vol 13 (1) ◽

Cited By ~ 33

Author(s):

Roberto Giugliani ◽

Luciana Giugliani ◽

Fabiano de Oliveira Poswar ◽

Karina Carvalho Donis ◽

Amauri Dalla Corte ◽

...

Keyword(s):

Fusion Protein ◽

Insulin Receptor ◽

Pediatric Patients ◽

Phase 1 ◽

Type I ◽

Open Label ◽

Receptor Antibody ◽

Open Label Phase

Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor

Biotechnology and Bioengineering ◽

10.1002/bit.24795 ◽

2012 ◽

Vol 110 (5) ◽

pp. 1456-1465 ◽

Cited By ~ 32

Author(s):

Ruben J. Boado ◽

Jeff Zhiqiang Lu ◽

Eric K.-W. Hui ◽

Rachita K. Sumbria ◽

William M. Pardridge

Keyword(s):

Monoclonal Antibody ◽

Rhesus Monkey ◽

Fusion Protein ◽

Insulin Receptor ◽

Human Insulin ◽

Brain Uptake ◽

Arylsulfatase A ◽

Humanization of anti-human insulin receptor antibody for drug targeting across the human blood–brain barrier

Biotechnology and Bioengineering ◽

10.1002/bit.21120 ◽

2006 ◽

Vol 96 (2) ◽

pp. 381-391 ◽

Cited By ~ 127

Author(s):

Ruben J. Boado ◽

Yufeng Zhang ◽

Yun Zhang ◽

William M. Pardridge

Keyword(s):

Insulin Receptor ◽

Blood Brain Barrier ◽

Human Insulin ◽

Human Blood ◽

Drug Targeting ◽

Brain Barrier ◽

Receptor Antibody ◽

Blood Brain ◽

Glycemic Control and Chronic Dosing of Rhesus Monkeys with a Fusion Protein of Iduronidase and a Monoclonal Antibody Against the Human Insulin Receptor

Drug Metabolism and Disposition ◽

10.1124/dmd.112.046375 ◽

2012 ◽

Vol 40 (10) ◽

pp. 2021-2025 ◽

Cited By ~ 28

Author(s):

Ruben J. Boado ◽

Eric Ka-Wai Hui ◽

Jeff Zhiqiang Lu ◽

William M. Pardridge

Keyword(s):

Monoclonal Antibody ◽

Glycemic Control ◽

Fusion Protein ◽

Insulin Receptor ◽

Human Insulin ◽

Rhesus Monkeys ◽

Human insulin-receptor gene. Partial sequence and amplification of exons by polymerase chain reaction

Diabetes ◽

10.2337/diabetes.39.1.123 ◽

1990 ◽

Vol 39 (1) ◽

pp. 123-128 ◽

Cited By ~ 16

Author(s):

S. Seino ◽

M. Seino ◽

G. I. Bell

Keyword(s):

Polymerase Chain Reaction ◽

Insulin Receptor ◽

Human Insulin ◽

Receptor Gene ◽

Partial Sequence ◽

Chain Reaction ◽

Insulin Receptor Gene ◽

Human Insulin Receptor ◽

Polymerase Chain

Substitution of lysine for asparagine at position 15 in the alpha-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affinity of insulin binding.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)30636-1 ◽

1990 ◽

Vol 265 (31) ◽

pp. 19143-19150

Author(s):

T Kadowaki ◽

H Kadowaki ◽

D Accili ◽

S.I. Taylor

Keyword(s):

Cell Surface ◽

Insulin Receptor ◽

Human Insulin ◽

Insulin Binding ◽

Alpha Subunit ◽

Deletion analysis of the human insulin receptor ectodomain reveals independently folded soluble subdomains and insulin binding by a monomeric alpha-subunit.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)38291-2 ◽

1990 ◽

Vol 265 (22) ◽

pp. 13248-13253 ◽

Cited By ~ 1

Author(s):

E M Schaefer ◽

K Siddle ◽

L Ellis

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Insulin Binding ◽

Deletion Analysis ◽

Alpha Subunit ◽