Very High Plasma Concentrations of a Monoclonal Antibody against the Human Insulin Receptor Are Produced by Subcutaneous Injection in the Rhesus Monkey

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.6b00456 ◽

2016 ◽

Vol 13 (9) ◽

pp. 3241-3246 ◽

Author(s):

Ruben J. Boado ◽

Eric Ka-Wai Hui ◽

Jeff Zhiqiang Lu ◽

William M. Pardridge

Keyword(s):

Monoclonal Antibody ◽

Rhesus Monkey ◽

Insulin Receptor ◽

Human Insulin ◽

Subcutaneous Injection ◽

Plasma Concentrations ◽

High Plasma ◽

Human Insulin Receptor ◽

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Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor

Biotechnology and Bioengineering ◽

10.1002/bit.24795 ◽

2012 ◽

Vol 110 (5) ◽

pp. 1456-1465 ◽

Author(s):

Ruben J. Boado ◽

Jeff Zhiqiang Lu ◽

Eric K.-W. Hui ◽

Rachita K. Sumbria ◽

William M. Pardridge

Keyword(s):

Monoclonal Antibody ◽

Rhesus Monkey ◽

Fusion Protein ◽

Insulin Receptor ◽

Human Insulin ◽

Brain Uptake ◽

Arylsulfatase A ◽

Human Insulin Receptor

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Functional activation of mutant human insulin receptor by monoclonal antibody

10.1016/s0140-6736(96)91076-4 ◽

1996 ◽

Vol 347 (9015) ◽

pp. 1586-1590 ◽

Author(s):

A Krook ◽

M.A Soos ◽

S O'Rahilly ◽

A Krook ◽

M.A Soos ◽

...

Keyword(s):

Monoclonal Antibody ◽

Insulin Receptor ◽

Human Insulin ◽

Human Insulin Receptor

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Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor.

Journal of Clinical Investigation ◽

10.1172/jci119708 ◽

1997 ◽

Vol 100 (7) ◽

pp. 1804-1812 ◽

Author(s):

D Wu ◽

J Yang ◽

W M Pardridge

Keyword(s):

Monoclonal Antibody ◽

Insulin Receptor ◽

Blood Brain Barrier ◽

Human Insulin ◽

Drug Targeting ◽

Brain Barrier ◽

Blood Brain ◽

Human Insulin Receptor

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Monoclonal antibody to the human insulin receptor, but not insulin, stimulates S6 kinase via human insulin receptors mutated at three major tyrosine autophosphorylation sites

Journal of Cellular Biochemistry ◽

10.1002/jcb.240480313 ◽

1992 ◽

Vol 48 (3) ◽

pp. 324-335 ◽

Author(s):

Chin K. Sung

Keyword(s):

Monoclonal Antibody ◽

Insulin Receptor ◽

Human Insulin ◽

Insulin Receptors ◽

S6 Kinase ◽

Human Insulin Receptor ◽

Tyrosine Autophosphorylation

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A monoclonal antibody to human insulin receptor

Biochemical and Biophysical Research Communications ◽

10.1016/0006-291x(82)91813-7 ◽

1982 ◽

Vol 106 (3) ◽

pp. 1019-1026 ◽

Author(s):

Frederick C. Kull ◽

Steven Jacobs ◽

Ying-Fu Su ◽

Pedro Cuatrecasas

Keyword(s):

Monoclonal Antibody ◽

Insulin Receptor ◽

Human Insulin ◽

Human Insulin Receptor

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Glycemic Control and Chronic Dosing of Rhesus Monkeys with a Fusion Protein of Iduronidase and a Monoclonal Antibody Against the Human Insulin Receptor

Drug Metabolism and Disposition ◽

10.1124/dmd.112.046375 ◽

2012 ◽

Vol 40 (10) ◽

pp. 2021-2025 ◽

Author(s):

Ruben J. Boado ◽

Eric Ka-Wai Hui ◽

Jeff Zhiqiang Lu ◽

William M. Pardridge

Keyword(s):

Monoclonal Antibody ◽

Glycemic Control ◽

Fusion Protein ◽

Insulin Receptor ◽

Human Insulin ◽

Rhesus Monkeys ◽

Human Insulin Receptor

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Human insulin-receptor gene. Partial sequence and amplification of exons by polymerase chain reaction

Diabetes ◽

10.2337/diabetes.39.1.123 ◽

1990 ◽

Vol 39 (1) ◽

pp. 123-128 ◽

Author(s):

S. Seino ◽

M. Seino ◽

G. I. Bell

Keyword(s):

Polymerase Chain Reaction ◽

Insulin Receptor ◽

Human Insulin ◽

Receptor Gene ◽

Partial Sequence ◽

Chain Reaction ◽

Insulin Receptor Gene ◽

Human Insulin Receptor ◽

Polymerase Chain

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Substitution of lysine for asparagine at position 15 in the alpha-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affinity of insulin binding.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)30636-1 ◽

1990 ◽

Vol 265 (31) ◽

pp. 19143-19150

Author(s):

T Kadowaki ◽

H Kadowaki ◽

D Accili ◽

S.I. Taylor

Keyword(s):

Cell Surface ◽

Insulin Receptor ◽

Human Insulin ◽

Insulin Binding ◽

Alpha Subunit ◽

Human Insulin Receptor

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Deletion analysis of the human insulin receptor ectodomain reveals independently folded soluble subdomains and insulin binding by a monomeric alpha-subunit.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)38291-2 ◽

1990 ◽

Vol 265 (22) ◽

pp. 13248-13253 ◽

Author(s):

E M Schaefer ◽

K Siddle ◽

L Ellis

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Insulin Binding ◽

Deletion Analysis ◽

Alpha Subunit ◽

Human Insulin Receptor

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Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)50389-1 ◽

1992 ◽

Vol 267 (13) ◽

pp. 9065-9070

Author(s):

Y Takata ◽

N.J. Webster ◽

J.M. Olefsky

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Intracellular Signaling ◽

Human Insulin Receptor ◽

Carboxyl Terminal ◽

Tyrosine Autophosphorylation

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