Species Difference in the Mechanism of Nonlinear Pharmacokinetics of E2074, a Novel Sodium Channel Inhibitor, in Rats, Dogs, and Monkeys

Yoko Nagaya; Osamu Takenaka; Kazutomi Kusano; Tsutomu Yoshimura

doi:10.1124/dmd.112.050062

Species Difference in the Mechanism of Nonlinear Pharmacokinetics of E2074, a Novel Sodium Channel Inhibitor, in Rats, Dogs, and Monkeys

Drug Metabolism and Disposition ◽

10.1124/dmd.112.050062 ◽

2013 ◽

Vol 41 (5) ◽

pp. 1004-1011 ◽

Cited By ~ 6

Author(s):

Yoko Nagaya ◽

Osamu Takenaka ◽

Kazutomi Kusano ◽

Tsutomu Yoshimura

Keyword(s):

Sodium Channel ◽

Species Difference ◽

Nonlinear Pharmacokinetics

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Assessment and Confirmation of Species Difference in Nonlinear Pharmacokinetics of Atipamezole with Physiologically Based Pharmacokinetic Modeling

Drug Metabolism and Disposition ◽

10.1124/dmd.119.089151 ◽

2019 ◽

Vol 48 (1) ◽

pp. 41-51 ◽

Cited By ~ 1

Author(s):

Zheng Li ◽

You Gao ◽

Chunmiao Yang ◽

Yanan Xiang ◽

Wenpeng Zhang ◽

...

Keyword(s):

Species Difference ◽

Pharmacokinetic Modeling ◽

Nonlinear Pharmacokinetics ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Sodium channel gene linked to epilepsy syndrome

Nature Middle East ◽

10.1038/nmiddleeast.2013.177 ◽

2013 ◽

Author(s):

Aisha El-Awady

Keyword(s):

Sodium Channel ◽

Epilepsy Syndrome ◽

Channel Gene ◽

Sodium Channel Gene

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Assessment of the Nav1.2 sodium channel activity of Aconitum diterpene and norditerpene alkaloids

Planta Medica ◽

10.1055/s-0033-1352386 ◽

2013 ◽

Vol 79 (13) ◽

Cited By ~ 1

Author(s):

B Borcsa ◽

L Fodor ◽

D Csupor ◽

P Forgo ◽

J Hohmann

Keyword(s):

Sodium Channel ◽

Channel Activity ◽

Norditerpene Alkaloids

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The Voltage-Gated Sodium Channel Nav1.2 Contributes to Neurodegeneration in an Animal Model of Multiple Sclerosis

Neuropediatrics ◽

10.1055/s-0036-1583723 ◽

2016 ◽

Vol 47 (S 01) ◽

Author(s):

W. Fazeli ◽

B. Schattling ◽

B. Engeland ◽

M. Friese ◽

D. Isbrand

Keyword(s):

Multiple Sclerosis ◽

Animal Model ◽

Sodium Channel ◽

Voltage Gated Sodium Channel ◽

Voltage Gated

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Testosterone increases expression of the alpha-subunit of the epithelial sodium channel (alpha-ENAC) in the human renal cell line HKC-8

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2005-862797 ◽

2005 ◽

Vol 113 (S 1) ◽

Author(s):

M Quinkler ◽

IJ Bujalska ◽

K Kaur ◽

CU Onyimba ◽

SV Hughes ◽

...

Keyword(s):

Sodium Channel ◽

Cell Line ◽

Renal Cell ◽

Epithelial Sodium Channel ◽

Alpha Subunit ◽

Renal Cell Line

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Testosterone treatment in rats increases expression of the alpha-subunit of the epithelial sodium channel (alpha-ENaC) in the kidney

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-2006-933061 ◽

2006 ◽

Vol 114 (S 1) ◽

Author(s):

T Kienitz ◽

B Allolio ◽

C Strasburger ◽

M Quinkler

Keyword(s):

Sodium Channel ◽

Epithelial Sodium Channel ◽

Alpha Subunit ◽

Testosterone Treatment

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Relationship Between the para-Homologous Sodium Channel Point Mutation (g → c at Nucleotide 2979) and Knockdown Resistance in the German Cockroach Using Multiplex Polymerase Chain Reaction to Discern Genotype

Journal of Economic Entomology ◽

10.1603/0022-0493-96.3.885 ◽

2003 ◽

Vol 96 (3) ◽

pp. 885-891 ◽

Cited By ~ 1

Author(s):

Steven M. Valles ◽

Omaththage P. Perera ◽

Charles A. Strong

Keyword(s):

Polymerase Chain Reaction ◽

Sodium Channel ◽

Point Mutation ◽

Multiplex Polymerase Chain Reaction ◽

German Cockroach ◽

Knockdown Resistance ◽

Chain Reaction ◽

Polymerase Chain

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Association between three mutations, F1565C, V1023G and S996P, in the voltage-sensitive sodium channel gene and knockdown resistance (kdr) inAedes aegyptifrom Yogyakarta, Indonesia

10.1603/ice.2016.113299 ◽

2016 ◽

Author(s):

Juli Wuliandari

Keyword(s):

Sodium Channel ◽

Knockdown Resistance ◽

Channel Gene ◽

Sodium Channel Gene

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Faculty Opinions recommendation of Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1015534.197407 ◽

2003 ◽

Author(s):

Elior Peles

Keyword(s):

Sodium Channel ◽

Diffusion Barrier ◽

Node Of Ranvier

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Faculty Opinions recommendation of WNK1 activates SGK1 to regulate the epithelial sodium channel.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1026824.326488 ◽

2005 ◽

Author(s):

David Cook

Keyword(s):

Sodium Channel ◽

Epithelial Sodium Channel

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