scholarly journals Correction to “Single Nucleotide Polymorphisms (SNPs) Distant from Xenobiotic Response Elements Can Modulate Aryl Hydrocarbon Receptor Function: SNP-Dependent CYP1A1 Induction”

2019 ◽  
Vol 47 (3) ◽  
pp. 270-270
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Aryl Hydrocarbon Receptor ◽  
Nucleotide Polymorphisms ◽  
Receptor Function ◽  
Single Nucleotide ◽  
Response Elements ◽  
Aryl Hydrocarbon ◽  
Cyp1a1 Induction ◽  
Xenobiotic Response

scholarly journals Analysis of association of single nucleotide polymorphisms of genes for aryl hydrocarbon receptor signaling pathway with predisposition to uterine fibroids

2020 ◽  
pp. 55-57
Author(s):  
О.Б. Полшведкина ◽  
И.Н. Вдовина ◽  
С.М. Зайцев ◽  
А.А. Клиновская ◽  
Л.А. Пономарева ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Aryl Hydrocarbon Receptor ◽  
Signaling Pathway ◽  
Uterine Fibroids ◽  
Receptor Signaling ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Aryl Hydrocarbon ◽  
Central Russia ◽  
Receptor Signaling Pathway

В исследование были включены 603 пациентки с миомой матки и 398 женщин контрольной группы. Генотипирование однонуклеотидных полиморфизмов (SNP) генов сигнального каскада арил-гидрокарбонового рецептора (rs2066853 AHR, rs2292596 AHRR, rs2228099 ARNT, rs1048943 CYP1A1, rs762551 CYP1A2, rs1056836 CYP1B1, rs1800566 NQO1) было проведено методом ПЦР в режиме реального времени. С развитием миомы матки ассоциировались rs2228099 ARNT (OR=1,58; 95%CI=1,19-2,09) и rs1048943 CYP1A1 (OR=0,59; 95%CI=0,40-0,91). A total of 603 females with uterine fibroids and 398 healthy individuals from Central Russia were recruited for the study. Genotyping of single nucleotide polymorphisms (SNPs) of the aryl hydrocarbon receptor signaling pathway genes (rs2066853 AHR, rs2292596 AHRR, rs2228099 ARNT, rs1048943 CYP1A1, rs762551 CYP1A2, rs1056836 CYP1B1, rs1800566 NQO1) were done using Taq-Man-based assays. Polymorphisms rs2228099 ARNT (OR=1,58; 95%CI=1,19-2,09) and rs1048943 CYP1A1 (OR=0,59; 95%CI=0,40-0,91) were associated with predisposition to uterine fibroids.

scholarly journals Impact of Genetic Variability on Physiological Responses to Caffeine in Humans: A Systematic Review

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1373 ◽  
Author(s):  
Jacob Fulton ◽  
Petros Dinas ◽  
Andres Carrillo ◽  
Jason Edsall ◽  
Emily Ryan ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Single Nucleotide Polymorphisms ◽  
Genetic Analysis ◽  
Physiological Responses ◽  
Controlled Trials ◽  
Nucleotide Polymorphisms ◽  
Caffeine Consumption ◽  
Cross Sectional ◽  
Single Nucleotide ◽  
Aryl Hydrocarbon

Emerging research has demonstrated that genetic variation may impact physiological responses to caffeine consumption. The purpose of the present review was to systematically recognize how select single nucleotide polymorphisms (SNPs) impact habitual use of caffeine as well as the ergogenic and anxiogenic consequences of caffeine. Two databases (PubMed and EBSCO) were independently searched using the same algorithm. Selected studies involved human participants and met at least one of the following inclusion criteria: (a) genetic analysis of individuals who habitually consume caffeine; (b) genetic analysis of individuals who underwent measurements of physical performance with the consumption of caffeine; (c) genetic analysis of individuals who underwent measurements of mood with the consumption of caffeine. We included 26 studies (10 randomized controlled trials, five controlled trials, seven cross-sectional studies, three single-group interventional studies and one case-control study). Single nucleotide polymorphisms in or near the cytochrome P450 (CYP1A2) and aryl hydrocarbon receptor (AHR) genes were consistently associated with caffeine consumption. Several studies demonstrated that the anxiogenic consequences of caffeine differed across adenosine 2a receptor (ADORA2A) genotypes, and the studies that investigated the effects of genetic variation on the ergogenic benefit of caffeine reported equivocal findings (CYP1A2) or warrant replication (ADORA2A).

Development of a simple method for the determination of single nucleotide polymorphisms

2010 ◽  
Vol 34 (8) ◽  
pp. S75-S75
Author(s):  
Weifeng Zhu ◽  
Zhuoqi Liu ◽  
Daya Luo ◽  
Xinyao Wu ◽  
Fusheng Wan
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Simple Method ◽  
Single Nucleotide
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