Effects of Blood Flow on the in Vivo Recovery of a Small Diffusible Molecule by Microdialysis in Human Skin

At the micrometric scale, vessels or skin capillaries network architecture can provide useful information for human health management. In this paper, from simulation to in vitro, we investigate some limits and interests of optical feedback interferometry (OFI) for blood flow imaging of skin vascularization. In order to analyze the tissue scattering effect on OFI performances, a series of skin-tissue simulating optical phantoms have been designed, fabricated and characterized. The horizontal (2D) and vertical (depth penetration) sensing resolution of the OFI sensor have been estimated. The experimental results that we present on this study are showing a very good accordance with theoretical models. In the case of a skin phantom of 0.5 mm depth with a scattering coefficient from 0 to 10.8 mm−1, the presented OFI system is able to distinguish a pair of micro fluidic channels (100 µm × 100 µm) spaced by 10 µm. Eventually, an in vivo test on human skin is presented and, for the first time using an OFI sensor, a 2D blood flow image of a vein located just beneath the skin is computed.

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Acute effects of iontophoresis on human skin in vivo: cutaneous blood flow and transepidermal water loss measurements

European Journal of Pharmaceutics and Biopharmaceutics ◽

10.1016/s0939-6411(96)00001-x ◽

1997 ◽

Vol 43 (2) ◽

pp. 133-138 ◽

Cited By ~ 12

Author(s):

Rhonda M. Brand ◽

Parminder Singh ◽

Elena Aspecarranza ◽

Howard I. Maibach ◽

richard H. Guy

Keyword(s):

Blood Flow ◽

Human Skin ◽

Water Loss ◽

Transepidermal Water Loss ◽

Cutaneous Blood Flow ◽

Acute Effects ◽

Cutaneous Blood

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Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood flow

Optics Letters ◽

10.1364/ol.25.001358 ◽

2000 ◽

Vol 25 (18) ◽

pp. 1358 ◽

Cited By ~ 161

Author(s):

Yonghua Zhao ◽

Zhongping Chen ◽

Christopher Saxer ◽

Qimin Shen ◽

Shaohua Xiang ◽

...

Keyword(s):

Blood Flow ◽

Standard Deviation ◽

Human Skin ◽

Skin Blood Flow ◽

Clinical Monitoring

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Microvascular features that suggest effectors of blood-flow regulation in the brain: Evidence by SEM of corrosion casts of intracerebral vessels

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100158923 ◽

1990 ◽

Vol 48 (3) ◽

pp. 274-275

Author(s):

Enrico D.F. Motti ◽

Hans-Georg Imhof ◽

Gazi M. Yasargil

Keyword(s):

Blood Flow ◽

Perfusion Pressure ◽

Corrosion Casts ◽

Cerebral Microcirculation ◽

Pial Arteries ◽

Random Occurrence ◽

Brain Arteries ◽

Homogeneous Network ◽

The Brain

Physiologists have devoted most attention in the cerebrovascular tree to the arterial side of the circulation which has been subdivided in three levels: 1) major brain arteries which keep microcirculation constant despite changes in perfusion pressure; 2) pial arteries supposed to be effectors regulating microcirculation; 3) intracerebral arteries supposed to be deprived of active cerebral blood flow regulating devices.The morphological search for microvascular effectors in the cerebrovascular bed has been elusive. The opaque substance of the brain confines in vivo investigation to the superficial pial arteries. Most morphologists had to limit their observation to the random occurrence of a favorable site in the practically two-dimensional thickness of diaphanized histological sections. It is then not surprising most investigators of the cerebral microcirculation refer to an homogeneous network of microvessels interposed between arterioles and venules.We have taken advantage of the excellent depth of focus afforded by the scanning electron microscope (SEM) to investigate corrosion casts obtained injecting a range of experimental animals with a modified Batson's acrylic mixture.

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