Phenyl N-tert-Butylnitrone Down-Regulates  Interleukin-1β-Stimulated Matrix Metalloproteinase-13 Gene Expression in  Human Chondrocytes: Suppression of c-Jun NH2-Terminal Kinase,  p38-Mitogen-Activated Protein Kinase and Activating Protein-1

Interleukin 1Β ◽

Human Chondrocytes ◽

Matrix Metalloproteinase 13 ◽

In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway

Journal of Neuroinflammation ◽

10.1186/1742-2094-10-107 ◽

2013 ◽

Vol 10 (1) ◽

Cited By ~ 6

Author(s):

Justin A Green ◽

Lucinda Rand ◽

Rachel Moores ◽

Shruti Dholakia ◽

Theodore Pezas ◽

...

Keyword(s):

Gene Expression ◽

Protein Kinase ◽

In Vitro Model ◽

Matrix Metalloproteinase 1 ◽

Vitro Model ◽

Dependent Pathway

Fibronectin fragments and blocking antibodies to ?2?1 and ?5?1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes

Arthritis & Rheumatism ◽

10.1002/art.10502 ◽

2002 ◽

Vol 46 (9) ◽

pp. 2368-2376 ◽

Cited By ~ 126

Author(s):

Christopher B. Forsyth ◽

Judit Pulai ◽

Richard F. Loeser

Keyword(s):

Protein Kinase ◽

Articular Chondrocytes ◽

Human Articular Chondrocytes ◽

Matrix Metalloproteinase 13 ◽

Fibronectin Fragments ◽

Blocking Antibodies ◽

Protein Kinase Signaling

Matrix metalloproteinase 2 (MMP2); MMP9; p38 mitogen-activated protein kinase (p38 MAPK); MAP kinase ERK-1; MAP kinase ERK-2; interleukin-1β (IL-1β)

Science-Business eXchange ◽

10.1038/scibx.2008.96 ◽

2008 ◽

Vol 1 (4) ◽

pp. 96-96

Keyword(s):

Protein Kinase ◽

Map Kinase ◽

P38 Mapk ◽

Interleukin 1Β ◽

Matrix Metalloproteinase 2 ◽

Regulation of Interleukin-1β-induced Interleukin-6 Gene Expression in Human Fibroblast-like Synoviocytes by p38 Mitogen-activated Protein Kinase

Journal of Biological Chemistry ◽

10.1074/jbc.273.38.24832 ◽

1998 ◽

Vol 273 (38) ◽

pp. 24832-24838 ◽

Cited By ~ 165

Author(s):

Keiji Miyazawa ◽

Akio Mori ◽

Hiroshi Miyata ◽

Masuo Akahane ◽

Yukiyoshi Ajisawa ◽

...

Keyword(s):

Gene Expression ◽

Protein Kinase ◽

Interleukin 6 ◽

Human Fibroblast ◽

Interleukin 1Β ◽

Fibroblast Like Synoviocytes

The Mitogen-activated Protein Kinase and JAK-STAT Signaling Pathways Are Required for an Oncostatin M-responsive Element-mediated Activation of Matrix Metalloproteinase 1 Gene Expression

Journal of Biological Chemistry ◽

10.1074/jbc.272.2.1188 ◽

1997 ◽

Vol 272 (2) ◽

pp. 1188-1196 ◽

Cited By ~ 116

Author(s):

Edward Korzus ◽

Hideaki Nagase ◽

Russell Rydell ◽

James Travis

Keyword(s):

Gene Expression ◽

Protein Kinase ◽

Signaling Pathways ◽

Oncostatin M ◽

Matrix Metalloproteinase 1 ◽

Stat Signaling ◽

Responsive Element

Novel p38 mitogen-activated protein kinase inhibitor R-130823 protects cartilage by down-regulating matrix metalloproteinase-1,-13 and prostaglandin E2 production in human chondrocytes

International Immunopharmacology ◽

10.1016/j.intimp.2005.07.009 ◽

2006 ◽

Vol 6 (2) ◽

pp. 144-155 ◽

Cited By ~ 12

Author(s):

Yoshihiro Wada ◽

Kohei Shimada ◽

Kotaro Sugimoto ◽

Tomio Kimura ◽

Shigeru Ushiyama

Keyword(s):

Protein Kinase ◽

Prostaglandin E2 ◽

Kinase Inhibitor ◽

Protein Kinase Inhibitor ◽

Human Chondrocytes ◽

Matrix Metalloproteinase 1 ◽

Faculty Opinions recommendation of Borrelia burgdorferi-induced expression of matrix metalloproteinases from human chondrocytes requires mitogen-activated protein kinase and Janus kinase/signal transducer and activator of transcription signaling pathways.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1019794.225426 ◽

2004 ◽

Author(s):

Timo Korhonen

Keyword(s):

Protein Kinase ◽

Matrix Metalloproteinases ◽

Borrelia Burgdorferi ◽

Signaling Pathways ◽

Janus Kinase ◽

Human Chondrocytes ◽

Signal Transducer ◽

Induced Expression ◽

beta-Adrenergic Agonist Hyperplastic Effect Is Associated with Increased Fibronectin Gene Expression and Not Mitogen-Activated Protein Kinase Modulation in C2C12 Cells

Proceedings of The Society for Experimental Biology and Medicine ◽

10.1046/j.1525-1373.2000.22343.x ◽

2000 ◽

Vol 223 (3) ◽

pp. 302-309 ◽

Cited By ~ 6

Author(s):

Ernest B. Izevbigie ◽

Werner G. Bergen

Keyword(s):

Gene Expression ◽

Protein Kinase ◽

C2c12 Cells ◽

Adrenergic Agonist ◽

Beta Adrenergic ◽

Beta Adrenergic Agonist

1175. Oncolytic Herpes Simplex Virus-1 G207 Induces Cyclooxygenase-2 Gene Expression by Activation of the Mitogen Activated Protein Kinase Pathway

Molecular Therapy ◽

10.1016/s1525-0016(16)41617-5 ◽

2003 ◽

Vol 7 (5) ◽

pp. S454

Keyword(s):

Gene Expression ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Protein Kinase ◽

Herpes Simplex Virus 1 ◽

Oncolytic Herpes Simplex Virus ◽

Simplex Virus ◽

Kinase Pathway

Docosahexaenoic acid downregulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the c-Jun NH2-terminal kinase mitogen-activated protein kinase pathway

Molecular Nutrition & Food Research ◽

10.1002/mnfr.200800112 ◽

2008 ◽

Vol 53 (3) ◽

pp. 341-348 ◽

Cited By ~ 7

Author(s):

Chia-Yang Lu ◽

Chien-Chun Li ◽

Kai-Li Liu ◽

Chong-Kuei Lii ◽

Haw-Wen Chen

Keyword(s):

Gene Expression ◽

Cytochrome P450 ◽

Protein Kinase ◽

Docosahexaenoic Acid ◽

Primary Hepatocytes ◽

Rat Primary Hepatocytes ◽

Kinase Pathway