Tumor Necrosis Factor-α-Induced Cytokine-Induced Neutrophil Chemoattractant-1 (CINC-1) Production by Rat Gastric Epithelial Cells: Role of Reactive Oxygen Species and Nuclear Factor-κB

2004 ◽  
Vol 309 (2) ◽  
pp. 670-676 ◽  
Author(s):  
Osamu Handa ◽  
Yuji Naito ◽  
Tomohisa Takagi ◽  
Makoto Shimozawa ◽  
Satoshi Kokura ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Oxygen Species ◽  
Gastric Epithelial Cells ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Upregulation of CASP9 through NF-κB and Its Target MiR-1276 Contributed to TNFα-Promoted Apoptosis of Cancer Cells Induced by Doxorubicin

2020 ◽  
Vol 21 (7) ◽  
pp. 2290
Author(s):  
Fei Zhou ◽  
Yun Li ◽  
Yisheng Huang ◽  
Jian Wu ◽  
Qinhan Wu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Hepg2 Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Apoptotic Pathway ◽  
Factor Α ◽  
Necrosis Factor

Under some conditions, nuclear factor-κB (NF-κB) has a pro-apoptotic role, but the mechanisms underlying this function remain unclear. This study demonstrated that NF-κB directly binds to CASP9 and miR1276 in tumor necrosis factor α (TNFα)-treated HeLa and HepG2 cells. NF-κB upregulated CASP9 expression, whereas downregulated miR1276 expression in the TNFα-treated cells. The miR1276 repressed CASP9 expression in both cells. As a result, a typical NF-κB-mediated coherent feed-forward loop was formed in the TNFα-treated cells. It was proposed that the NF-κB-mediated loop may contribute to cell apoptosis under certain conditions. This opinion was supported by the following evidence: TNFα promoted the apoptosis of HeLa and HepG2 cells induced by doxorubicin (DOX). CASP9 was significantly upregulated and activated by TNFα in the DOX-induced cells. Moreover, a known inhibitor of CASP9 activation significantly repressed the TNFα promotion of apoptosis induced by DOX. These findings indicate that CASP9 is a new mediator of the NF-κB pro-apoptotic pathway, at least in such conditions. This study therefore provides new insights into the pro-apoptotic role of NF-κB. The results also shed new light on the molecular mechanism underlying TNFα-promotion of cancer cells apoptosis induced by some anticancer drugs such as DOX.

Role of the protein kinase C λ/ι isoform in nuclear factor-κB activation by interleukin-1β or tumor necrosis factor-α: cell type specificities

1999 ◽  
Vol 57 (6) ◽  
pp. 713-720 ◽  
Author(s):  
Giuseppina Bonizzi ◽  
Jacques Piette ◽  
Sonia Schoonbroodt ◽  
Marie-Paule Merville ◽  
Vincent Bours
Keyword(s):  
Protein Kinase C ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Cell Type ◽  
Kinase C ◽  
Factor Α ◽  
Necrosis Factor
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