2,2,2-Trichloroethanol Activates a Nonclassical Potassium Channel in Cerebrovascular Smooth Muscle and Dilates the Middle Cerebral Artery

This study demonstrated the time-dependent changes in postmortem responses of isolated human middle cerebral artery strips to vasodilators. The relaxation induced by prostaglandin (PG) I2 or nitroglycerin remained stable for 24 h postmortem. In arterial strips precontracted with PGF2α, substance P and bradykinin both elicited relaxation that was almost completely abolished by removal of the endothelium. The endothelium-dependent response to both peptides was significantly degraded in strips obtained >12 h postmortem. These results indicate a selective functional or anatomical vulnerability of the vascular endothelium compared with that of the vasodilator mechanisms of the smooth muscle in the postmortem period. However, cerebral arteries isolated from human cadavers within 12 h postmortem should be adequate for studies of both smooth muscle and endothelial reactivity to vasodilators.

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Neurogenic electrical responses of single smooth muscle cells of the dog middle cerebral artery.

Circulation Research ◽

10.1161/01.res.51.6.751 ◽

1982 ◽

Vol 51 (6) ◽

pp. 751-759 ◽

Cited By ~ 25

Author(s):

H Suzuki ◽

S Fujiwara

Keyword(s):

Smooth Muscle ◽

Smooth Muscle Cells ◽

Middle Cerebral Artery ◽

Cerebral Artery ◽

Muscle Cells ◽

Electrical Responses

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Characterisation of smooth muscle ?-Adrenoceptors and of responses to electrical stimulation in the cat isolated perfused middle cerebral artery

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/bf00498823 ◽

1983 ◽

Vol 323 (1) ◽

pp. 24-32 ◽

Cited By ~ 39

Author(s):

I. C. Medgett ◽

S. Z. Langer

Keyword(s):

Smooth Muscle ◽

Electrical Stimulation ◽

Middle Cerebral Artery ◽

Cerebral Artery

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Interstitial cells from rat middle cerebral artery belong to smooth muscle cell type

Journal of Cellular and Molecular Medicine ◽

10.1111/j.1582-4934.2008.00567.x ◽

2009 ◽

Vol 13 (11-12) ◽

pp. 4532-4539 ◽

Cited By ~ 15

Author(s):

Maksym I. Harhun ◽

Kinga Szewczyk ◽

Holger Laux ◽

Sally A. Prestwich ◽

Dmitri V. Gordienko ◽

...

Keyword(s):

Smooth Muscle ◽

Smooth Muscle Cell ◽

Middle Cerebral Artery ◽

Muscle Cell ◽

Cerebral Artery ◽

Interstitial Cells ◽

Cell Type ◽

Muscle Cell Type

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Acute Ultrastructural Changes in the Middle Cerebral Artery Due to the Injury and Ischemia of Surgical Clamping

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/s0317167100025956 ◽

1976 ◽

Vol 3 (1) ◽

pp. 23-27 ◽

Cited By ~ 17

Author(s):

Ronald F. Dodson ◽

Yukio Tagashira ◽

Lena W-F. Chu

Keyword(s):

Smooth Muscle ◽

Middle Cerebral Artery ◽

Cerebral Artery ◽

Arterial Wall ◽

Cerebrovascular Disorders ◽

Cerebral Vessels ◽

Ultrastructural Changes ◽

Surgical Clip ◽

Nerve Bundles ◽

Neurosurgical Treatment

SUMMARY:Ultrastructural changes in the zone of clamping of the middle cerebral artery of the squirrel monkey are described after application of a surgical clip. The experimental model utilized has been widely applied to the study of cerebral ischemia and possibly has relevance to clamps applied to the cerebral vessels during neurosurgical treatment of patients with cerebrovascular disorders.The earliest changes within the arterial wall were found in the smooth muscle (media) and accompanying fasciculi of nerves. Changes within the nerve bundles were sufficiently advanced following 4 hours of vascular clipping to suggest temporary or permanent impairment of neurogenic innervation of the cerebral vessels distal to the trunk of the vessel clipped.

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