scholarly journals Acute Ultrastructural Changes in the Middle Cerebral Artery Due to the Injury and Ischemia of Surgical Clamping

Author(s):  
Ronald F. Dodson ◽  
Yukio Tagashira ◽  
Lena W-F. Chu

SUMMARY:Ultrastructural changes in the zone of clamping of the middle cerebral artery of the squirrel monkey are described after application of a surgical clip. The experimental model utilized has been widely applied to the study of cerebral ischemia and possibly has relevance to clamps applied to the cerebral vessels during neurosurgical treatment of patients with cerebrovascular disorders.The earliest changes within the arterial wall were found in the smooth muscle (media) and accompanying fasciculi of nerves. Changes within the nerve bundles were sufficiently advanced following 4 hours of vascular clipping to suggest temporary or permanent impairment of neurogenic innervation of the cerebral vessels distal to the trunk of the vessel clipped.

1993 ◽  
Vol 13 (2) ◽  
pp. 346-349 ◽  
Author(s):  
Hisashi Onoue ◽  
Nobuyoshi Kaito ◽  
Shogo Tokudome ◽  
Toshiaki Abe ◽  
Koichi Tashibu ◽  
...  

This study demonstrated the time-dependent changes in postmortem responses of isolated human middle cerebral artery strips to vasodilators. The relaxation induced by prostaglandin (PG) I2 or nitroglycerin remained stable for 24 h postmortem. In arterial strips precontracted with PGF2α, substance P and bradykinin both elicited relaxation that was almost completely abolished by removal of the endothelium. The endothelium-dependent response to both peptides was significantly degraded in strips obtained >12 h postmortem. These results indicate a selective functional or anatomical vulnerability of the vascular endothelium compared with that of the vasodilator mechanisms of the smooth muscle in the postmortem period. However, cerebral arteries isolated from human cadavers within 12 h postmortem should be adequate for studies of both smooth muscle and endothelial reactivity to vasodilators.


2009 ◽  
Vol 13 (11-12) ◽  
pp. 4532-4539 ◽  
Author(s):  
Maksym I. Harhun ◽  
Kinga Szewczyk ◽  
Holger Laux ◽  
Sally A. Prestwich ◽  
Dmitri V. Gordienko ◽  
...  

2020 ◽  
Vol 5 (6) ◽  
pp. 88-94
Author(s):  
N. A. Abdullaeva ◽  
◽  
V. I Cherepova ◽  
O. L. Tovazhnyanska ◽  
V. V. Lazurenko

Extragenital pathology during pregnancy and childbirth occupies a leading place in maternal mortality and perinatal pathology. One of the main ways to maintain the health of mother and child is to identify somatic diseases in pregnant women and timely treat them. Nervous system diseases that occur in pregnant women are mainly epilepsy, multiple sclerosis, brain tumors, cerebrovascular disorders, although remain poorly understood, but require immediate decisions to prolong pregnancy, obstetric tactics during childbirth, conservative or conservative surgery. The pathology of cerebral vessels (arterial aneurysms and arteriovenous malformations) also remains an urgent problem, despite many years of experience in their diagnosis and treatment. The sudden development of symptoms, severity of clinical manifestations and high mortality in rupture of an aneurysm or arteriovenous malformation of cerebral vessels determine the urgency of this problem and increased interest in its study, especially in pregnant women. Material and methods. The paper presents a clinical case of arteriovenous malformation in a 25-year-old pregnant woman, her treatment and delivery. Results and discussion. Arteriovenous malformation is considered a congenital cerebrovascular pathology, which is accompanied by a sudden rupture of abnormal vessels with the development of hemorrhagic stroke, without specific clinical symptoms and precursors, which complicates lifelong diagnosis. Endovascular embolization during pregnancy saved the lives of women and children. An effective result was obtained after neurosurgical treatment of arteriovenous malformation in a pregnant woman in the second trimester of pregnancy (17 weeks), which allowed to bring the pregnancy to the physiological time of delivery. Taking into account the complex neurological pathology, neurosurgery, which requires the exclusion of a powerful period of childbirth, a pregnant woman gave birth by cesarean section at 38 weeks of pregnancy. Conclusion. An effective result was obtained after neurosurgical treatment of arteriovenous malformation in a pregnant woman in the second trimester of pregnancy, which allowed to bring the pregnancy to the physiological time of delivery. The obtained results indicated the possibility of full-term pregnancy, reduction of maternal and perinatal morbidity and mortality in pregnant women with arteriovenous malformation with timely preventive and curative measures with timely referral of pregnant women to the perinatal center on the basis of a multidisciplinary clinical institution to prevent complications


2012 ◽  
Vol 689 (1-3) ◽  
pp. 160-164 ◽  
Author(s):  
Anikó Kovács ◽  
László G. Hársing ◽  
Gábor Szénási

2009 ◽  
Vol 332 (3) ◽  
pp. 803-810 ◽  
Author(s):  
Nikhil K. Parelkar ◽  
Neerupma Silswal ◽  
Kirsten Jansen ◽  
Joshua Vaughn ◽  
Robert M. Bryan ◽  
...  

2020 ◽  
Vol 118 (3) ◽  
pp. 261a
Author(s):  
Kelsey C. North ◽  
Luiz Moreira ◽  
Alexandria Slayden ◽  
Anna N. Bukiya ◽  
Alex M. Dopico

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