ADX71743, a Potent and Selective Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7: In Vitro and In Vivo Characterization

Mikhail Kalinichev; Mélanie Rouillier; Francoise Girard; Isabelle Royer-Urios; Bruno Bournique; Terry Finn; Delphine Charvin; Brice Campo; Emmanuel Le Poul; Vincent Mutel; Sonia Poli; Stuart A. Neale; Thomas E. Salt; Robert Lütjens

doi:10.1124/jpet.112.200915

ADX71743, a Potent and Selective Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7: In Vitro and In Vivo Characterization

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.112.200915 ◽

2012 ◽

Vol 344 (3) ◽

pp. 624-636 ◽

Cited By ~ 54

Author(s):

Mikhail Kalinichev ◽

Mélanie Rouillier ◽

Francoise Girard ◽

Isabelle Royer-Urios ◽

Bruno Bournique ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator ◽

In Vivo Characterization

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Correction to “ADX71743, a Potent and Selective Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7: In Vitro and In Vivo Characterization”

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.112.05er13b ◽

2013 ◽

Vol 345 (2) ◽

pp. 328-328

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator ◽

In Vivo Characterization

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In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: Review article

Amino Acids ◽

10.1007/s00726-001-0130-6 ◽

2002 ◽

Vol 23 (1-3) ◽

pp. 207-211 ◽

Cited By ~ 37

Author(s):

R. Kuhn ◽

A. Pagano ◽

N. Stoehr ◽

I. Vranesic ◽

P. J. Flor ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Review Article ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

In Vivo Characterization

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[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine Binding to Metabotropic Glutamate Receptor Subtype 5 in Rodent Brain: In Vitro and in Vivo Characterization

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.102.040618 ◽

2002 ◽

Vol 303 (3) ◽

pp. 1044-1051 ◽

Cited By ~ 83

Author(s):

Jeffery J. Anderson ◽

Sara P. Rao ◽

Blake Rowe ◽

Darlene R. Giracello ◽

Greg Holtz ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Subtype ◽

Metabotropic Glutamate ◽

Rodent Brain ◽

In Vivo Characterization

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In Vitro Functional Characterization of GET73 as Possible Negative Allosteric Modulator of Metabotropic Glutamate Receptor 5

Frontiers in Pharmacology ◽

10.3389/fphar.2018.00327 ◽

2018 ◽

Vol 9 ◽

Cited By ~ 1

Author(s):

Sarah Beggiato ◽

Andrea C. Borelli ◽

Maria C. Tomasini ◽

M. Paola Castelli ◽

Nicholas Pintori ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Functional Characterization ◽

Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator

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VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.115.226597 ◽

2015 ◽

Vol 356 (1) ◽

pp. 123-136 ◽

Cited By ~ 24

Author(s):

H. H. Nickols ◽

J. P. Yuh ◽

K. J. Gregory ◽

R. D. Morrison ◽

B. S. Bates ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

In Vivo Efficacy ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator

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Population Pharmacokinetic and Exposure-dizziness Modeling for a Metabotropic Glutamate Receptor Subtype 5 Negative Allosteric Modulator in Major Depressive Disorder Patients

Clinical and Translational Science ◽

10.1111/cts.12566 ◽

2018 ◽

Vol 11 (5) ◽

pp. 523-531

Author(s):

Valérie Cosson ◽

Franziska Schaedeli-Stark ◽

Mona Arab-Alameddine ◽

Clarisse Chavanne ◽

Elena Guerini ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Population Pharmacokinetic ◽

Receptor Subtype ◽

Allosteric Modulator ◽

Major Depressive ◽

Metabotropic Glutamate ◽

Negative Allosteric Modulator

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Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles

Neuropsychopharmacology ◽

10.1038/npp.2014.245 ◽

2014 ◽

Vol 40 (3) ◽

pp. 755-765 ◽

Cited By ~ 22

Author(s):

Jerri M Rook ◽

Mohammed N Tantawy ◽

Mohammad S Ansari ◽

Andrew S Felts ◽

Shaun R Stauffer ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Receptor Occupancy ◽

Receptor Subtype ◽

Allosteric Modulators ◽

Metabotropic Glutamate ◽

In Vitro Binding ◽

Vitro Binding

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Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator

Psychopharmacology ◽

10.1007/s00213-012-2804-z ◽

2012 ◽

Vol 225 (1) ◽

pp. 151-159 ◽

Cited By ~ 23

Author(s):

Lucas R. Watterson ◽

Peter R. Kufahl ◽

Natali E. Nemirovsky ◽

Kaveish Sewalia ◽

Lauren E. Hood ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Metabotropic Glutamate Receptor 5 ◽

Metabotropic Glutamate ◽

Seeking Behavior ◽

Negative Allosteric Modulator ◽

Food Seeking

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Synthesis, radiolabeling, in vitro and in vivo evaluation of [18F]-FPECMO as a positron emission tomography radioligand for imaging the metabotropic glutamate receptor subtype 5

Nuclear Medicine and Biology ◽

10.1016/j.nucmedbio.2009.03.005 ◽

2009 ◽

Vol 36 (6) ◽

pp. 613-622 ◽

Cited By ~ 14

Author(s):

Christophe Lucatelli ◽

Michael Honer ◽

Jean-Frédéric Salazar ◽

Tobias L. Ross ◽

P. August Schubiger ◽

...

Keyword(s):

Positron Emission Tomography ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Emission Tomography ◽

Receptor Subtype ◽

In Vivo Evaluation ◽

Metabotropic Glutamate ◽

Positron Emission

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Effects of a novel metabotropic glutamate receptor 7 negative allosteric modulator, 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazonolo[4,5-c]pyridin-4(5H)-one (MMPIP), on the central nervous system in rodents

European Journal of Pharmacology ◽

10.1016/j.ejphar.2009.08.047 ◽

2010 ◽

Vol 639 (1-3) ◽

pp. 106-114 ◽

Cited By ~ 25

Author(s):

Hirohiko Hikichi ◽

Takeshi Murai ◽

Shoki Okuda ◽

Shunsuke Maehara ◽

Akio Satow ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Allosteric Modulator ◽

Metabotropic Glutamate ◽

The Central Nervous System ◽

Negative Allosteric Modulator

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