Profound Spinal Tolerance after Repeated Exposure to a Highly Selective μ-Opioid Peptide Agonist: Role of δ-Opioid Receptors

2002 ◽  
Vol 302 (1) ◽  
pp. 188-196 ◽  
Author(s):  
Guo-Min Zhao ◽  
Dunli Wu ◽  
Yi Soong ◽  
Megumi Shimoyama ◽  
Irena Berezowska ◽  
...  
2001 ◽  
Vol 48 (4) ◽  
pp. 1121-1124 ◽  
Author(s):  
A Olma ◽  
N N Chung ◽  
P W Schiller ◽  
J Zabrocki

To evaluate the role of aromatic amino-acids residues, four analogues of the mu-selective opioid peptide agonist DALDA (H-Tyr-D-Arg-Phe-Lys-NH2) containing the amphiphilic, a,a-disubstituted amino acid (R)- or (S)-alpha-hydroxymethyltyrosine (HmTyr) in position 1 and (R)- or (S)-alpha-hydroxymethylphenylalanine (HmPhe) in position 3 of the peptide sequence were synthesized. Only the [(R)-HmPhe3)]DALDA analogue displayed full agonistic activity in both the guinea pig ileum and the mouse vas deferens assays and turned out to be a delta receptor-selective opioid agonist.


2019 ◽  
Vol 844 ◽  
pp. 175-182 ◽  
Author(s):  
Jeremy C. Cornelissen ◽  
Floyd F. Steele ◽  
Rebekah D. Tenney ◽  
Samuel Obeng ◽  
Kenner C. Rice ◽  
...  

2012 ◽  
Vol 67 (5) ◽  
pp. 55-57
Author(s):  
M. A. Cheido ◽  
M. M. Gevorkyan

The study has shown that activation of delta1-opioid receptors by a highly selective peptide agonist DPDPE (100 µg/kg) results in a significant increase of the immune response to antigen (SRBC, 5×108) in CBA mice. SCH-23390 (1 mg/kg), a selective antagonist of the postsynaptic dopamine D1-receptors, and selective D2-blocker haloperidol (1 mg/kg) prevented immunostimulating effect of DPDPE. Comparison of effects of the antagonists suggests that delta1-opioidergic immunostimulation has more significant impact due to involvement of dopamine D1-receptors. 


2002 ◽  
Vol 72 (1-2) ◽  
pp. 93-99 ◽  
Author(s):  
Srinivas Gullapalli ◽  
Kumar V.S. Nemmani ◽  
Poduri Ramarao

Author(s):  
Lena Nadarevic ◽  
Rolf Reber ◽  
Anne Josephine Helmecke ◽  
Dilara Köse

Abstract To better understand the spread of fake news in the Internet age, it is important to uncover the variables that influence the perceived truth of information. Although previous research identified several reliable predictors of truth judgments—such as source credibility, repeated information exposure, and presentation format—little is known about their simultaneous effects. In a series of four experiments, we investigated how the abovementioned factors jointly affect the perceived truth of statements (Experiments 1 and 2) and simulated social media postings (Experiments 3 and 4). Experiment 1 explored the role of source credibility (high vs. low vs. no source information) and presentation format (with vs. without a picture). In Experiments 2 and 3, we additionally manipulated repeated exposure (yes vs. no). Finally, Experiment 4 examined the role of source credibility (high vs. low) and type of repetition (congruent vs. incongruent vs. no repetition) in further detail. In sum, we found no effect of presentation format on truth judgments, but strong, additive effects of source credibility and repetition. Truth judgments were higher for information presented by credible sources than non-credible sources and information without sources. Moreover, congruent (i.e., verbatim) repetition increased perceived truth whereas semantically incongruent repetition decreased perceived truth, irrespectively of the source. Our findings show that people do not rely on a single judgment cue when evaluating a statement’s truth but take source credibility and their meta-cognitive feelings into account.


2017 ◽  
Vol 152 (5) ◽  
pp. S212
Author(s):  
Muriel H. Larauche ◽  
Nabila Moussaoui ◽  
Mandy Biraud ◽  
Won Ki Bae ◽  
Wendy Walwyn ◽  
...  

2017 ◽  
Vol 32 (1) ◽  
pp. 444-451 ◽  
Author(s):  
Adriano Mollica ◽  
Sveva Pelliccia ◽  
Valeria Famiglini ◽  
Azzurra Stefanucci ◽  
Giorgia Macedonio ◽  
...  

2015 ◽  
Vol 35 (35) ◽  
pp. 12217-12231 ◽  
Author(s):  
L. Hipolito ◽  
A. Wilson-Poe ◽  
Y. Campos-Jurado ◽  
E. Zhong ◽  
J. Gonzalez-Romero ◽  
...  

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