scholarly journals Temperature Dependence of the Biophysical Mechanisms Underlying the Inhibition and Enhancement Effect of Amiodarone on hERG Channels

2019 ◽  
Vol 96 (3) ◽  
pp. 330-344 ◽  
Author(s):  
Yung-Chen Lo ◽  
Chung-Chin Kuo
1967 ◽  
Vol 22 (10) ◽  
pp. 1504-1507
Author(s):  
A. Levialdi ◽  
N. Romeo ◽  
G. Saitta

We describe a new method for analyzing the brightness wave which accounts for the temperature-dependence of the secondary peak, provides a different interpretation of the enhancement effect in ac+dc and gives a more detailed analysis of the spectral composition of the different harmonic components.


1983 ◽  
Vol 61 (11) ◽  
pp. 1528-1530 ◽  
Author(s):  
S. M. Raza

Yield stress "anomalies" have been studied in polycrystalline nickel at low temperatures. Both quantum effects and structural changes below 0.1–0.2 of the Debye temperature contribute to low-temperature anomalies in the temperature dependence of the yield stress. The anomalies appear to be basically a consequence of the effect of zero-point vibrations on the rates of transition in the localized process of activation. An attempt is made to explain the anomalies by introducing a "strain-enhancement" effect, i.e., f(T), semiempirically in the logrithmic creep equation [Formula: see text] where Teff = T0 + AT2 (T0 and A are constants), which allows for quantum effects below a certain temperature.


Author(s):  
Kenneth H. Downing ◽  
Robert M. Glaeser

The structural damage of molecules irradiated by electrons is generally considered to occur in two steps. The direct result of inelastic scattering events is the disruption of covalent bonds. Following changes in bond structure, movement of the constituent atoms produces permanent distortions of the molecules. Since at least the second step should show a strong temperature dependence, it was to be expected that cooling a specimen should extend its lifetime in the electron beam. This result has been found in a large number of experiments, but the degree to which cooling the specimen enhances its resistance to radiation damage has been found to vary widely with specimen types.


Author(s):  
Sonoko Tsukahara ◽  
Tadami Taoka ◽  
Hisao Nishizawa

The high voltage Lorentz microscopy was successfully used to observe changes with temperature; of domain structures and metallurgical structures in an iron film set on the hot stage combined with a goniometer. The microscope used was the JEM-1000 EM which was operated with the objective lens current cut off to eliminate the magnetic field in the specimen position. Single crystal films with an (001) plane were prepared by the epitaxial growth of evaporated iron on a cleaved (001) plane of a rocksalt substrate. They had a uniform thickness from 1000 to 7000 Å.The figure shows the temperature dependence of magnetic domain structure with its corresponding deflection pattern and metallurgical structure observed in a 4500 Å iron film. In general, with increase of temperature, the straight domain walls decrease in their width (at 400°C), curve in an iregular shape (600°C) and then vanish (790°C). The ripple structures with cross-tie walls are observed below the Curie temperature.


1981 ◽  
Vol 24 (4) ◽  
pp. 520-525 ◽  
Author(s):  
Bruce L. Plakke ◽  
Daniel J. Orchik ◽  
Daniel S. Beasley

Binaural auditory fusion of 108 children (4, 6, and 8 years old) was studied using three lists of monosyllabic words (WIPI) presented at two sensation levels (30 and 40 dB). The words were processed to produce three bandwidth conditions (100, 300, 600 Hz) and were administered via three presentation modes (binaural fusion 1, diotic, binaural fusion 2). Results showed improved discrimination scores with increasing age, sensation level, and filter bandwidth. Diotic scores were better than binaural fusion scores for the narrower bandwidth conditions, but the diotic enhancement effect was seriously compromised in the widest bandwidth (600 Hz) condition. The results confirmed the contention that prior research results were equivocal due, in large measure, to procedural variability. Methods for reducing such variability and enhancing the clinical viability of binaural fusion tasks are suggested.


2002 ◽  
Vol 12 (3) ◽  
pp. 71-74
Author(s):  
J. A. Jiménez Tejada ◽  
A. Godoy ◽  
A. Palma ◽  
P. Cartujo

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