scholarly journals A commensal strain ofStaphylococcus epidermidisprotects against skin neoplasia

2018 ◽  
Vol 4 (2) ◽  
pp. eaao4502 ◽  
Author(s):  
Teruaki Nakatsuji ◽  
Tiffany H. Chen ◽  
Anna M. Butcher ◽  
Lynnie L. Trzoss ◽  
Sang-Jip Nam ◽  
...  
Keyword(s):  
Commensal Strain ◽  
Skin Neoplasia

scholarly journals Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al.

2019 ◽  
Vol 5 (9) ◽  
pp. eaaw3915
Author(s):  
Stanislav G. Kozmin ◽  
Igor B. Rogozin ◽  
Elizabeth A. Moore ◽  
Mariah Abney ◽  
Roel M. Schaaper ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Staphylococcus Epidermidis ◽  
Recent Article ◽  
Antitumor Activities ◽  
Base Form ◽  
Commensal Strain ◽  
Mutagenic Effects ◽  
Mutagenic Compound ◽  
Skin Neoplasia

A recent article in Science Advances described the striking discovery that the commensal Staphylococcus epidermidis strain MO34 displays antimicrobial and antitumor activities by producing a small molecule, identified as the nucleobase analog 6-N-hydroxylaminopurine (6-HAP). However, in contradiction to the literature, the authors claimed that 6-HAP is nonmutagenic and proposed that the toxic effect of 6-HAP results from its ability to inhibit, in its base form, DNA synthesis. To resolve the discrepancy, we proved by genetic experiments with bacteria and yeast that extracts of MO34 do contain a mutagenic compound whose effects are identical to chemically synthesized 6-HAP. The MO34 extract induced the same mutation spectrum as authentic 6-HAP. Notably, the toxic and mutagenic effects of both synthetic and MO34-derived 6-HAP depended on conversion to the corresponding nucleotide. The nucleobase 6-HAP does not inhibit DNA synthesis in vitro, and we conclude that 6-HAP exerts its biological activity when incorporated into DNA.

scholarly journals Response to Comment on “A commensal strain of Staphylococcus epidermidis protects against skin neoplasia” by Nakatsuji et al.

2019 ◽  
Vol 5 (9) ◽  
pp. eaay5611
Author(s):  
Teruaki Nakatsuji ◽  
William Fenical ◽  
Richard L. Gallo
Keyword(s):  
Staphylococcus Epidermidis ◽  
Model Systems ◽  
Inhibit Tumor Growth ◽  
Antitumor Activities ◽  
In Vitro Techniques ◽  
Commensal Strain ◽  
The Common ◽  
Skin Bacterium ◽  
Skin Neoplasia

Kozmin et al. contend that observations previously reported regarding the antimicrobial and antitumor activities of 6-N-hydroxy aminopurine (6-HAP) were incorrect. Their conclusions rely on poorly characterized reagents and focus strictly on in vitro techniques without validation in relevant mammalian model systems. We are pleased to be able to illuminate the weaknesses in their technical comment. The totality of current results continues to support our original conclusion that a strain of the common human commensal skin bacterium, Staphylococcus epidermidis, produces 6-HAP that can inhibit tumor growth.

scholarly journals Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium

2018 ◽  
Vol 23 (2) ◽  
pp. 169-176.e6 ◽  
Author(s):  
Sicai Zhang ◽  
Francois Lebreton ◽  
Michael J. Mansfield ◽  
Shin-Ichiro Miyashita ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Enterococcus Faecium ◽  
Botulinum Neurotoxin ◽  
Commensal Strain

Identification and characterization of a botulinum neurotoxin–like toxin in a commensal strain of Enterococcus faecium

Toxicon ◽  
2018 ◽  
Vol 156 ◽  
pp. S73
Author(s):  
Michael J. Mansfield ◽  
Sicai Zhang ◽  
Francois Lebreton ◽  
Shin-Ichiro Miyashita ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Enterococcus Faecium ◽  
Botulinum Neurotoxin ◽  
Commensal Strain ◽  
Identification And Characterization

scholarly journals Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa

2017 ◽  
Vol 61 (5) ◽  
Author(s):  
Helena Turano ◽  
Fernando Gomes ◽  
Gesiele A. Barros-Carvalho ◽  
Ralf Lopes ◽  
Louise Cerdeira ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Type A ◽  
Sequence Type ◽  
Open Reading Frames ◽  
Hypothetical Proteins ◽  
Immunity Protein ◽  
Content Type ◽  
Commensal Strain ◽  
Genes Encoding ◽  
Reading Frames

ABSTRACT A novel transposon belonging to the Tn3-like family was identified on the chromosome of a commensal strain of Pseudomonas aeruginosa sequence type 2343 (ET02). Tn6350 is 7,367 bp long and harbors eight open reading frames (ORFs), an ATPase (IS481 family), a transposase (DDE catalytic type), a Tn3 resolvase, three hypothetical proteins, and genes encoding the new pyocin S8 with its immunity protein. We show that pyocin S8 displays activity against carbapenemase-producing P. aeruginosa, including IMP-1, SPM-1, VIM-1, GES-5, and KPC-2 producers.

Multispectral autoflourescence detection of skin neoplasia using steady-state techniques

2019 ◽  
Author(s):  
Alexander Gisbrecht ◽  
Ekaterina Borisova ◽  
Tsanislava Genova-Hristova ◽  
Petranka Troyanpva ◽  
Elmira Pavlova ◽  
...  
Keyword(s):  
Steady State ◽  
Skin Neoplasia

scholarly journals Complete Genome Sequence of Streptococcus agalactiae Serotype III, Multilocus Sequence Type 283 Strain SG-M1

2015 ◽  
Vol 3 (5) ◽  
Author(s):  
Kurosh S. Mehershahi ◽  
Li Yang Hsu ◽  
Tse Hsien Koh ◽  
Swaine L. Chen
Keyword(s):  
Gastrointestinal Tract ◽  
Genome Sequence ◽  
Streptococcus Agalactiae ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Invasive Disease ◽  
Sequence Type ◽  
Human Gastrointestinal Tract ◽  
Commensal Strain ◽  
Group B

Streptococcus agalactiae (group B Streptococcus ) is a common commensal strain in the human gastrointestinal tract that can also cause invasive disease in humans and other animals. We report here the complete genome sequence of S. agalactiae SG-M1, a serotype III, multilocus sequence type 283 strain, isolated from a Singaporean patient suffering from meningitis.

scholarly journals Defining the temporal requirements for Myc in the progression and maintenance of skin neoplasia

Oncogene ◽  
2004 ◽  
Vol 23 (35) ◽  
pp. 5923-5930 ◽  
Author(s):  
Ignacio Flores ◽  
Daniel J Murphy ◽  
Lamorna Brown Swigart ◽  
Ulrike Knies ◽  
Gerard I Evan
Keyword(s):  
Skin Neoplasia

scholarly journals Crosstalk between PARP-1 and NF-κB modulates the promotion of skin neoplasia

Oncogene ◽  
2004 ◽  
Vol 23 (31) ◽  
pp. 5275-5283 ◽  
Author(s):  
David Martín-Oliva ◽  
Francisco O'Valle ◽  
Jose A Muñoz-Gámez ◽  
M Teresa Valenzuela ◽  
M Isabel Nuñez ◽  
...  
Keyword(s):  
Parp 1 ◽  
Skin Neoplasia

Skin neoplasia in small animals 2. Common feline tumours

In Practice ◽  
2006 ◽  
Vol 28 (6) ◽  
pp. 320-325 ◽  
Author(s):  
Sue Murphy
Keyword(s):  
Small Animals ◽  
Skin Neoplasia
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