scholarly journals Long-acting reversible contraception by effervescent microneedle patch

2019 ◽  
Vol 5 (11) ◽  
pp. eaaw8145 ◽  
Author(s):  
Wei Li ◽  
Jie Tang ◽  
Richard N. Terry ◽  
Song Li ◽  
Aurelie Brunie ◽  
...  
Keyword(s):  
Biodegradable Polymer ◽  
Glycolic Acid ◽  
Interstitial Fluid ◽  
Threshold Level ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Human Participants ◽  
Microneedle Patch ◽  
Long Acting

To increase access to long-acting contraception, we developed a reversible contraceptive microneedle patch that is simple-to-administer, slowly releases contraceptive hormone (levonorgestrel) for >1 month, and generates no biohazardous sharps waste. After manually pressing the patch to skin for 1 min, microneedles rapidly separate from the patch within the skin due to effervescence triggered by contact with skin’s interstitial fluid, as demonstrated in rats and human participants. Long-acting contraception is achieved by formulating microneedles with a biodegradable polymer [poly(lactic-co-glycolic) acid] that slowly releases levonorgestrel for ~1 month in vitro. In rats, the patch maintained levonorgestrel concentration above the human contraceptive threshold level for >1 month, and a placebo microneedle patch was well-tolerated in human participants. Women of reproductive age in three continents demonstrated interest in and preference for long-acting contraception by microneedle patch. These studies indicate that an effervescent microneedle patch could facilitate greater access to long-acting contraception.

scholarly journals Knowledge and factors influencing long acting reversible contraceptive use among women of reproductive age in Nigeria

2019 ◽  
Vol 3 ◽  
pp. 7 ◽  
Author(s):  
Obasanjo Afolabi Bolarinwa ◽  
Olalekan Seun Olagunju
Keyword(s):  
Logistic Regression ◽  
Human Error ◽  
Contraceptive Use ◽  
Target Population ◽  
Household Wealth ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Unintended Pregnancies ◽  
Long Acting ◽  
Long Acting Reversible Contraceptive

Background: Over a month when contraception is used, approximately 48% of unintended pregnancies occur as a result of human error, which is largely due to incorrect use, poor adherence and/or technology failure. Long-acting reversible contraceptive (LARC) methods have been developed to bridge this gap because it’s not dependent on compliance with a pill-taking regimen; remembering to change patch or ring; or fixing an appointment with physicians. The main aim of this study is to examine the characteristics of women associated with use of LARC and also to examine the relationship between knowledge of LARC and its current use. Methods: This study assessed the PMA2020 secondary dataset using female datasets from PMA 2016 (Round 3) exercise. PMA 2016 was a survey carried out in seven states of Nigeria. The target population for this study was women of reproductive age (15-49 years) currently using any method of contraception prior to the survey. The weighted sample size of women meeting inclusion criteria in this study is 1927. The data were analyzed using frequency distribution, chi-square and logistic regression. Results: The results showed that 21.0% of women were using traditional methods. Concerning LARC methods, the table showed that 14.8% of the sampled women were using LARC methods. Findings further revealed that at both levels of analysis there is a significant relationship (P<0.05 and P=0.00 for binary and multivariable logistic regression, respectively) between knowledge of LARCs and uses in this study. This means that the use of LARC is being influenced by its knowledge among women of reproductive age in Nigeria. Conclusions: This study concludes that 14.8% of women using any methods of contraceptive were using LARC. Additionally, after controlling for other confounding factors, level of education, age of women, household wealth and number of living children were significantly associated with using LARC.

scholarly journals Knowledge and factors influencing long acting reversible contraceptive use among women of reproductive age in Nigeria

2020 ◽  
Vol 3 ◽  
pp. 7
Author(s):  
Obasanjo Afolabi Bolarinwa ◽  
Olalekan Seun Olagunju
Keyword(s):  
Logistic Regression ◽  
Contraceptive Use ◽  
Target Population ◽  
Household Wealth ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Unintended Pregnancies ◽  
Factors Influencing ◽  
Long Acting ◽  
Long Acting Reversible Contraceptive

Background: Approximately 48% of unintended pregnancies occur as a result of contraceptive failure around the world, which is largely due to incorrect use, poor adherence and/or technology failure. Long-acting reversible contraceptive (LARC) methods have been developed to close this gap because it’s not dependent on compliance with a pill-taking regimen; remembering to change patch or ring; or fixing an appointment with physicians. The main aim of this study is to identify the factors influencing the women associated with use of LARC and to examine the relationship between knowledge of LARC and its current use. Methods: This study assessed the PMA2020 methodology and secondary dataset using female datasets from PMA 2016 (Round 3) exercise. PMA 2016 was a survey carried out in seven states of Nigeria. The target population for this study was women of reproductive age (15-49 years) currently using contraception prior to the survey. The sample size of women meeting inclusion criteria in this study was 1927. The data were analyzed using frequency distribution, chi-square and logistic regression at 5% level of significant. Results: The results showed that 21.0% of women were using traditional methods. Concerning LARC methods, the table showed that 14.8% of the sampled women were using LARC methods. Findings further showed that at both levels of analyses there is a significant relationship (P<0.05 and P=0.00 for binary and multivariable logistic regression, respectively) between knowledge of LARCs and uses in this study. This means that knowledge of LARC & other socio-demographic variables among women of reproductive age in Nigeria can influence the use of it. Conclusions: From the result of the study we concluded that 14.8% of women using contraception were using LARC. Additionally, level of education, age of women, household wealth and number of living children were significantly associated with using LARC.

Perceptions on abortion and long-acting contraceptive use among women of reproductive age in selected Nigerian States: a cross-sectional study

2020 ◽  
Author(s):  
Obasanjo Afolabi Bolarinwa ◽  
Victor Chima ◽  
Olalekan Seun Olagunju
Keyword(s):  
Rural Areas ◽  
Performance Monitoring ◽  
Demographic Factors ◽  
Secondary Data ◽  
Reproductive Age ◽  
P Value ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
Socio Demographic Factors ◽  
Long Acting

Abstract Background: It is estimated that over 210 million pregnancies occur each year, with almost half of these unplanned. The evidence further shows that about 76 million of these unplanned pregnancies occur in the developing world, with 19% ending in induced abortion and 11% of these abortions being unsafe. Abortion is greatly stigmatized in Nigeria, and the lack of a legal framework to support access to abortion services necessitates women seeking abortion services in unsafe places. This study, therefore, examines the perception of women on abortion (prevalence and stigma) on long-acting contraceptive (LARC) use in Nigeria.Methods: We performed secondary data analysis on the round 5 of performance monitoring and accountability (PMA) data for seven states in Nigeria for women of reproductive age (n = 11,284), examining responses on use abortion incidence, perceptions on stigmatization and LARC use using χ2 analysis and multivariate logistic regression models.Results: Socio-demographic factors examined were found to be significantly associated with the perception that abortion was common among women who agreed that abortion was shameful. Women residents in rural areas were more likely (OR = 1.34; p-value = 0.000). Further, married women (OR = 15.18, p-value= 0.000) were 15 times more likely to use LARC.Conclusions: Perceptions that abortion is common, and it is a shameful practice were found to be underlying contributors to LARC use in Nigeria. However, the most significant influence is the socio-demographic factors. Therefore, implementing agencies must ensure to tackle socio-demographic barriers to access and legislation of contraceptive uptake as this would reduce mortality from abortions

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