scholarly journals In silico experiments of bone remodeling explore metabolic diseases and their drug treatment

2020 ◽  
Vol 6 (10) ◽  
pp. eaax0938 ◽  
Author(s):  
Y. Kameo ◽  
Y. Miya ◽  
M. Hayashi ◽  
T. Nakashima ◽  
T. Adachi
Keyword(s):  
Bone Metabolism ◽  
Bone Remodeling ◽  
In Silico ◽  
Bone Structure ◽  
Bone Adaptation ◽  
Bone Diseases ◽  
Therapeutic Effects ◽  
Cellular Interactions ◽  
Metabolic Bone Diseases ◽  
Metabolic Bone

Bone structure and function are maintained by well-regulated bone metabolism and remodeling. Although the underlying molecular and cellular mechanisms are now being understood, physiological and pathological states of bone are still difficult to predict due to the complexity of intercellular signaling. We have now developed a novel in silico experimental platform, V-Bone, to integratively explore bone remodeling by linking complex microscopic molecular/cellular interactions to macroscopic tissue/organ adaptations. Mechano-biochemical couplings modeled in V-Bone relate bone adaptation to mechanical loading and reproduce metabolic bone diseases such as osteoporosis and osteopetrosis. V-Bone also enables in silico perturbation on a specific signaling molecule to observe bone metabolic dynamics over time. We also demonstrate that this platform provides a powerful way to predict in silico therapeutic effects of drugs against metabolic bone diseases. We anticipate that these in silico experiments will substantially accelerate research into bone metabolism and remodeling.

scholarly journals In Silico Experiments to Explore Metabolic Bone Diseases and Their Drug Treatment

2021 ◽  
Vol 61 (3) ◽  
pp. 174-176
Author(s):  
Yoshitaka KAMEO ◽  
Taiji ADACHI
Keyword(s):  
Drug Treatment ◽  
In Silico ◽  
Bone Diseases ◽  
Metabolic Bone Diseases ◽  
Metabolic Bone

scholarly journals Feasibility of Cell Lines for In Vitro Co-Cultures Models for Bone Metabolism

2020 ◽  
Vol 2 (3) ◽  
pp. 157-181 ◽  
Author(s):  
Sabrina Ehnert ◽  
Caren Linnemann ◽  
Romina H. Aspera-Werz ◽  
Victor Häussling ◽  
Bianca Braun ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Ex Vivo ◽  
Treatment Strategies ◽  
In Vitro Models ◽  
Bone Diseases ◽  
Ageing Society ◽  
Metabolic Bone Diseases ◽  
Metabolic Bone

Today, over 70 diseases and health conditions are known that negatively affect the bone quality directly or indirectly by their medical treatment, establishing the term metabolic bone disease. Already every third hospitalized patient in Europe suffers from musculoskeletal injuries or diseases. Facing an ageing society and a more and more sedentary lifestyle the number of chronic diseases and consequently metabolic bone diseases are expected to continuously increase. In order to investigate the various disease constellations and/or develop new treatment strategies suitable models representing bone metabolism are required. Many in vivo, ex vivo and in vitro models have been described, which have their advantages and limits. We here summarize the advantages and challenges of frequently used models to investigate bone metabolism, focusing on in vitro co-cultures of bone forming osteoblasts and osteoclasts. Comparing own data with published models, we further elaborate the feasibility of commonly used cells lines for such in vitro co-culture models, in order to provide an easy, constantly available, and up-scalable model system for screening alterations in bone metabolism.

Design of a Microfluidic System for 3D Culture of Osteocytes In Vitro

2002 ◽  
Author(s):  
Erica Takai ◽  
Clark T. Hung ◽  
Aurea Tucay ◽  
Djordje Djukic ◽  
Mary L. Linde ◽  
...  
Keyword(s):  
Bone Cells ◽  
3D Culture ◽  
Microfluidic System ◽  
Bone Adaptation ◽  
Bone Diseases ◽  
Metabolic Bone Diseases ◽  
Metabolic Bone ◽  
Transduction Mechanisms ◽  
Wolff’S Law

Bone adapts to its mechanical environment so that its form follows function, a mechanism known as Wolff’s law, or bone adaptation. Although the basic concepts of Wolff’s law have been generally accepted, the regulatory signals and the underlying cellular and molecular pathways, which mediate this adaptive process, are unknown. Failure of normal bone adaptation plays a significant role in the etiology of metabolic bone diseases such as osteoporosis and osteopetrosis, bone loss in space flight and failure of total joint replacements. During the past three decades, there have been extensive in vitro studies addressing mechano-signal transduction mechanisms in bone cells including osteoblasts, osteocytes, and osteoclasts [1–8].

scholarly journals FP390A MATHEMATICAL MODEL OF BONE REMODELING IN PATIENTS WITH UREMIA AND METABOLIC BONE DISEASES

2018 ◽  
Vol 33 (suppl_1) ◽  
pp. i165-i166
Author(s):  
Alhaji Cherif ◽  
Priscila Preciado ◽  
Vaibhav Maheshwari ◽  
Doris Fuertinger ◽  
Gudrun Schappacher-Tilp ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Bone Remodeling ◽  
Bone Diseases ◽  
Metabolic Bone Diseases ◽  
Metabolic Bone

scholarly journals H2S Donor and Bone Metabolism

2021 ◽  
Vol 12 ◽  
Author(s):  
Yanming Hao ◽  
Hongzhen Wang ◽  
Lingna Fang ◽  
Jinsong Bian ◽  
Yan Gao ◽  
...  
Keyword(s):  
Side Effects ◽  
Bone Metabolism ◽  
Metabolic Diseases ◽  
Biological Effects ◽  
Bone Diseases ◽  
The Body ◽  
Metabolic Bone Diseases ◽  
Physiological Processes ◽  
Metabolic Bone ◽  
And Function

Hydrogen sulfide (H2S) has been recognized as the third gasotransmitter, following nitric oxide and carbon monoxide, and it exerts important biological effects in the body. Growing evidence has shown that H2S is involved in many physiological processes in the body. In recent years, much research has been carried out on the role of H2S in bone metabolism. Bone metabolic diseases have been linked to abnormal endogenous H2S functions and metabolism. It has been found that H2S plays an important role in the regulation of bone diseases such as osteoporosis and osteoarthritis. Regulation of H2S on bone metabolism has many interacting signaling pathways at the molecular level, which play an important role in bone formation and absorption. H2S releasing agents (donors) have achieved significant effects in the treatment of metabolic bone diseases such as osteoporosis and osteoarthritis. In addition, H2S donors and related drugs have been widely used as research tools in basic biomedical research and may be explored as potential therapeutic agents in the future. Donors are used to study the mechanism and function of H2S as they release H2S through different mechanisms. Although H2S releasers have biological activity, their function can be inconsistent. Additionally, donors have different H2S release capabilities, which could lead to different effects. Side effects may form with the formation of H2S; however, it is unclear whether these side effects affect the biological effects of H2S. Therefore, it is necessary to study H2S donors in detail. In this review, we summarize the current information about H2S donors related to bone metabolism diseases and discuss some mechanisms and biological applications.

Sign in / Sign up

Export Citation Format

Share Document