Differential recognition of oligomannose isomers by glycan-binding proteins involved in innate and adaptive immunity

The recognition of oligomannose-type glycans in innate and adaptive immunity is elusive due to multiple closely related isomeric glycan structures. To explore the functions of oligomannoses, we developed a multifaceted approach combining mass spectrometry assignments of oligomannose substructures and the development of a comprehensive oligomannose microarray. This defined microarray encompasses both linear and branched glycans, varying in linkages, branching patterns, and phosphorylation status. With this resource, we identified unique recognition of oligomannose motifs by innate immune receptors, including DC-SIGN, L-SIGN, Dectin-2, and Langerin, broadly neutralizing antibodies against HIV gp120, N-acetylglucosamine-1-phosphotransferase, and the bacterial adhesin FimH. The results demonstrate that each protein exhibits a unique specificity to oligomannose motifs and suggest the potential to rationally design inhibitors to selectively block these protein-glycan interactions.

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Rational design of HIV gp120 immunogen to induce broadly neutralizing antibodies

Science-Business eXchange ◽

10.1038/scibx.2013.377 ◽

2013 ◽

Vol 6 (15) ◽

pp. 377-377

Keyword(s):

Neutralizing Antibodies ◽

Rational Design ◽

Broadly Neutralizing Antibodies ◽

Hiv Gp120

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NOD1 and NOD2 receptors: integral members of the innate and adaptive immunity system.

Acta Biochimica Polonica ◽

10.18388/abp.2013_1992 ◽

2013 ◽

Vol 60 (3) ◽

Cited By ~ 8

Author(s):

Halina Antosz ◽

Magdalena Osiak

Keyword(s):

Immune System ◽

Signaling Pathways ◽

Adaptive Immunity ◽

Innate Immune System ◽

Inflammatory Diseases ◽

Innate Immune ◽

Inflammatory Signaling ◽

Innate And Adaptive Immunity ◽

Essential Component

NOD-like proteins (NLR) are a specialized group of intracellular receptors, which constitute an essential component of the host innate immune system. They were discovered more than a decade ago, but research on this particular class of microbial detectors is still ongoing to allow for a better understanding of the mechanisms, recognition of microorganisms, transmission of signals, and carrying out the activation of inflammatory signaling pathways. In this review, we discuss the construction of NOD1 and NOD2 receptors, their functions, and significance in the pathogenesis of inflammatory diseases in humans.

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Innate and Adaptive Immunity in Fish: A Review

Al-Anbar Journal of Veterinary Sciences ◽

10.37940/ajvs.2020.13.2.1 ◽

2020 ◽

Vol 13 (2) ◽

Author(s):

Enas Mustafa ◽

Shahbaa AL-Taee

Keyword(s):

Immune System ◽

Adaptive Immunity ◽

Immune Status ◽

Acute Phase Protein ◽

Head Kidney ◽

Innate Immune ◽

High Vertebrate ◽

Innate And Adaptive Immunity ◽

Specific Memory ◽

Hematopoietic Organs

The fish inhabitant in an aquatic environment so it persists exposure to pathogen and stressor factors so they have a developing immune system similar to that in high vertebrate with some differences points. Head Kidney considered the main and primary hematopoietic organs while spleen, thymus and gut-associated lymphoid tissue represented secondary hematopoietic organs. The immune system divided to the innate immune system doesn’t have a memory of previous responses, non-specific cellular as natural killer cells, dendritic cells, neutrophils, basophils and eosinophils with non-specific component these involve complement, lysosomes and acute-phase protein, if the pathogen persists the specific, memory adaptive immunity would be stimulation which composed of two subunits humeral and natural antibodies act for invading extracellular pathogen and the second subunits which are cytokines and T-lymphocyte act for kill intracellular bacterial, parasitic and viral infection. Both subunits (innate and adaptive) of the immune system act each together in the hosts to prevent microorganism’s infection and reducer the environmental stressors and give fish immune status. It is concluded from this article review that fish, like mammalians, have an advanced immune system that plays a role in fish resistance to pathological factors and maintaining fish health.

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Expression of complete SIV p27 Gag and HIV gp120 engineered outer domains targeted by broadly neutralizing antibodies in live rubella vectors

Vaccine ◽

10.1016/j.vaccine.2017.04.047 ◽

2017 ◽

Vol 35 (24) ◽

pp. 3272-3278 ◽

Cited By ~ 4

Author(s):

Konstantin Virnik ◽

Edmund Nesti ◽

Cody Dail ◽

Max Hockenbury ◽

Yisheng Ni ◽

...

Keyword(s):

Neutralizing Antibodies ◽

Broadly Neutralizing Antibodies ◽

Hiv Gp120

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THE CHARACTER OF SYSTEMIC CHANGES IN ADAPTIVE AND INNATE IMMUNE RESPONSE IN PATIENTS WITH MULTIPLE SCLEROSIS

Medical academic journal ◽

10.17816/maj191s158-60 ◽

2019 ◽

Vol 19 (1S) ◽

pp. 58-60

Author(s):

I I Andreeva ◽

L P Sizyakina ◽

Z A Goncharova

Keyword(s):

Multiple Sclerosis ◽

Immune Response ◽

Adaptive Immunity ◽

Innate Immune Response ◽

Clinical Remission ◽

Comprehensive Analysis ◽

Innate Immune ◽

Innate And Adaptive Immunity ◽

Remitting Multiple Sclerosis

The article presents the results of a comprehensive analysis of the parameters of innate and adaptive immunity in 85 patients with recurrent remitting multiple sclerosis (MS) with its exacerbation (54 people) and in conditions of persistent clinical remission (31 people). It is shown the signs of autoinflammation and increased reactivity of the T-link of adaptive immunity to be registered not only in exacerbation, but also in remission. The revealed changes determine the pathogenetic basis of MS progression and they should be taken into account when accompanying patients in remission to prevent clinical activation.

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