CELL SIGNALING: Nuclear Actin as Choreographer of Cell Morphology and Transcription

Science ◽  
2007 ◽  
Vol 316 (5832) ◽  
pp. 1710-1711 ◽  
Author(s):  
J. I. Wu ◽  
G. R. Crabtee
Keyword(s):  
Cell Signaling ◽  
Cell Morphology ◽  
Nuclear Actin

scholarly journals The Use of Nanomedicine to Target Signaling by the PAK Kinases for Disease Treatment

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3565
Author(s):  
Yiling Wang ◽  
Audrey Minden
Keyword(s):  
Drug Delivery ◽  
Cell Signaling ◽  
Cell Survival ◽  
Cell Morphology ◽  
Metabolic Stability ◽  
New Method ◽  
Proliferation Inhibition ◽  
Disease Treatment ◽  
Medical Disorders ◽  
Threonine Kinases

P21-activated kinases (PAKs) are serine/threonine kinases involved in the regulation of cell survival, proliferation, inhibition of apoptosis, and the regulation of cell morphology. Some members of the PAK family are highly expressed in several types of cancer, and they have also been implicated in several other medical disorders. They are thus considered to be good targets for treatment of cancer and other diseases. Although there are several inhibitors of the PAKs, the utility of some of these inhibitors is reduced for several reasons, including limited metabolic stability. One way to overcome this problem is the use of nanoparticles, which have the potential to increase drug delivery. The overall goals of this review are to describe the roles for PAK kinases in cell signaling and disease, and to describe how the use of nanomedicine is a promising new method for administering PAK inhibitors for the purpose of disease treatment and research. We discuss some of the basic mechanisms behind nanomedicine technology, and we then describe how these techniques are being used to package and deliver PAK inhibitors.

Cell morphology, volume, and surface area determinations from multilevel contouring within HVEM micrographs of serial sections and whole-cell mounts

1987 ◽  
Vol 45 ◽  
pp. 588-589
Author(s):  
M. Marko ◽  
A. Leith ◽  
D. Parsons
Keyword(s):  
Surface Area ◽  
Electron Micrographs ◽  
Cell Morphology ◽  
Individual Variation ◽  
Serial Section ◽  
Stereo Pair ◽  
Complex Structures ◽  
Serial Sections ◽  
Surface Areas ◽  
Computer Based

The use of serial sections and computer-based 3-D reconstruction techniques affords an opportunity not only to visualize the shape and distribution of the structures being studied, but also to determine their volumes and surface areas. Up until now, this has been done using serial ultrathin sections.The serial-section approach differs from the stereo logical methods of Weibel in that it is based on the Information from a set of single, complete cells (or organelles) rather than on a random 2-dimensional sampling of a population of cells. Because of this, it can more easily provide absolute values of volume and surface area, especially for highly-complex structures. It also allows study of individual variation among the cells, and study of structures which occur only infrequently.We have developed a system for 3-D reconstruction of objects from stereo-pair electron micrographs of thick specimens.

Sign in / Sign up

Export Citation Format

Share Document