scholarly journals The Use of Nanomedicine to Target Signaling by the PAK Kinases for Disease Treatment

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3565
Author(s):  
Yiling Wang ◽  
Audrey Minden
Keyword(s):  
Drug Delivery ◽  
Cell Signaling ◽  
Cell Survival ◽  
Cell Morphology ◽  
Metabolic Stability ◽  
New Method ◽  
Proliferation Inhibition ◽  
Disease Treatment ◽  
Medical Disorders ◽  
Threonine Kinases

P21-activated kinases (PAKs) are serine/threonine kinases involved in the regulation of cell survival, proliferation, inhibition of apoptosis, and the regulation of cell morphology. Some members of the PAK family are highly expressed in several types of cancer, and they have also been implicated in several other medical disorders. They are thus considered to be good targets for treatment of cancer and other diseases. Although there are several inhibitors of the PAKs, the utility of some of these inhibitors is reduced for several reasons, including limited metabolic stability. One way to overcome this problem is the use of nanoparticles, which have the potential to increase drug delivery. The overall goals of this review are to describe the roles for PAK kinases in cell signaling and disease, and to describe how the use of nanomedicine is a promising new method for administering PAK inhibitors for the purpose of disease treatment and research. We discuss some of the basic mechanisms behind nanomedicine technology, and we then describe how these techniques are being used to package and deliver PAK inhibitors.

scholarly journals MOF Decomposition and Introduction of Repairable Defects Using a Photodegradable Strut

2018 ◽  
Author(s):  
Jingjing Yan ◽  
John MacDonald ◽  
Shawn Burdette
Keyword(s):  
Drug Delivery ◽  
Porous Materials ◽  
New Method ◽  
Innovative Approach ◽  
Partial Decomposition ◽  
Multiple Defects ◽  
Potential Applications ◽  
Defect Repair ◽  
First Time ◽  
Interesting Area

Utilizing a photolabile ligand as MOF strut can make a framework undergo full or partial decomposition upon irradiation. For the first time, a nitrophenylacetate derivative has been incorporated into MOF as a backbone linker via PLSE method. The photo-induced decarboxylation of the NPDAC-MOF represents a novel way of degrading a MOF, which provides an innovative approach to formulating photoresponsive porous materials with potential applications in molecular release and drug delivery. When photoactive linker is mixed with non-photolabile linker via partial PLSE, the MOF structure can be retained after irradiation, but with the introduction of multiple defects, offering a new method to create vacancies in MOFs. Defect repair can be achieved by treatment with replacement ligands, the scope of which is an interesting area for developing customizable MOF contents.<br>

CELL SIGNALING: Nuclear Actin as Choreographer of Cell Morphology and Transcription

Science ◽  
2007 ◽  
Vol 316 (5832) ◽  
pp. 1710-1711 ◽  
Author(s):  
J. I. Wu ◽  
G. R. Crabtee
Keyword(s):  
Cell Signaling ◽  
Cell Morphology ◽  
Nuclear Actin

scholarly journals Chemically modified inulin for intestinal drug delivery – A new dual bioactivity concept for inflammatory bowel disease treatment

2021 ◽  
Vol 252 ◽  
pp. 117091
Author(s):  
Barbara Hufnagel ◽  
Verena Muellner ◽  
Katharina Hlatky ◽  
Claudia Tallian ◽  
Robert Vielnascher ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Treatment ◽  
Chemically Modified ◽  
Inflammatory Bowel

scholarly journals Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment

2020 ◽  
Vol 11 (44) ◽  
pp. 6988-7008 ◽  
Author(s):  
Duc Dung Nguyen ◽  
Jui-Yang Lai
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Disease Treatment ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Stimuli Response

Recent exploitations of stimuli-responsive polymers as ophthalmic drug delivery systems for the treatment of eye diseases are summarized and discussed.

An Overview on Genistein and its Various Formulations

Drug Research ◽  
2018 ◽  
Vol 69 (06) ◽  
pp. 305-313 ◽  
Author(s):  
Neha Jaiswal ◽  
Juber Akhtar ◽  
Satya Prakash Singh ◽  
Farogh Ahsan ◽  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cell Proliferation ◽  
Tumor Cell ◽  
Cancer Cells ◽  
Lower Risk ◽  
Ayurvedic Medicine ◽  
Pharmacological Properties ◽  
Proliferation Inhibition ◽  
Cell Proliferation Inhibition

AbstractGenistein is the natural isoflavone and a phytoestrogen with a broad range of pharmacological properties, such as tyrosine and topoisomerase inhibition. It also induces apoptosis and cell proliferation inhibition, differentiates cancer cells. Added health benefits include the reduction of osteoporosis by suppressing osteoclasts and lymphocyte functions, decreased the risk of cardiovascular attacks and relieved postmenopausal problems. Genistein traditionally used in Chinese and Ayurvedic medicine and are found to be associated with lower risk of breast, prostate and lung cancer. Numerous factors comprising genetic, epigenetic and transcriptomic alterations are evidenced to be responsible for breast, prostate and lung cancer. In present review, an overview on genistein, the various analytical methods and drug delivery approaches to determine genistein in the formulations are discussed. It may help to develop novel formulations with better solubility and bioavailability of genistein. The tumor cell scan may be targeted to form a stable genistein formulation.

miR-199a-3p Inhibitor Delivered Through Nano-Drug Delivery Systems Suppresses Tumor Cell Survival and Metastasis

2020 ◽  
Vol 12 (12) ◽  
pp. 1438-1444
Author(s):  
Erli Wang ◽  
Gang Zhai ◽  
Kaiqing Guo ◽  
Baoping Jiao ◽  
Yi Jia
Keyword(s):  
Drug Delivery ◽  
Cell Survival ◽  
Drug Delivery Systems ◽  
Glycolic Acid ◽  
Opposite Effect ◽  
Plga Nanoparticles ◽  
Potential Treatment ◽  
Nano Drug Delivery ◽  
Life Threatening ◽  
Scanning Electron

Gastric cancer (GC) is a life-threatening malignant tumor present in the digestive tract. In this study the connection of miR-199a-3p, which is a gene abnormally expressed in GC, was analyzed along with the pathological parameters as well as the prognosis of GC patients. Moreover, the influence of miR-199a-3p inhibitor delivered through the nano-drug delivery system (NDDS) was studied in regard of GC cell survival and metastasis, seeking to reveal its potential treatment effect. During the conduction of the study, high miR-199a-3p expression was detected in GC tissues, sera, and cells along with its value for GC screening and pathological progression. In molecular research, polylactic-glycolic acid (PLGA) nanoparticles (NPs)-miRNA complexes that shaped like symmetrical spheres under the scanning electron microscope (SEM) were prepared to increase or decrease the levels of miR-199a-3p. The GC cell survival and metastasis was remarkably facilitated by the elevated miR-199a-3p, and its knockdown produced an opposite effect to markedly inhibit GC cell survival and metastasis. In conclusion, the expression in GC patients was increased by miR-199a-3p and the ability of its inhibitor delivered through the NDDS was demonstrated to control the survival and metastasis of GC cells.

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