scholarly journals Resident memory CD8 T cells trigger protective innate and adaptive immune responses

Science ◽  
2014 ◽  
Vol 346 (6205) ◽  
pp. 98-101 ◽  
Author(s):  
Jason M. Schenkel ◽  
Kathryn A. Fraser ◽  
Lalit K. Beura ◽  
Kristen E. Pauken ◽  
Vaiva Vezys ◽  
...  
Keyword(s):  
T Cells ◽  
Immune Responses ◽  
Viral Infection ◽  
Cd8 T Cells ◽  
Viral Infections ◽  
Innate Immune ◽  
Memory Cd8 T Cells ◽  
Recognition Theory ◽  
Humoral Responses ◽  
Sterilizing Immunity

The pathogen recognition theory dictates that, upon viral infection, the innate immune system first detects microbial products and then responds by providing instructions to adaptive CD8 T cells. Here, we show in mice that tissue resident memory CD8 T cells (TRMcells), non-recirculating cells located at common sites of infection, can achieve near-sterilizing immunity against viral infections by reversing this flow of information. Upon antigen resensitization within the mouse female reproductive mucosae, CD8+TRMcells secrete cytokines that trigger rapid adaptive and innate immune responses, including local humoral responses, maturation of local dendritic cells, and activation of natural killer cells. This provided near-sterilizing immunity against an antigenically unrelated viral infection. Thus, CD8+TRMcells rapidly trigger an antiviral state by amplifying receptor-derived signals from previously encountered pathogens.

scholarly journals The chromatin accessibility signature of human immune aging stems from CD8+ T cells

2017 ◽  
Vol 214 (10) ◽  
pp. 3123-3144 ◽  
Author(s):  
Duygu Ucar ◽  
Eladio J. Márquez ◽  
Cheng-Han Chung ◽  
Radu Marches ◽  
Robert J. Rossi ◽  
...  
Keyword(s):  
T Cells ◽  
Immune Responses ◽  
Cd8 T Cells ◽  
Chromatin Accessibility ◽  
T Cell Signaling ◽  
Memory Cd8 T Cells ◽  
Systems Immunology ◽  
Human Immune ◽  
Chromatin Opening ◽  
Il7r Gene

Aging is linked to deficiencies in immune responses and increased systemic inflammation. To unravel the regulatory programs behind these changes, we applied systems immunology approaches and profiled chromatin accessibility and the transcriptome in PBMCs and purified monocytes, B cells, and T cells. Analysis of samples from 77 young and elderly donors revealed a novel and robust aging signature in PBMCs, with simultaneous systematic chromatin closing at promoters and enhancers associated with T cell signaling and a potentially stochastic chromatin opening mostly found at quiescent and repressed sites. Combined analyses of chromatin accessibility and the transcriptome uncovered immune molecules activated/inactivated with aging and identified the silencing of the IL7R gene and the IL-7 signaling pathway genes as potential biomarkers. This signature is borne by memory CD8+ T cells, which exhibited an aging-related loss in binding of NF-κB and STAT factors. Thus, our study provides a unique and comprehensive approach to identifying candidate biomarkers and provides mechanistic insights into aging-associated immunodeficiency.

scholarly journals The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

Cell Reports ◽  
2020 ◽  
Vol 31 (13) ◽  
pp. 107827 ◽  
Author(s):  
Kristen E. Pauken ◽  
Jernej Godec ◽  
Pamela M. Odorizzi ◽  
Keturah E. Brown ◽  
Kathleen B. Yates ◽  
...  
Keyword(s):  
T Cells ◽  
Viral Infection ◽  
Cd8 T Cells ◽  
Respiratory Viral Infection ◽  
Memory Cd8 T Cells ◽  
And Function

scholarly journals Cutting Edge: Transcription Factor BCL6 Is Required for the Generation, but Not Maintenance, of Memory CD8+ T Cells in Acute Viral Infection

2019 ◽  
Vol 203 (2) ◽  
pp. 323-327 ◽  
Author(s):  
Zhenyu Liu ◽  
Yanyan Guo ◽  
Shupei Tang ◽  
Lan Zhou ◽  
Chunji Huang ◽  
...  
Keyword(s):  
T Cells ◽  
Transcription Factor ◽  
Viral Infection ◽  
Cd8 T Cells ◽  
Cutting Edge ◽  
Memory Cd8 T Cells ◽  
Acute Viral Infection

scholarly journals Antigen-induced but not innate memory CD8 T cells express NKG2D and are recruited to the lung parenchyma upon viral infection

2017 ◽  
Author(s):  
Morgan Grau ◽  
Séverine Valsesia ◽  
Julien Mafille ◽  
Sophia Djebali ◽  
Martine Tomkowiak ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
Viral Infection ◽  
Cd8 T Cells ◽  
Lung Parenchyma ◽  
Surface Expression ◽  
Comprehensive Analysis ◽  
Memory Cells ◽  
Memory Cd8 T Cells ◽  
Memory Phenotype

AbstractThe pool of memory-phenotype CD8 T cells is composed of antigen-induced (AI) and cytokine-induced innate (IN) cells. IN have been described as having similar properties to AI memory cells. However, we found that pathogen-induced AI memory cells can be distinguished from naturally-generated IN memory cells by surface expression of NKG2D. Using this marker, we described the increased functionalities of AI and IN memory CD8 T cells compared to naive cells, as shown by comprehensive analysis of cytokine secretion and gene expression. However, AI differed from IN memory CD8 T cells by their capacity to migrate to the lung parenchyma upon inflammation or infection, a process dependent on their expression of ITGA1/CD49a and ITGA4/CD49d integrins.

scholarly journals 62: Sensing and Alarm Function of Mucosal Memory CD8 T Cells Trigger Innate and Adaptive Immune Responses

2015 ◽  
Vol 143 (suppl_1) ◽  
pp. A034-A034 ◽  
Author(s):  
Jason M. Schenkel ◽  
Kathryn A. Fraser ◽  
Lalit K. Beura ◽  
Kristen E. Pauken ◽  
David Masopust ◽  
...  
Keyword(s):  
T Cells ◽  
Immune Responses ◽  
Cd8 T Cells ◽  
Adaptive Immune Responses ◽  
Memory Cd8 T Cells ◽  
Adaptive Immune
Sign in / Sign up

Export Citation Format

Share Document