Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa

Science ◽  
1994 ◽  
Vol 265 (5168) ◽  
pp. 92-95 ◽  
Author(s):  
T Henkel ◽  
P. Ling ◽  
S. Hayward ◽  
M. Peterson
Keyword(s):  
Epstein Barr Virus ◽  
Binding Protein ◽  
Recombination Signal ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Upregulation of special AT-rich-binding protein 1 by Epstein–Barr virus latent membrane protein 1 in human nasopharyngeal cells and nasopharyngeal cancer

2013 ◽  
Vol 94 (3) ◽  
pp. 507-513 ◽  
Author(s):  
Kazuhira Endo ◽  
Julia Shackelford ◽  
Mitsuharu Aga ◽  
Tomokazu Yoshizaki ◽  
Joseph S. Pagano
Keyword(s):  
Membrane Protein ◽  
Epstein Barr Virus ◽  
Binding Protein ◽  
Nasopharyngeal Cancer ◽  
Latent Membrane Protein ◽  
Latent Membrane Protein 1 ◽  
Tissue Samples ◽  
Multifunctional Protein ◽  
Barr Virus ◽  
Epstein Barr

A global regulator of chromatin remodelling and gene expression, special AT-rich-binding protein 1 (SATB1) has been implicated in promotion of growth and metastasis of a number of cancers. Here, we demonstrate that the principal oncogene of Epstein–Barr virus (EBV), latent membrane protein 1 (LMP1) upregulates SATB1 RNA and protein expression in human nasopharyngeal cell lines. Silencing of endogenously expressed SATB1 with specific short hairpin RNA decreases cell proliferation and resistance to apoptosis induced by growth factor withdrawal. Additionally, we provide evidence that LMP1-mediated expression of Survivin, a multifunctional protein involved in promoting cell growth and survival, is mediated at least in part by SATB1 in human nasopharyngeal cells. Finally, we show that SATB1 protein levels are elevated in tissue samples from patients with nasopharyngeal carcinoma (NPC), and are directly correlated with the expression of LMP1. Taken together, our results suggest that SATB1 functions as a pro-metastatic effector of LMP1 signalling in EBV-positive NPC.

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