scholarly journals Adrenergic nerves activate an angio-metabolic switch in prostate cancer

Science ◽  
2017 ◽  
Vol 358 (6361) ◽  
pp. 321-326 ◽  
Author(s):  
Ali H. Zahalka ◽  
Anna Arnal-Estapé ◽  
Maria Maryanovich ◽  
Fumio Nakahara ◽  
Cristian D. Cruz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Adrenergic Nerves ◽  
Metabolic Switch

scholarly journals CDK9 Inhibition Induces a Metabolic Switch that Renders Prostate Cancer Cells Dependent on Fatty Acid Oxidation

Neoplasia ◽  
2019 ◽  
Vol 21 (7) ◽  
pp. 713-720 ◽  
Author(s):  
Harri M. Itkonen ◽  
Ninu Poulose ◽  
Suzanne Walker ◽  
Ian G. Mills
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Cancer Cells ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Prostate Cancer Cells ◽  
Metabolic Switch

scholarly journals Abstract 1821: Sympathetic nerves regulate a metabolic switch promoting angiogenesis through adrenergic signaling in prostate cancer

2017 ◽  
Author(s):  
Ali Zahalka ◽  
Anna Arnal-Estape ◽  
Maria Maryanovich ◽  
Fumio Nakahara ◽  
Cristian Cruz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Sympathetic Nerves ◽  
Metabolic Switch ◽  
Adrenergic Signaling

scholarly journals Adrenergic Nerves May Promote Angiogenesis in Prostate Cancer

2017 ◽  
Vol 7 (12) ◽  
pp. 1366.2-1366 ◽  
Keyword(s):  
Prostate Cancer ◽  
Adrenergic Nerves

scholarly journals Lysine 53 Acetylation of Cytochrome c in Prostate Cancer: Warburg Metabolism and Evasion of Apoptosis

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 802
Author(s):  
Viktoriia Bazylianska ◽  
Hasini A. Kalpage ◽  
Junmei Wan ◽  
Asmita Vaishnav ◽  
Gargi Mahapatra ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cytochrome C ◽  
Warburg Effect ◽  
Structural Features ◽  
Intrinsic Apoptosis ◽  
Metabolic Switch ◽  
Cancer Hallmarks ◽  
Dynamics Simulations ◽  
The Warburg Effect

Prostate cancer is the second leading cause of cancer-related death in men. Two classic cancer hallmarks are a metabolic switch from oxidative phosphorylation (OxPhos) to glycolysis, known as the Warburg effect, and resistance to cell death. Cytochrome c (Cytc) is at the intersection of both pathways, as it is essential for electron transport in mitochondrial respiration and a trigger of intrinsic apoptosis when released from the mitochondria. However, its functional role in cancer has never been studied. Our data show that Cytc is acetylated on lysine 53 in both androgen hormone-resistant and -sensitive human prostate cancer xenografts. To characterize the functional effects of K53 modification in vitro, K53 was mutated to acetylmimetic glutamine (K53Q), and to arginine (K53R) and isoleucine (K53I) as controls. Cytochrome c oxidase (COX) activity analyzed with purified Cytc variants showed reduced oxygen consumption with acetylmimetic Cytc compared to the non-acetylated Cytc (WT), supporting the Warburg effect. In contrast to WT, K53Q Cytc had significantly lower caspase-3 activity, suggesting that modification of Cytc K53 helps cancer cells evade apoptosis. Cardiolipin peroxidase activity, which is another proapoptotic function of the protein, was lower in acetylmimetic Cytc. Acetylmimetic Cytc also had a higher capacity to scavenge reactive oxygen species (ROS), another pro-survival feature. We discuss our experimental results in light of structural features of K53Q Cytc, which we crystallized at a resolution of 1.31 Å, together with molecular dynamics simulations. In conclusion, we propose that K53 acetylation of Cytc affects two hallmarks of cancer by regulating respiration and apoptosis in prostate cancer xenografts.

scholarly journals Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch

Oncogene ◽  
2013 ◽  
Vol 33 (45) ◽  
pp. 5251-5261 ◽  
Author(s):  
J B Tennakoon ◽  
Y Shi ◽  
J J Han ◽  
E Tsouko ◽  
M A White ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Growth ◽  
Metabolic Switch

Sigmoidoscopic findings following radiation for prostate cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A284-A284
Author(s):  
T BOLIN ◽  
A KNEEBONE ◽  
T LARSSON
Keyword(s):  
Prostate Cancer

1625: Neuroligin 4 ISOFORM Y: A Novel Marker for Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 538-539
Author(s):  
Joseph F. Pazona ◽  
C. Shad Thaxton ◽  
Neema Navai ◽  
Brian T. Helfand ◽  
Lee C. Zhao ◽  
...  
Keyword(s):  
Prostate Cancer

232: Natural History of Treated Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 77-78
Author(s):  
Christopher R. Porter ◽  
Jochen Walz ◽  
Andrea Gallina ◽  
Claudio Jeldres ◽  
Koichi Kodama ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Natural History ◽  
Biochemical Recurrence ◽  
History Of
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