Illuminating the core of adaptive immunity—how the regulatory genome controls Rag chromatin dynamics

2020 ◽  
Vol 5 (51) ◽  
pp. eabd6427
Author(s):  
Xun Wang ◽  
Ellen V. Rothenberg
Keyword(s):  
Adaptive Immunity ◽  
Large Scale ◽  
Chromatin Dynamics ◽  
Related Research ◽  
The Core ◽  
Link Type ◽  
Research Article ◽  
Super Enhancer ◽  
Regulatory Genome ◽  
Topological Changes

E2A specifies adaptive immunity by instructing large-scale topological changes for Rag gene super-enhancer formation (see the related Research Article by Miyazaki et al.).

P2X7R: The Achilles heel of follicular helper memory T cells

2020 ◽  
Vol 5 (45) ◽  
pp. eaba8097
Author(s):  
Jeffrey C. Nolz
Keyword(s):  
T Cells ◽  
Cell Death ◽  
Memory T Cells ◽  
Related Research ◽  
Link Type ◽  
Follicular Helper ◽  
Research Article

Protecting TFH memory CD4+ T cells from NAD-induced cell death reveals both their longevity and plasticity (see related Research Article by Künzli et al.).

Cutting down the hematopoietic tree: E-cadherin reveals a landscape of differentiating basophils and mast cells

2021 ◽  
Vol 6 (56) ◽  
pp. eabf7901
Author(s):  
Joakim S. Dahlin
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Related Research ◽  
Cell Lineages ◽  
Link Type ◽  
Research Article ◽  
E Cadherin

GATA-2–mediated E-cadherin expression marks early progenitors primed to the basophil and mast cell lineages in mouse hematopoiesis (see the related Research Article by Wanet et al.).

Tregs in fibrosis: To know your enemy, you must become your enemy

2019 ◽  
Vol 4 (39) ◽  
pp. eaay1160 ◽  
Author(s):  
Suzanne M. Bal ◽  
Ralph Stadhouders
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Cytokine Production ◽  
T Helper ◽  
Related Research ◽  
T Helper 2 ◽  
Link Type ◽  
Research Article

T helper 2–skewed regulatory T cells in the skin use GATA3 to suppress local profibrotic type 2 cytokine production. See the related Research Article by Kalekar et al.

IFN-γ: The T cell’s license to kill stem cells in the inflamed intestine

2019 ◽  
Vol 4 (42) ◽  
pp. eaaz6821
Author(s):  
Kai Kretzschmar ◽  
Hans Clevers
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Cell Death ◽  
Stem Cell ◽  
Intestinal Injury ◽  
Intestinal Stem Cell ◽  
Related Research ◽  
Link Type ◽  
Research Article ◽  
Ifn Γ

IFN-γ produced by T cells directly induces intestinal stem cell death upon inflammation-induced intestinal injury (see the related Research Article byTakashimaet al.).

scholarly journals Good things come in threes

2018 ◽  
Vol 3 (30) ◽  
pp. eaav5545 ◽  
Author(s):  
Simon Yona ◽  
Alexander Mildner
Keyword(s):  
Dendritic Cells ◽  
Human Fibroblasts ◽  
Ectopic Expression ◽  
Related Research ◽  
Link Type ◽  
Research Article

Ectopic expression of PU.1, IRF8, and BATF3 reprograms mouse and human fibroblasts into dendritic cells. See related Research Article by Rosa et al.

A perfect storm: Genetics and anticommensal antibodies shore up type 1 diabetes

2019 ◽  
Vol 4 (32) ◽  
pp. eaaw3345
Author(s):  
Jacob M. Luber ◽  
Aleksandar D. Kostic
Keyword(s):  
Type 1 Diabetes ◽  
Antibody Responses ◽  
Related Research ◽  
Link Type ◽  
Research Article ◽  
Diabetes Progression ◽  
Hla Haplotypes ◽  
Perfect Storm

HLA haplotypes in conjunction with serum anticommensal antibody responses are predictive of type 1 diabetes progression. See related Research Article by Paun et al.

A singular role for interleukin-9 in the development of asthma

2020 ◽  
Vol 5 (48) ◽  
pp. eabc4021
Author(s):  
Jonathan M. Coquet
Keyword(s):  
T Helper Cells ◽  
T Helper ◽  
Related Research ◽  
Link Type ◽  
Helper Cells ◽  
Research Article ◽  
Interleukin 9

Interleukin-9 expression by T helper cells marks allergic individuals who develop asthma (see the related Research Article by Seumois et al.).

scholarly journals Lighting a fire on the reef

2020 ◽  
Vol 5 (54) ◽  
pp. eabf0905
Author(s):  
Zhibin Zhang ◽  
Judy Lieberman
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Caspase 3 ◽  
Bacterial Pathogen ◽  
Related Research ◽  
Link Type ◽  
Research Article

Coral gasdermin E is cleaved by activated caspase-3 to induce pyroptosis, a form of inflammatory programmed cell death, in response to a bacterial pathogen (see the related Research Article by Jiang et al.).

Germinal center TFH cells: T(w)o be or not t(w)o be, IL-6 is the answer

2019 ◽  
Vol 4 (39) ◽  
pp. eaay7668 ◽  
Author(s):  
Pengcheng Zhou ◽  
Kaili Liang ◽  
Di Yu
Keyword(s):  
Germinal Center ◽  
Related Research ◽  
Tfh Cells ◽  
Link Type ◽  
Research Article

IL-6 inhibits the expression of IL-2Rβ (CD122) in germinal center TFH cells to maintain IL-2 hyporesponsiveness (see the related Research Article by Papillion et al.).

A natural killer’s hike through epigenetic landscapes

2021 ◽  
Vol 6 (57) ◽  
pp. eabf8019
Author(s):  
Timo Rückert ◽  
Chiara Romagnani
Keyword(s):  
Transcription Factor ◽  
Nk Cells ◽  
Related Research ◽  
Link Type ◽  
Research Article

The transcription factor BCL11B guides NK cells along their differentiation trajectory (see the related Research Article by Holmes et al.).

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