A natural killer’s hike through epigenetic landscapes

2021 ◽  
Vol 6 (57) ◽  
pp. eabf8019
Author(s):  
Timo Rückert ◽  
Chiara Romagnani
Keyword(s):  
Transcription Factor ◽  
Nk Cells ◽  
Related Research ◽  
Link Type ◽  
Research Article

The transcription factor BCL11B guides NK cells along their differentiation trajectory (see the related Research Article by Holmes et al.).

scholarly journals Placentation and antitumor immunity regulated by a scaffolding protein in NK cells

2019 ◽  
Vol 4 (38) ◽  
pp. eaax9589
Author(s):  
Francesco Colucci
Keyword(s):  
Natural Killer Cells ◽  
Nk Cells ◽  
Natural Killer ◽  
Tumor Cells ◽  
Antitumor Immunity ◽  
Adaptor Protein ◽  
Scaffolding Protein ◽  
Trophoblast Invasion ◽  
Related Research ◽  
Research Article

Natural killer cells use the Gab3 adaptor protein to limit trophoblast invasion during pregnancy and to reject tumor cells. See the related Research Article by Sliz et al.

Illuminating the core of adaptive immunity—how the regulatory genome controls Rag chromatin dynamics

2020 ◽  
Vol 5 (51) ◽  
pp. eabd6427
Author(s):  
Xun Wang ◽  
Ellen V. Rothenberg
Keyword(s):  
Adaptive Immunity ◽  
Large Scale ◽  
Chromatin Dynamics ◽  
Related Research ◽  
The Core ◽  
Link Type ◽  
Research Article ◽  
Super Enhancer ◽  
Regulatory Genome ◽  
Topological Changes

E2A specifies adaptive immunity by instructing large-scale topological changes for Rag gene super-enhancer formation (see the related Research Article by Miyazaki et al.).

P2X7R: The Achilles heel of follicular helper memory T cells

2020 ◽  
Vol 5 (45) ◽  
pp. eaba8097
Author(s):  
Jeffrey C. Nolz
Keyword(s):  
T Cells ◽  
Cell Death ◽  
Memory T Cells ◽  
Related Research ◽  
Link Type ◽  
Follicular Helper ◽  
Research Article

Protecting TFH memory CD4+ T cells from NAD-induced cell death reveals both their longevity and plasticity (see related Research Article by Künzli et al.).

Cutting down the hematopoietic tree: E-cadherin reveals a landscape of differentiating basophils and mast cells

2021 ◽  
Vol 6 (56) ◽  
pp. eabf7901
Author(s):  
Joakim S. Dahlin
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Related Research ◽  
Cell Lineages ◽  
Link Type ◽  
Research Article ◽  
E Cadherin

GATA-2–mediated E-cadherin expression marks early progenitors primed to the basophil and mast cell lineages in mouse hematopoiesis (see the related Research Article by Wanet et al.).

Tregs in fibrosis: To know your enemy, you must become your enemy

2019 ◽  
Vol 4 (39) ◽  
pp. eaay1160 ◽  
Author(s):  
Suzanne M. Bal ◽  
Ralph Stadhouders
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Cytokine Production ◽  
T Helper ◽  
Related Research ◽  
T Helper 2 ◽  
Link Type ◽  
Research Article

T helper 2–skewed regulatory T cells in the skin use GATA3 to suppress local profibrotic type 2 cytokine production. See the related Research Article by Kalekar et al.

IFN-γ: The T cell’s license to kill stem cells in the inflamed intestine

2019 ◽  
Vol 4 (42) ◽  
pp. eaaz6821
Author(s):  
Kai Kretzschmar ◽  
Hans Clevers
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Cell Death ◽  
Stem Cell ◽  
Intestinal Injury ◽  
Intestinal Stem Cell ◽  
Related Research ◽  
Link Type ◽  
Research Article ◽  
Ifn Γ

IFN-γ produced by T cells directly induces intestinal stem cell death upon inflammation-induced intestinal injury (see the related Research Article byTakashimaet al.).

scholarly journals Good things come in threes

2018 ◽  
Vol 3 (30) ◽  
pp. eaav5545 ◽  
Author(s):  
Simon Yona ◽  
Alexander Mildner
Keyword(s):  
Dendritic Cells ◽  
Human Fibroblasts ◽  
Ectopic Expression ◽  
Related Research ◽  
Link Type ◽  
Research Article

Ectopic expression of PU.1, IRF8, and BATF3 reprograms mouse and human fibroblasts into dendritic cells. See related Research Article by Rosa et al.

A perfect storm: Genetics and anticommensal antibodies shore up type 1 diabetes

2019 ◽  
Vol 4 (32) ◽  
pp. eaaw3345
Author(s):  
Jacob M. Luber ◽  
Aleksandar D. Kostic
Keyword(s):  
Type 1 Diabetes ◽  
Antibody Responses ◽  
Related Research ◽  
Link Type ◽  
Research Article ◽  
Diabetes Progression ◽  
Hla Haplotypes ◽  
Perfect Storm

HLA haplotypes in conjunction with serum anticommensal antibody responses are predictive of type 1 diabetes progression. See related Research Article by Paun et al.

A singular role for interleukin-9 in the development of asthma

2020 ◽  
Vol 5 (48) ◽  
pp. eabc4021
Author(s):  
Jonathan M. Coquet
Keyword(s):  
T Helper Cells ◽  
T Helper ◽  
Related Research ◽  
Link Type ◽  
Helper Cells ◽  
Research Article ◽  
Interleukin 9

Interleukin-9 expression by T helper cells marks allergic individuals who develop asthma (see the related Research Article by Seumois et al.).

scholarly journals Lighting a fire on the reef

2020 ◽  
Vol 5 (54) ◽  
pp. eabf0905
Author(s):  
Zhibin Zhang ◽  
Judy Lieberman
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Caspase 3 ◽  
Bacterial Pathogen ◽  
Related Research ◽  
Link Type ◽  
Research Article

Coral gasdermin E is cleaved by activated caspase-3 to induce pyroptosis, a form of inflammatory programmed cell death, in response to a bacterial pathogen (see the related Research Article by Jiang et al.).

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